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> Protein (NX_P55040)
Protein (NX_P55040)
Protein
Gene SymbolGEM to neXtProt (NX_P55040)
DescriptionGTP-binding protein GEM
Chromosome8
Location8q22.1 (95261481 ~ 95274578) to Ensembl
Sequene Features : Isoforms 1, Variants 56, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 56 0
2014-09-19protein level
1 42 0
2014-05-27protein level
1 42 0
2014-02-25protein level
1 42 0
2013-12-09protein level
1 32 0
2013-11-01protein level
1 29 0
2013-09-12protein level
1 29 0
2013-08-17protein level
1 29 0
2013-07-15protein level
1 25 0
2013-06-11protein level
1 25 0
2013-02-12protein level
1 15 0
2012-12-20protein level
1 14 0
2012-10-30protein level
1 16 0
2012-10-07protein level
1 16 0
2012-08-24protein level
1 11 0
2012-07-28protein level
1 11 0
2012-06-08protein level
1 13 0
2012-05-07protein level
1 13 0
2012-04-10protein level
1 13 0
2012-01-13protein level
1 10 0
2011-12-20protein level
1 10 0
2011-11-11protein level
1 10 0
2011-08-23protein level
1 10 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P55040-1
14 0 2 33927.8888
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-744104,EBI-2371423 AHCYL1  
  .response to calcium ion
.regulation of anion transport
.S-adenosylmethionine cycle
  + 6 more...
.hydrolase activity .extracellular exosome
.cytosol
.endoplasmic reticulum
2 EBI-744104,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
3 EBI-744104,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
4 EBI-744104,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
5 EBI-744104,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
6 EBI-744104,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
7 EBI-744104,EBI-748597 CCDC67  
  .multi-ciliated epithelial cell differentiation
.de novo centriole assembly
.cell projection organization
.N/A .deuterosome
.cytoplasm
8 EBI-744104,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
9 EBI-744104,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
10 EBI-744104,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
11 EBI-744104,EBI-747225 RUNDC3A  
  .small GTPase mediated signal transduction .GTPase regulator activity
.guanylate cyclase activator activity
.plasma membrane
.cytosol
12 EBI-744104,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
13 EBI-744104,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
14 EBI-744104,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
15 EBI-744104,EBI-769401 INO80E  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA recombination
  + 2 more...
.N/A .Ino80 complex
.nucleolus
.nucleoplasm
.nucleus
16 EBI-744104,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
17 EBI-744104,EBI-720875 COG8  
  .protein transport .N/A .Golgi transport complex
.membrane
.Golgi membrane
18 EBI-744104,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
19 EBI-744104,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
20 EBI-744104,EBI-2548012 BLZF1  
  .Golgi to plasma membrane protein transport
.cell proliferation
.Golgi organization
  + 3 more...
.ubiquitin protein ligase binding
.enzyme binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.Golgi lumen
.cytoplasm
.nucleoplasm
  + 2 more...
21 EBI-744104,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
22 EBI-744104,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
23 EBI-744104,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood24
bone55
bone marrow20
brain30
connective tissue53
ear62
embryonic tissue4
esophagus49
eye33
heart44
intestine17
kidney61
liver14
lung5
mammary gland6
muscle18
pancreas42
parathyroid48
pharynx24
pituitary gland60
placenta17
prostate15
skin14
stomach146
testis13
trachea38
umbilical cord72
uterus30
vascular96
Health State
TissuesTPM*
normal27
chondrosarcoma96
colorectal tumor17
esophageal tumor57
gastrointestinal tumor118
germ cell tumor34
glioma46
kidney tumor43
liver tumor31
lung tumor9
non-neoplasia93
pancreatic tumor28
prostate cancer9
skin tumor23
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult37
blastocyst16
neonate32
fetus17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25.5
adrenal gland57.6
appendix34.6
bone marrow1.8
cerebral cortex5.3
colon19.1
duodenum17
esophagus53.4
gallbladder200.6
heart muscle24.6
kidney13.7
liver18.2
lung21.3
lymph node20.3
ovary7.3
pancreas7.7
placenta5.8
prostate25.5
salivary gland8.8
skin2.6
small intestine20.8
spleen16.6
stomach12.1
testis4.4
thyroid gland5.3
urinary bladder75.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600164, gene) Gtp-binding mitogen-induced t-cell protein; GEMOMIM


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