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> Protein (NX_P54845)
Protein (NX_P54845)
Protein
Gene SymbolNRL to neXtProt (NX_P54845)
DescriptionNeural retina-specific leucine zipper protein
Chromosome14
Location14q11.2 (24549316 ~ 24584223) to Ensembl
Sequene Features : Isoforms 2, Variants 20, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.response to stimulus
.retinal rod cell development
.positive regulation of transcription from RNA polymerase II promoter
  + 4 more...
.leucine zipper domain binding
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 20 2
2014-09-19protein level
2 15 2
2014-05-27protein level
1 15 2
2014-02-25protein level
1 15 2
2013-12-09protein level
1 10 2
2013-11-01protein level
1 9 2
2013-09-12protein level
1 9 2
2013-08-17protein level
1 9 2
2013-07-15protein level
1 8 2
2013-06-11protein level
1 8 2
2013-02-12protein level
1 6 2
2012-12-20protein level
1 6 2
2012-10-30protein level
1 5 2
2012-10-07protein level
1 5 2
2012-08-24protein level
1 5 2
2012-07-28protein level
1 4 2
2012-06-08protein level
1 4 2
2012-05-07protein level
1 4 2
2012-04-10protein level
1 4 2
2012-01-13protein level
1 6 2
2011-12-20protein level
1 6 2
2011-11-11protein level
1 6 0
2011-08-23protein level
1 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P54845-1
3 2 0 25924.0761
NX_P54845-2
0 2 0 11269.0147
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-9819090,EBI-748974 OPTN  
  .Golgi ribbon formation
.defense response to Gram-negative bacterium
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 10 more...
.K63-linked polyubiquitin binding
.identical protein binding
.polyubiquitin binding
  + 2 more...
.recycling endosome
.perinuclear region of cytoplasm
.cytoplasmic membrane-bounded vesicle
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
brain5
embryonic tissue4
eye263
liver14
stomach10
testis4
Health State
TissuesTPM*
normal17
germ cell tumor15
lymphoma27
primitive neuroectodermal tumor of the CNS31
retinoblastoma236
Developmental Stage
TissuesTPM*
adult22
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1.3
cerebral cortex1.3
heart muscle1.2
kidney2
prostate1
spleen1.5
testis1.9
thyroid gland2.3
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(+162080, gene/phenotype) Neural retina leucine zipper; NRLOMIM
2(#613750, phenotype) Retinitis pigmentosa 27; RP27OMIM


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