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> Protein (NX_P54886)
Protein (NX_P54886)
Protein
Gene SymbolALDH18A1 to neXtProt (NX_P54886)
DescriptionDelta-1-pyrroline-5-carboxylate synthase
Chromosome10
Location10q24.1 (97365696 ~ 97416463) to Ensembl
Sequene Features : Isoforms 2, Variants 72, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.L-proline biosynthetic process
.small molecule metabolic process
.cellular nitrogen compound metabolic process
  + 5 more...
.NADP binding
.poly(A) RNA binding
.ATP binding
  + 2 more...
.mitochondrial inner membrane
.mitochondrion
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 72 5
2014-09-19protein level
2 63 5
2014-05-27protein level
2 63 5
2014-02-25protein level
2 64 2
2013-12-09protein level
2 49 2
2013-11-01protein level
2 48 1
2013-09-12protein level
2 48 1
2013-08-17protein level
2 48 1
2013-07-15protein level
2 35 0
2013-06-11protein level
2 35 0
2013-02-12protein level
2 16 0
2012-12-20protein level
2 17 0
2012-10-30protein level
2 22 0
2012-10-07protein level
2 22 0
2012-08-24protein level
2 15 0
2012-07-28protein level
2 15 0
2012-06-08protein level
2 22 0
2012-05-07protein level
2 22 0
2012-04-10protein level
2 22 0
2012-01-13protein level
2 20 0
2011-12-20protein level
2 20 0
2011-11-11protein level
2 20 0
2011-08-23protein level
2 20 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P54886-1
1 40 0 87247.2892
NX_P54886-2
1 40 0 87034.1785
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1210304,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
2 EBI-1210304,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites125
bladder66
blood89
bone111
bone marrow123
brain71
cervix164
connective tissue127
ear372
embryonic tissue131
esophagus49
eye71
heart55
intestine112
kidney75
larynx127
liver58
lung77
lymph22
lymph node77
mammary gland125
mouth181
muscle56
nerve64
ovary98
pancreas121
pituitary gland121
placenta130
prostate105
salivary gland98
skin113
spleen18
stomach41
testis135
thymus125
thyroid150
trachea598
uterus86
vascular96
Health State
TissuesTPM*
normal85
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor171
cervical tumor57
chondrosarcoma120
colorectal tumor124
esophageal tumor57
gastrointestinal tumor50
germ cell tumor216
glioma65
head and neck tumor127
kidney tumor58
leukemia105
liver tumor93
lung tumor87
lymphoma27
non-neoplasia113
ovarian tumor91
pancreatic tumor85
primitive neuroectodermal tumor of the CNS70
prostate cancer125
retinoblastoma43
skin tumor119
soft tissue/muscle tissue tumor47
uterine tumor110
Developmental Stage
TissuesTPM*
adult104
embryoid body157
blastocyst146
neonate32
fetus114
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.1
adrenal gland14.2
appendix21.8
bone marrow10.2
cerebral cortex11.5
colon55.7
duodenum78.6
esophagus19.4
gallbladder28
heart muscle8.3
kidney16.8
liver10.5
lung10.6
lymph node21.7
ovary16.9
pancreas28.4
placenta25.5
prostate23.7
salivary gland85.9
skin19.2
small intestine64.5
spleen11.1
stomach35.5
testis13.7
thyroid gland40.1
urinary bladder25.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineLow
colonHigh
duodenumMedium
endometrium 2Medium
epididymisMedium
fallopian tubeLow
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyLow
lateral ventricleLow
lungLow
lymph nodeMedium
nasopharynxLow
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateLow
rectumMedium
salivary glandLow
seminal vesicleMedium
skeletal muscleMedium
skin 1Low
small intestineMedium
smooth muscleLow
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*138250, gene) Aldehyde dehydrogenase 18 family, member a1; ALDH18A1OMIM
2(#219150, phenotype) Cutis laxa, autosomal recessive, type iiia; ARCL3AOMIM


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