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> Protein (NX_P54578)
Protein (NX_P54578)
Protein
Gene SymbolUSP14 to neXtProt (NX_P54578)
DescriptionUbiquitin carboxyl-terminal hydrolase 14
Chromosome18
Location18p11.32 (158383 ~ 214629) to Ensembl
Sequene Features : Isoforms 3, Variants 47, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of ER-associated ubiquitin-dependent protein catabolic process
.regulation of proteasomal protein catabolic process
.regulation of chemotaxis
  + 4 more...
.proteasome binding
.tRNA guanylyltransferase activity
.endopeptidase inhibitor activity
  + 2 more...
.extracellular exosome
.synapse
.cytoplasmic membrane-bounded vesicle
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 47 15
2014-09-19protein level
2 42 15
2014-05-27protein level
2 42 15
2014-02-25protein level
2 42 15
2013-12-09protein level
2 35 15
2013-11-01protein level
2 31 11
2013-09-12protein level
2 31 13
2013-08-17protein level
2 31 13
2013-07-15protein level
1 17 7
2013-06-11protein level
1 17 7
2013-02-12protein level
1 9 7
2012-12-20protein level
1 9 7
2012-10-30protein level
1 11 7
2012-10-07protein level
1 11 7
2012-08-24protein level
1 9 7
2012-07-28protein level
1 9 7
2012-06-08protein level
1 9 7
2012-05-07protein level
1 6 7
2012-04-10protein level
1 6 7
2012-01-13protein level
1 4 7
2011-12-20protein level
1 4 7
2011-11-11protein level
1 4 6
2011-08-23protein level
1 4 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P54578-1
1 22 0 56032.8685
NX_P54578-2
1 21 0 52352.1813
NX_P54578-3
1 21 0 54734.2466
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1048016,EBI-352922 PPP3CA  
  .positive regulation of cardiac muscle hypertrophy in response to stress
.cellular response to glucose stimulus
.regulation of excitatory postsynaptic membrane potential
  + 20 more...
.protein dimerization activity
.calmodulin-dependent protein phosphatase activity
.enzyme binding
  + 4 more...
.sarcolemma
.Z disc
.calcineurin complex
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland182
ascites125
bladder334
blood122
bone111
bone marrow102
brain135
cervix20
connective tissue174
embryonic tissue89
esophagus198
eye43
heart11
intestine47
kidney128
liver204
lung2
lymph45
lymph node122
mammary gland85
mouth181
muscle103
ovary88
pancreas4
parathyroid97
pituitary gland60
placenta3
prostate5
salivary gland49
skin156
spleen93
stomach20
testis4
thymus62
trachea135
umbilical cord145
uterus107
vascular96
Health State
TissuesTPM*
normal98
adrenal tumor316
bladder carcinoma341
breast (mammary gland) tumor107
cervical tumor28
chondrosarcoma72
colorectal tumor35
esophageal tumor231
gastrointestinal tumor42
germ cell tumor7
glioma102
head and neck tumor82
kidney tumor87
leukemia105
liver tumor385
lung tumor87
lymphoma55
non-neoplasia10
ovarian tumor118
pancreatic tumor9
primitive neuroectodermal tumor of the CNS133
prostate cancer9
retinoblastoma107
skin tumor119
soft tissue/muscle tissue tumor151
uterine tumor99
Developmental Stage
TissuesTPM*
adult3
embryoid body128
blastocyst16
neonate547
fetus3
infant255
juvenile215
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue27.5
adrenal gland24.1
appendix28.4
bone marrow33.7
cerebral cortex32.9
colon22.4
duodenum16.6
esophagus28.9
gallbladder22.8
heart muscle21.7
kidney22.2
liver15.3
lung18.4
lymph node28.9
ovary17.6
pancreas8.9
placenta28.4
prostate34.4
salivary gland10.7
skin17.2
small intestine15.9
spleen16.8
stomach19.6
testis23.6
thyroid gland30.4
urinary bladder26
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607274, gene) Ubiquitin-specific protease 14; USP14OMIM


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