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> Protein (NX_P55072)
Protein (NX_P55072)
Protein
Gene SymbolVCP to neXtProt (NX_P55072)
DescriptionTransitional endoplasmic reticulum ATPase
Chromosome9
Location9p13.3 (35056061 ~ 35073246) to Ensembl
Sequene Features : Isoforms 1, Variants 73, PTMs 47 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of Lys63-specific deubiquitinase activity
.positive regulation of protein K63-linked deubiquitination
.error-free translesion synthesis
  + 22 more...
.ubiquitin-specific protease binding
.poly(A) RNA binding
.ADP binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 73 47
2014-09-19protein level
1 58 47
2014-05-27protein level
1 58 48
2014-02-25protein level
1 58 42
2013-12-09protein level
1 52 42
2013-11-01protein level
1 50 40
2013-09-12protein level
1 50 39
2013-08-17protein level
1 50 40
2013-07-15protein level
1 28 19
2013-06-11protein level
1 28 19
2013-02-12protein level
1 12 28
2012-12-20protein level
1 13 28
2012-10-30protein level
1 16 27
2012-10-07protein level
1 16 27
2012-08-24protein level
1 13 27
2012-07-28protein level
1 13 27
2012-06-08protein level
1 20 27
2012-05-07protein level
1 18 27
2012-04-10protein level
1 18 27
2012-01-13protein level
1 17 27
2011-12-20protein level
1 17 27
2011-11-11protein level
1 17 25
2011-08-23protein level
1 15 19
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P55072-1
40 0 0 89265.4626
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-355164,EBI-1215612 FCHSD2  
  .N/A .N/A .N/A
2 EBI-355164,EBI-1180783 CHEK2  
  .replicative senescence
.mitotic spindle assembly
.signal transduction involved in intra-S DNA damage checkpoint
  + 18 more...
.metal ion binding
.protein homodimerization activity
.identical protein binding
  + 4 more...
.PML body
.Golgi apparatus
.nucleoplasm
3 EBI-355164,EBI-1047946 PTPN3  
  .regulation of sodium ion transmembrane transporter activity
.regulation of membrane depolarization during action potential
.liver regeneration
  + 4 more...
.ATPase binding
.sodium channel regulator activity
.protein tyrosine phosphatase activity
.phosphotyrosine binding
.cytoplasmic side of plasma membrane
.cytoskeleton
.cytoplasm
4 EBI-355164,EBI-946046 ATXN3  
  .cellular response to misfolded protein
.protein K48-linked deubiquitination
.protein K63-linked deubiquitination
  + 14 more...
.Lys48-specific deubiquitinase activity
.Lys63-specific deubiquitinase activity
.ATPase binding
  + 4 more...
.nuclear inclusion body
.mitochondrial membrane
.nuclear matrix
  + 5 more...
5 EBI-355164,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
6 EBI-355164,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
7 EBI-355164,EBI-723441 UBXN4  
  .ER-associated ubiquitin-dependent protein catabolic process
.response to unfolded protein
.N/A .endoplasmic reticulum membrane
.endoplasmic reticulum
.cytoplasm
.nuclear envelope
8 EBI-355164,EBI-1993677 ASPSCR1  
  .membrane organization
.regulation of glucose import
.glucose homeostasis
.intracellular protein transport
.N/A .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.endoplasmic reticulum-Golgi intermediate compartment membrane
  + 7 more...
9 EBI-355164,EBI-1993899 UBXN6  
  .N/A .N/A .extracellular exosome
.microtubule organizing center
.cytoplasm
  + 2 more...
10 EBI-355164,EBI-1046367 AMFR  
  .protein oligomerization
.endoplasmic reticulum unfolded protein response
.ER-associated ubiquitin-dependent protein catabolic process
  + 6 more...
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
  + 2 more...
.perinuclear region of cytoplasm
.protein complex
.neuronal cell body
  + 8 more...
11 EBI-355164,EBI-721577 NSFL1C  
  .membrane fusion
.regulation of catalytic activity
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 3 more...
.ubiquitin binding
.protein phosphatase type 1 regulator activity
.lipid binding
.intermediate filament cytoskeleton
.plasma membrane
.cytosol
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland455
ascites351
bladder234
blood310
bone349
bone marrow184
brain591
cervix371
connective tissue429
ear62
embryonic tissue488
esophagus248
eye272
heart346
intestine400
kidney469
larynx170
liver233
lung695
lymph1106
lymph node267
mammary gland284
mouth1965
muscle159
nerve128
ovary384
pancreas243
parathyroid242
pharynx98
pituitary gland302
placenta540
prostate511
salivary gland197
skin502
spleen786
stomach428
testis746
thymus966
thyroid257
tonsil352
trachea1062
umbilical cord72
uterus405
vascular735
Health State
TissuesTPM*
normal418
adrenal tumor553
bladder carcinoma511
breast (mammary gland) tumor354
cervical tumor376
chondrosarcoma615
colorectal tumor426
esophageal tumor289
gastrointestinal tumor371
germ cell tumor900
glioma354
head and neck tumor1105
kidney tumor522
leukemia296
liver tumor385
lung tumor447
lymphoma831
non-neoplasia341
ovarian tumor262
pancreatic tumor428
primitive neuroectodermal tumor of the CNS480
prostate cancer702
retinoblastoma366
skin tumor486
soft tissue/muscle tissue tumor279
uterine tumor455
Developmental Stage
TissuesTPM*
adult329
embryoid body457
blastocyst650
neonate708
fetus479
infant297
juvenile503
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue89.8
adrenal gland106.6
appendix116.5
bone marrow87.7
cerebral cortex72.4
colon81.8
duodenum77.1
esophagus88.4
gallbladder82.5
heart muscle108.9
kidney73.4
liver67.1
lung82
lymph node105.3
ovary73.4
pancreas32.4
placenta104
prostate99
salivary gland64.2
skin85
small intestine70.1
spleen89.5
stomach80.4
testis78.8
thyroid gland91.7
urinary bladder98.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumMedium
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#167320, phenotype) Inclusion body myopathy with early-onset paget disease and frontotemporalOMIM
2(*601023, gene) Valosin-containing protein; VCPOMIM
3(#613954, phenotype) Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia;OMIM


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