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> Protein (NX_P55036)
Protein (NX_P55036)
Protein
Gene SymbolPSMD4 to neXtProt (NX_P55036)
Description26S proteasome non-ATPase regulatory subunit 4
Chromosome1
Location1q21.3 (151227179 ~ 151239955) to Ensembl
Sequene Features : Isoforms 2, Variants 36, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 21 more...
.poly(A) RNA binding
.identical protein binding
.proteasome accessory complex
.proteasome regulatory particle, base subcomplex
.cytosol
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 36 12
2014-09-19protein level
2 29 12
2014-05-27protein level
2 29 16
2014-02-25protein level
2 29 16
2013-12-09protein level
2 22 16
2013-11-01protein level
2 20 15
2013-09-12protein level
2 20 16
2013-08-17protein level
2 20 16
2013-07-15protein level
2 13 9
2013-06-11protein level
2 13 9
2013-02-12protein level
2 3 10
2012-12-20protein level
2 3 10
2012-10-30protein level
2 5 10
2012-10-07protein level
2 5 8
2012-08-24protein level
2 5 8
2012-07-28protein level
2 5 8
2012-06-08protein level
2 5 8
2012-05-07protein level
2 4 8
2012-04-10protein level
2 4 8
2012-01-13protein level
2 7 8
2011-12-20protein level
2 7 8
2011-11-11protein level
2 7 7
2011-08-23protein level
2 7 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P55036-1
5 9 0 40711.0829
NX_P55036-2
1 9 0 28594.5416
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-359318,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
2 EBI-359318,EBI-746453 RAD23A  
  .positive regulation of viral genome replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin-specific protease binding
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.cytoplasm
.nucleoplasm
.proteasome complex
3 EBI-359318,EBI-954531 RAD23B  
  .proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
.spermatogenesis
  + 4 more...
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.XPC complex
.cytoplasm
.nucleoplasm
  + 2 more...
4 EBI-359318,EBI-357648 PSMD2  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 21 more...
.enzyme regulator activity .extracellular exosome
.proteasome accessory complex
.membrane
  + 4 more...
5 EBI-359318,EBI-954387 ADRM1  
  .proteasome assembly
.positive regulation of endopeptidase activity
.transcription elongation from RNA polymerase II promoter
.proteasome binding
.endopeptidase activator activity
.protease binding
.membrane
.integral component of plasma membrane
.plasma membrane
  + 3 more...
6 EBI-359318,EBI-1397509 SCHIP1  
  .N/A .identical protein binding .cytoplasm
7 EBI-359318,EBI-947187 UBQLN2  
  .regulation of autophagic vacuole assembly
.negative regulation of G-protein coupled receptor internalization
.positive regulation of ER-associated ubiquitin-dependent protein catabolic process
  + 2 more...
.N/A .plasma membrane
.cytoplasm
.nucleus
8 EBI-359318,EBI-741480 UBQLN1  
  .regulation of autophagic vacuole assembly
.positive regulation of ER-associated ubiquitin-dependent protein catabolic process
.regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 8 more...
.identical protein binding
.polyubiquitin binding
.kinase binding
.perinuclear region of cytoplasm
.protein complex
.aggresome
  + 6 more...
9 EBI-359318,EBI-1051183 UCHL5  
  .regulation of proteasomal protein catabolic process
.forebrain morphogenesis
.midbrain development
  + 10 more...
.proteasome binding
.poly(A) RNA binding
.omega peptidase activity
  + 2 more...
.Ino80 complex
.cytosol
.nucleus
.proteasome complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites376
bladder100
blood40
bone195
bone marrow82
brain53
cervix206
connective tissue53
embryonic tissue281
esophagus49
eye143
heart89
intestine202
kidney66
liver63
lung241
lymph270
lymph node77
mammary gland132
muscle103
ovary275
pancreas98
parathyroid97
placenta148
prostate89
salivary gland345
skin128
stomach114
testis39
thymus25
thyroid279
tonsil235
umbilical cord145
uterus124
vascular38
Health State
TissuesTPM*
normal69
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor182
cervical tumor289
chondrosarcoma217
colorectal tumor319
esophageal tumor57
gastrointestinal tumor236
germ cell tumor136
glioma177
head and neck tumor67
kidney tumor101
leukemia21
liver tumor124
lung tumor496
lymphoma249
non-neoplasia82
ovarian tumor341
pancreatic tumor133
primitive neuroectodermal tumor of the CNS125
prostate cancer115
retinoblastoma387
skin tumor167
soft tissue/muscle tissue tumor175
uterine tumor88
Developmental Stage
TissuesTPM*
adult138
embryoid body314
blastocyst309
neonate64
fetus50
infant127
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue48.9
adrenal gland50.7
appendix51.9
bone marrow34.5
cerebral cortex51.6
colon49.2
duodenum38.2
esophagus38
gallbladder33.5
heart muscle51.5
kidney45.5
liver46.9
lung41.3
lymph node51.6
ovary44.4
pancreas25.7
placenta58.3
prostate46.5
salivary gland35.8
skin45.6
small intestine36.8
spleen56.7
stomach40.2
testis60
thyroid gland30.2
urinary bladder38.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastLow
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisLow
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandLow
seminal vesicleLow
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601648, gene) Proteasome 26s subunit, non-atpase, 4; PSMD4OMIM


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