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> Protein (NX_P54646)
Protein (NX_P54646)
Protein
Gene SymbolPRKAA2 to neXtProt (NX_P54646)
Description5'-AMP-activated protein kinase catalytic subunit alpha-2
Chromosome1
Location1p32.2 (57110995 ~ 57181008) to Ensembl
Sequene Features : Isoforms 1, Variants 106, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 106 4
2014-09-19protein level
1 67 4
2014-05-27protein level
1 67 4
2014-02-25protein level
1 67 4
2013-12-09protein level
1 59 4
2013-11-01protein level
1 55 4
2013-09-12protein level
1 55 6
2013-08-17protein level
1 55 6
2013-07-15protein level
1 33 6
2013-06-11protein level
1 33 6
2013-02-12protein level
1 14 8
2012-12-20protein level
1 14 8
2012-10-30protein level
1 19 8
2012-10-07protein level
1 19 8
2012-08-24protein level
1 19 8
2012-07-28protein level
1 19 8
2012-06-08protein level
1 24 8
2012-05-07protein level
1 13 8
2012-04-10protein level
1 13 8
2012-01-13protein level
1 12 8
2011-12-20protein level
1 12 8
2011-11-11protein level
1 12 8
2011-08-23protein level
1 11 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P54646-1
21 0 3 62279.3944
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1383852,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
2 EBI-1383852,EBI-308084 GLI1  
  .negative regulation of canonical Wnt signaling pathway
.notochord regression
.digestive tract morphogenesis
  + 17 more...
.metal ion binding
.transcription regulatory region DNA binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
  + 2 more...
.ciliary base
.ciliary tip
.primary cilium
  + 5 more...
3 EBI-1383852,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
4 EBI-1383852,EBI-1181439 PRKAG1  
  .membrane organization
.protein heterooligomerization
.positive regulation of protein kinase activity
  + 12 more...
.ADP binding
.protein kinase binding
.AMP binding
  + 5 more...
.extracellular exosome
.AMP-activated protein kinase complex
.membrane
  + 2 more...
5 EBI-1383852,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
6 EBI-1383852,EBI-745226 AIMP2  
  .Type II pneumocyte differentiation
.positive regulation of protein ubiquitination
.gene expression
  + 3 more...
.N/A .membrane
.cytosol
.nucleus
7 EBI-1383852,EBI-10203843 NONO  
  .negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.negative regulation of transcription, DNA-templated
.regulation of circadian rhythm
  + 6 more...
.poly(A) RNA binding
.identical protein binding
.core promoter binding
.nucleotide binding
.paraspeckles
.nuclear speck
.nuclear matrix
  + 4 more...
8 EBI-1383852,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
9 EBI-1383852,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
10 EBI-1383852,EBI-10213781 KIF24  
  .cilium assembly
.metabolic process
.microtubule depolymerization
  + 2 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.protein complex
.microtubule
.kinesin complex
  + 2 more...
11 EBI-1383852,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
12 EBI-1383852,EBI-9027502 KCTD1  
  .protein homooligomerization
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.transcription factor binding
.transcription corepressor activity
.nucleus
13 EBI-1383852,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
14 EBI-1383852,EBI-10178410 NUTM1  
  .N/A .N/A .cytoplasm
.nucleus
15 EBI-1383852,EBI-746118 RFX6  
  .pancreatic epsilon cell differentiation
.regulation of insulin secretion
.positive regulation of transcription from RNA polymerase II promoter
  + 7 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  + 2 more...
.nucleus
16 EBI-1383852,EBI-10172004 HOMEZ  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
17 EBI-1383852,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
18 EBI-1383852,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
19 EBI-1383852,EBI-10213894 ZNF397  
  .transcription, DNA-templated .metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleus
20 EBI-1383852,EBI-743771 APPBP2  
  .intracellular transport
.metabolic process
.intracellular protein transport
.microtubule motor activity .cytoplasmic vesicle membrane
.microtubule associated complex
.microtubule
  + 2 more...
21 EBI-1383852,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
22 EBI-1383852,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
23 EBI-1383852,EBI-2686809 L3MBTL3  
  .erythrocyte maturation
.granulocyte differentiation
.macrophage differentiation
  + 3 more...
.N/A .nucleus
24 EBI-1383852,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
25 EBI-1383852,EBI-745269 CCNB1IP1  
  .chiasma assembly
.protein ubiquitination
.spermatid development
  + 2 more...
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
.nuclear lumen
.synaptonemal complex
26 EBI-1383852,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
27 EBI-1383852,EBI-739485 TSC22D4  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.sequence-specific DNA binding transcription factor activity .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain15
ear62
embryonic tissue14
eye86
heart100
intestine4
kidney85
liver4
lung20
muscle103
ovary19
pancreas18
parathyroid48
prostate10
testis6
thymus25
uterus21
Health State
TissuesTPM*
normal27
germ cell tumor15
kidney tumor29
lung tumor38
ovarian tumor26
pancreatic tumor9
prostate cancer19
retinoblastoma21
uterine tumor22
Developmental Stage
TissuesTPM*
adult20
blastocyst16
fetus43
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.1
adrenal gland1.5
cerebral cortex3.2
colon1.4
esophagus5.2
gallbladder2.2
heart muscle32.3
kidney12.8
lung1.2
ovary1.5
prostate4.6
salivary gland3.2
spleen1.1
stomach1.3
testis1.3
thyroid gland3.4
urinary bladder1.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600497, gene) Protein kinase, amp-activated, catalytic, alpha-2; PRKAA2OMIM


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