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> Protein (NX_P54727)
Protein (NX_P54727)
Protein
Gene SymbolRAD23B to neXtProt (NX_P54727)
DescriptionUV excision repair protein RAD23 homolog B
Chromosome9
Location9q31.2 (110045418 ~ 110094475) to Ensembl
Sequene Features : Isoforms 2, Variants 38, PTMs 18 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
.spermatogenesis
  + 4 more...
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.XPC complex
.cytoplasm
.nucleoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 38 18
2014-09-19protein level
2 28 18
2014-05-27protein level
2 28 20
2014-02-25protein level
2 28 20
2013-12-09protein level
2 22 20
2013-11-01protein level
2 22 15
2013-09-12protein level
2 22 15
2013-08-17protein level
2 22 15
2013-07-15protein level
2 16 7
2013-06-11protein level
2 16 7
2013-02-12protein level
1 5 7
2012-12-20protein level
1 5 7
2012-10-30protein level
1 7 7
2012-10-07protein level
1 7 7
2012-08-24protein level
1 6 7
2012-07-28protein level
1 6 7
2012-06-08protein level
1 8 7
2012-05-07protein level
1 5 7
2012-04-10protein level
1 5 7
2012-01-13protein level
1 8 7
2011-12-20protein level
1 8 7
2011-11-11protein level
1 8 6
2011-08-23protein level
1 8 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P54727-1
3 12 2 43144.4971
NX_P54727-2
0 12 0 34983.1249
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-954531,EBI-353844 VIM  
  .lens fiber cell development
.SMAD protein signal transduction
.Bergmann glial cell differentiation
  + 10 more...
.keratin filament binding
.scaffold protein binding
.identical protein binding
  + 5 more...
.extracellular exosome
.intermediate filament cytoskeleton
.neuron projection
  + 8 more...
2 EBI-954531,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
3 EBI-954531,EBI-1183307 ERCC3  
  .regulation of mitotic cell cycle phase transition
.positive regulation of viral transcription
.positive regulation of transcription from RNA polymerase II promoter
  + 27 more...
.protein N-terminus binding
.3'-5' DNA helicase activity
.peptide binding
  + 10 more...
.holo TFIIH complex
.nucleoplasm
.nucleus
.core TFIIH complex
4 EBI-954531,EBI-741277 USP5  
  .protein K48-linked deubiquitination
.positive regulation of proteasomal ubiquitin-dependent protein catabolic process
.ubiquitin-dependent protein catabolic process
.zinc ion binding
.omega peptidase activity
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.lysosome
5 EBI-954531,EBI-946046 ATXN3  
  .cellular response to misfolded protein
.protein K48-linked deubiquitination
.protein K63-linked deubiquitination
  + 14 more...
.Lys48-specific deubiquitinase activity
.Lys63-specific deubiquitinase activity
.ATPase binding
  + 4 more...
.nuclear inclusion body
.mitochondrial membrane
.nuclear matrix
  + 5 more...
6 EBI-954531,EBI-359318 PSMD4  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 21 more...
.poly(A) RNA binding
.identical protein binding
.proteasome accessory complex
.proteasome regulatory particle, base subcomplex
.cytosol
  + 3 more...
7 EBI-954531,EBI-372610 XPC  
  .regulation of mitotic cell cycle phase transition
.UV-damage excision repair
.cellular protein metabolic process
  + 10 more...
.single-stranded DNA binding
.damaged DNA binding
.bubble DNA binding
.heteroduplex DNA loop binding
.XPC complex
.extracellular exosome
.plasma membrane
  + 5 more...
8 EBI-954531,EBI-954387 ADRM1  
  .proteasome assembly
.positive regulation of endopeptidase activity
.transcription elongation from RNA polymerase II promoter
.proteasome binding
.endopeptidase activator activity
.protease binding
.membrane
.integral component of plasma membrane
.plasma membrane
  + 3 more...
9 EBI-954531,EBI-717567 UBA3  
  .regulation of cell cycle
.protein neddylation
.innate immune response
  + 4 more...
.protein heterodimerization activity
.NEDD8 activating enzyme activity
.acid-amino acid ligase activity
.ATP binding
.cytosol
.nucleus
10 EBI-954531,EBI-6165879 NGLY1  
  .glycoprotein catabolic process .metal ion binding
.peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
.cytoplasm
11 EBI-954531,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
12 EBI-954531,EBI-1053259 PUF60  
  .RNA splicing
.apoptotic process
.mRNA processing
  + 2 more...
.poly(A) RNA binding
.identical protein binding
.DNA binding
.nucleotide binding
.ribonucleoprotein complex
.Golgi apparatus
.mitochondrion
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites25
bladder267
blood57
bone69
bone marrow143
brain64
cervix103
connective tissue127
ear124
embryonic tissue117
eye100
heart134
intestine103
kidney75
larynx85
liver102
lung367
lymph67
lymph node100
mammary gland317
mouth196
muscle141
nerve193
ovary59
pancreas42
parathyroid97
pharynx24
pituitary gland121
placenta229
prostate110
salivary gland49
skin166
stomach114
testis96
thymus62
thyroid107
trachea19
umbilical cord145
uterus107
vascular135
Health State
TissuesTPM*
normal133
adrenal tumor79
bladder carcinoma511
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma84
colorectal tumor133
gastrointestinal tumor84
germ cell tumor79
glioma37
head and neck tumor149
kidney tumor72
leukemia105
liver tumor83
lung tumor48
lymphoma110
non-neoplasia10
ovarian tumor65
pancreatic tumor19
primitive neuroectodermal tumor of the CNS94
prostate cancer134
retinoblastoma129
skin tumor111
soft tissue/muscle tissue tumor71
uterine tumor77
Developmental Stage
TissuesTPM*
adult169
embryoid body228
blastocyst65
neonate193
fetus78
infant42
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue79.2
adrenal gland61.4
appendix64.2
bone marrow58.3
cerebral cortex61.1
colon68.9
duodenum54.3
esophagus88.9
gallbladder52.5
heart muscle54.6
kidney54
liver118.5
lung48.4
lymph node55.6
ovary51.9
pancreas46.8
placenta111.4
prostate62.1
salivary gland38
skin69.2
small intestine51.3
spleen43
stomach54
testis87.2
thyroid gland65.9
urinary bladder72.1
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleMedium
liverHigh
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1High
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600062, gene) Rad23, yeast, homolog of, b; RAD23BOMIM


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2014-2019 (C) Yonsei Proteome Research Center