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> Protein (NX_P54257)
Protein (NX_P54257)
Protein
Gene SymbolHAP1 to neXtProt (NX_P54257)
DescriptionHuntingtin-associated protein 1
Chromosome17
Location17q21.2 (39873994 ~ 39890896) to Ensembl
Sequene Features : Isoforms 4, Variants 102, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of nonmotile primary cilium assembly
.regulation of organelle transport along microtubule
.negative regulation of beta-amyloid formation
  + 19 more...
.brain-derived neurotrophic factor binding
.ion channel binding
.axon
.cell junction
.inclusion body
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 102 1
2014-09-19protein level
4 80 1
2014-05-27protein level
4 80 1
2014-02-25protein level
4 80 1
2013-12-09protein level
4 62 1
2013-11-01protein level
4 58 1
2013-09-12protein level
4 58 1
2013-08-17protein level
4 58 1
2013-07-15protein level
4 50 1
2013-06-11protein level
4 50 1
2013-02-12protein level
4 41 0
2012-12-20protein level
4 40 0
2012-10-30protein level
4 44 0
2012-10-07protein level
4 44 0
2012-08-24protein level
4 40 0
2012-07-28protein level
4 40 0
2012-06-08protein level
4 44 0
2012-05-07protein level
4 42 0
2012-04-10protein level
4 42 0
2012-01-13protein level
4 23 0
2011-12-20protein level
4 23 0
2011-11-11protein level
4 23 0
2011-08-23protein level
4 23 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P54257-1
3 24 0 75458.7215
NX_P54257-2
1 24 0 69595.8859
NX_P54257-3
0 24 0 66663.4453
NX_P54257-4
1 23 0 67538.9004
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-9392340,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
2 EBI-712814,EBI-946046 ATXN3  
  .cellular response to misfolded protein
.protein K48-linked deubiquitination
.protein K63-linked deubiquitination
  + 14 more...
.Lys48-specific deubiquitinase activity
.Lys63-specific deubiquitinase activity
.ATPase binding
  + 4 more...
.nuclear inclusion body
.mitochondrial membrane
.nuclear matrix
  + 5 more...
3 EBI-712814,EBI-1049056 AHI1  
  .otic vesicle development
.left/right axis specification
.Kupffer's vesicle development
  + 22 more...
.identical protein binding .primary cilium
.ciliary basal body
.TCTN-B9D complex
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain109
embryonic tissue4
esophagus148
eye4
heart11
kidney4
liver4
lung2
mammary gland6
mouth120
muscle9
pancreas9
placenta7
spleen18
testis20
thymus25
trachea38
uterus73
Health State
TissuesTPM*
normal34
esophageal tumor173
germ cell tumor3
glioma46
head and neck tumor59
kidney tumor14
liver tumor10
non-neoplasia20
pancreatic tumor19
primitive neuroectodermal tumor of the CNS55
uterine tumor11
Developmental Stage
TissuesTPM*
adult6
fetus5
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
cerebral cortex5
duodenum2.1
gallbladder1.1
placenta1.4
spleen1.6
stomach9.8
testis1.6
thyroid gland3.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600947, gene) Huntingtin-associated protein 1; HAP1OMIM


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