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> Protein (NX_P54619)
Protein (NX_P54619)
Protein
Gene SymbolPRKAG1 to neXtProt (NX_P54619)
Description5'-AMP-activated protein kinase subunit gamma-1
Chromosome12
Location12q13.12 (49396057 ~ 49412980) to Ensembl
Sequene Features : Isoforms 3, Variants 39, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane organization
.protein heterooligomerization
.positive regulation of protein kinase activity
  + 12 more...
.ADP binding
.protein kinase binding
.AMP binding
  + 5 more...
.extracellular exosome
.AMP-activated protein kinase complex
.membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 39 6
2014-09-19protein level
3 32 6
2014-05-27protein level
3 32 6
2014-02-25protein level
3 32 6
2013-12-09protein level
3 27 6
2013-11-01protein level
3 25 3
2013-09-12protein level
3 25 3
2013-08-17protein level
3 25 3
2013-07-15protein level
1 14 3
2013-06-11protein level
1 14 3
2013-02-12protein level
1 5 5
2012-12-20protein level
1 5 5
2012-10-30protein level
1 5 5
2012-10-07protein level
1 5 5
2012-08-24protein level
1 3 5
2012-07-28protein level
1 3 5
2012-06-08protein level
1 6 5
2012-05-07protein level
1 6 5
2012-04-10protein level
1 6 5
2012-01-13protein level
1 5 5
2011-12-20protein level
1 5 5
2011-11-11protein level
1 5 5
2011-08-23protein level
1 2 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P54619-1
0 17 3 37555.6635
NX_P54619-2
0 16 3 34062.1623
NX_P54619-3
1 17 2 38508.2134
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1181439,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
2 EBI-1181439,EBI-740135 CBS  
  .hydrogen sulfide biosynthetic process
.oxidation-reduction process
.homocysteine metabolic process
  + 12 more...
.S-adenosyl-L-methionine binding
.modified amino acid binding
.nitric oxide binding
  + 11 more...
.intracellular membrane-bounded organelle
.cytosol
.nucleolus
.nucleus
3 EBI-1181439,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
4 EBI-1181439,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
5 EBI-1181439,EBI-751001 KEAP1  
  .cellular response to interleukin-4
.regulation of epidermal cell differentiation
.negative regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.transcription factor binding .Cul3-RING ubiquitin ligase complex
.midbody
.cytosol
  + 4 more...
6 EBI-1181439,EBI-946029 C1orf94  
  .N/A .N/A .N/A
7 EBI-1181439,EBI-10180409 TEKT1  
  .N/A .N/A .cilium
.microtubule
.cytoplasm
.nucleus
8 EBI-1181439,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
9 EBI-1181439,EBI-719769 PRKAB1  
  .membrane organization
.protein heterooligomerization
.regulation of protein kinase activity
  + 10 more...
.AMP-activated protein kinase activity
.protein kinase activity
.AMP-activated protein kinase complex
.cytosol
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland151
ascites150
blood81
bone27
bone marrow20
brain61
cervix268
connective tissue26
embryonic tissue89
eye62
heart134
intestine68
kidney42
liver53
lung47
lymph90
lymph node66
mammary gland112
mouth60
muscle94
ovary49
pancreas56
parathyroid242
pharynx122
placenta95
prostate63
skin104
spleen18
stomach261
testis130
thymus87
thyroid64
uterus56
vascular19
Health State
TissuesTPM*
normal64
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor161
cervical tumor318
chondrosarcoma72
colorectal tumor71
gastrointestinal tumor210
germ cell tumor79
glioma74
head and neck tumor52
kidney tumor43
leukemia31
liver tumor62
lung tumor68
lymphoma69
non-neoplasia51
ovarian tumor52
pancreatic tumor47
primitive neuroectodermal tumor of the CNS110
prostate cancer67
skin tumor143
soft tissue/muscle tissue tumor87
uterine tumor77
Developmental Stage
TissuesTPM*
adult83
embryoid body28
blastocyst97
neonate32
fetus48
infant127
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue35.5
adrenal gland50.5
appendix35.5
bone marrow25.2
cerebral cortex30.6
colon40.8
duodenum33.5
esophagus47.4
gallbladder35.7
heart muscle67.4
kidney39.8
liver23.6
lung30.9
lymph node39.3
ovary27.5
pancreas19.6
placenta32.2
prostate38.8
salivary gland27.6
skin36.1
small intestine29.6
spleen29
stomach31.9
testis34.7
thyroid gland42.4
urinary bladder46
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*602742, gene) Protein kinase, amp-activated, noncatalytic, gamma-1; PRKAG1OMIM


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