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> Protein (NX_P54725)
Protein (NX_P54725)
Protein
Gene SymbolRAD23A to neXtProt (NX_P54725)
DescriptionUV excision repair protein RAD23 homolog A
Chromosome19
Location19p13.2 (13056669 ~ 13064456) to Ensembl
Sequene Features : Isoforms 3, Variants 40, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of viral genome replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin-specific protease binding
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.cytoplasm
.nucleoplasm
.proteasome complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 40 13
2014-09-19protein level
3 30 13
2014-05-27protein level
3 30 15
2014-02-25protein level
2 30 15
2013-12-09protein level
2 25 16
2013-11-01protein level
2 24 13
2013-09-12protein level
2 24 13
2013-08-17protein level
2 24 12
2013-07-15protein level
1 16 8
2013-06-11protein level
1 16 8
2013-02-12protein level
1 12 9
2012-12-20protein level
1 12 9
2012-10-30protein level
1 11 9
2012-10-07protein level
1 11 9
2012-08-24protein level
1 9 9
2012-07-28protein level
1 9 9
2012-06-08protein level
1 23 9
2012-05-07protein level
1 21 9
2012-04-10protein level
1 21 9
2012-01-13protein level
1 19 9
2011-12-20protein level
1 19 9
2011-11-11protein level
1 19 9
2011-08-23protein level
1 19 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P54725-1
0 14 2 39584.5369
NX_P54725-2
1 12 2 33412.5747
NX_P54725-3
1 13 2 39513.5
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-746453,EBI-523498 TRAF5  
  .positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 4 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
  + 2 more...
.CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytosol
  + 2 more...
2 EBI-746453,EBI-359318 PSMD4  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 21 more...
.poly(A) RNA binding
.identical protein binding
.proteasome accessory complex
.proteasome regulatory particle, base subcomplex
.cytosol
  + 3 more...
3 EBI-746453,EBI-352162 EEF1A1  
  .cellular response to epidermal growth factor stimulus
.cellular protein metabolic process
.gene expression
  + 4 more...
.poly(A) RNA binding
.protein kinase binding
.GTP binding
  + 3 more...
.extracellular exosome
.ruffle membrane
.cortical actin cytoskeleton
  + 7 more...
4 EBI-746453,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
5 EBI-746453,EBI-307104 SQSTM1  
  .activation of mitophagy in response to mitochondrial depolarization
.apoptotic signaling pathway
.protein heterooligomerization
  + 20 more...
.ubiquitin binding
.identical protein binding
.SH2 domain binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.PML body
  + 11 more...
6 EBI-746453,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
7 EBI-746453,EBI-2838246 ANKRD40  
  .N/A .N/A .N/A
8 EBI-746453,EBI-5658292 ZBTB44  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
9 EBI-746453,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
10 EBI-746453,EBI-6165879 NGLY1  
  .glycoprotein catabolic process .metal ion binding
.peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
.cytoplasm
11 EBI-746453,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
12 EBI-746453,EBI-724928 FAM188A  
  .apoptotic process .N/A .nuclear membrane
.nucleoplasm
13 EBI-746453,EBI-947187 UBQLN2  
  .regulation of autophagic vacuole assembly
.negative regulation of G-protein coupled receptor internalization
.positive regulation of ER-associated ubiquitin-dependent protein catabolic process
  + 2 more...
.N/A .plasma membrane
.cytoplasm
.nucleus
14 EBI-746453,EBI-2513462 USP25  
  .protein K48-linked deubiquitination
.protein K63-linked deubiquitination
.regulation of proteasomal protein catabolic process
  + 3 more...
.SUMO binding
.peptidase activity
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland121
ascites301
bladder167
blood220
bone237
bone marrow102
brain91
cervix185
connective tissue80
embryonic tissue42
esophagus148
eye196
heart167
intestine146
kidney56
liver87
lung173
lymph135
lymph node222
mammary gland46
muscle235
ovary118
pancreas98
parathyroid194
pharynx24
pituitary gland121
placenta109
prostate142
salivary gland296
skin185
spleen74
stomach94
testis107
thymus25
thyroid64
tonsil58
umbilical cord145
uterus112
vascular38
Health State
TissuesTPM*
normal121
adrenal tumor158
bladder carcinoma227
breast (mammary gland) tumor75
cervical tumor202
chondrosarcoma229
colorectal tumor106
esophageal tumor173
gastrointestinal tumor210
germ cell tumor60
glioma205
head and neck tumor67
kidney tumor87
leukemia190
liver tumor62
lung tumor175
lymphoma235
non-neoplasia51
ovarian tumor105
pancreatic tumor76
primitive neuroectodermal tumor of the CNS196
prostate cancer144
retinoblastoma236
skin tumor167
soft tissue/muscle tissue tumor175
uterine tumor155
Developmental Stage
TissuesTPM*
adult136
embryoid body71
neonate64
fetus161
juvenile215
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue75.4
adrenal gland55.5
appendix60.2
bone marrow85.2
cerebral cortex54.7
colon52.4
duodenum51.7
esophagus69
gallbladder48.7
heart muscle103.7
kidney46.9
liver37
lung62.6
lymph node64.6
ovary57.7
pancreas42.7
placenta65.1
prostate58.4
salivary gland57.6
skin69.1
small intestine48.3
spleen60.7
stomach49.7
testis67.8
thyroid gland69.3
urinary bladder59.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixLow
bone marrowMedium
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineHigh
colonMedium
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasMedium
parathyroid glandLow
placentaHigh
prostateMedium
rectumMedium
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600061, gene) Rad23, yeast, homolog of, a; RAD23AOMIM


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