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> Protein (NX_P55081)
Protein (NX_P55081)
Protein
Gene SymbolMFAP1 to neXtProt (NX_P55081)
DescriptionMicrofibrillar-associated protein 1
Chromosome15
Location15q15.3 (44096690 ~ 44117000) to Ensembl
Sequene Features : Isoforms 1, Variants 43, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 43 16
2014-09-19protein level
1 35 16
2014-05-27protein level
1 35 16
2014-02-25protein level
1 34 16
2013-12-09protein level
1 26 16
2013-11-01protein level
1 26 14
2013-09-12protein level
1 26 14
2013-08-17protein level
1 26 14
2013-07-15protein level
1 18 11
2013-06-11protein level
1 18 11
2013-02-12protein level
1 9 12
2012-12-20protein level
1 11 12
2012-10-30protein level
1 14 12
2012-10-07protein level
1 14 12
2012-08-24protein level
1 9 12
2012-07-28protein level
1 9 12
2012-06-08protein level
1 13 12
2012-05-07protein level
1 13 12
2012-04-10protein level
1 13 12
2012-01-13protein level
1 13 12
2011-12-20protein level
1 13 12
2011-11-11protein level
1 13 12
2011-08-23protein level
1 13 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P55081-1
14 0 0 51926.479
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1048159,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
2 EBI-1048159,EBI-744322 PRPF3  
  .RNA splicing
.mRNA processing
.mRNA splicing, via spliceosome
  + 2 more...
.poly(A) RNA binding
.identical protein binding
.U4/U6 x U5 tri-snRNP complex
.nuclear speck
.Cajal body
  + 4 more...
3 EBI-1048159,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
4 EBI-1048159,EBI-742268 TADA2A  
  .histone H3 acetylation
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.chromatin organization
.zinc ion binding
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.chromosome
.nucleus
.PCAF complex
5 EBI-1048159,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
6 EBI-1048159,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
7 EBI-1048159,EBI-945751 COIL  
  .N/A .identical protein binding
.protein C-terminus binding
.membrane
.Cajal body
.cytoplasm
  + 3 more...
8 EBI-1048159,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
9 EBI-1048159,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
10 EBI-1048159,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
11 EBI-1048159,EBI-713456 IK  
  .cell-cell signaling
.immune response
.identical protein binding .nucleolus
.nucleoplasm
.extracellular space
12 EBI-1048159,EBI-2808286 CCDC57  
  .N/A .N/A .N/A
13 EBI-1048159,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
14 EBI-1048159,EBI-743722 GKAP1  
  .signal transduction .N/A .Golgi apparatus
15 EBI-1048159,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
16 EBI-1048159,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
17 EBI-1048159,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
18 EBI-1048159,EBI-1104570 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
19 EBI-1048159,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
20 EBI-1048159,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
21 EBI-1048159,EBI-10181188 BEND7  
  .N/A .N/A .extracellular exosome
22 EBI-1048159,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
23 EBI-1048159,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
24 EBI-1048159,EBI-8643207 ZNF398  
  .positive regulation of transcription, DNA-templated
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
25 EBI-1048159,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
26 EBI-1048159,EBI-5278764 CDCA7L  
  .positive regulation of cell proliferation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cytoplasm
.nucleolus
.nucleus
27 EBI-1048159,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
28 EBI-1048159,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
29 EBI-1048159,EBI-715394 KATNBL1  
  .N/A .N/A .nucleolus
30 EBI-1048159,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
31 EBI-1048159,EBI-745730 ZFP64  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
32 EBI-1048159,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
33 EBI-1048159,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
34 EBI-1048159,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
35 EBI-1048159,EBI-742610 MAD1L1  
  .regulation of metaphase plate congression
.cell division
.small GTPase mediated signal transduction
  + 4 more...
.N/A .mitotic spindle
.actin cytoskeleton
.cytosol
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites100
bladder33
blood49
bone27
bone marrow61
brain89
cervix82
connective tissue40
embryonic tissue65
esophagus148
eye38
heart33
intestine99
kidney90
larynx42
liver48
lung41
lymph135
lymph node33
mammary gland112
mouth105
muscle18
nerve64
ovary39
pancreas14
pharynx73
placenta70
prostate52
skin47
spleen18
stomach156
testis62
thymus125
thyroid42
tonsil117
trachea77
umbilical cord72
uterus77
vascular96
Health State
TissuesTPM*
normal65
breast (mammary gland) tumor96
cervical tumor57
chondrosarcoma24
colorectal tumor97
esophageal tumor115
gastrointestinal tumor92
germ cell tumor64
glioma27
head and neck tumor59
kidney tumor116
leukemia31
liver tumor52
lung tumor9
lymphoma96
non-neoplasia51
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS188
prostate cancer28
skin tumor55
soft tissue/muscle tissue tumor39
uterine tumor55
Developmental Stage
TissuesTPM*
adult62
embryoid body57
blastocyst81
neonate96
fetus55
infant510
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.2
adrenal gland20
appendix16.3
bone marrow7.4
cerebral cortex15.9
colon17.6
duodenum12
esophagus17.6
gallbladder15.7
heart muscle15.1
kidney19.7
liver11
lung14.2
lymph node24.3
ovary22.5
pancreas6.8
placenta20.6
prostate20.3
salivary gland11.1
skin16
small intestine12.3
spleen14.4
stomach13.8
testis20.2
thyroid gland23
urinary bladder21.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600215, gene) Microfibrillar-associated protein 1; MFAP1OMIM


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