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> Protein (NX_P55084)
Protein (NX_P55084)
Protein
Gene SymbolHADHB to neXtProt (NX_P55084)
DescriptionTrifunctional enzyme subunit beta, mitochondrial
Chromosome2
Location2p23.3 (26466038 ~ 26513336) to Ensembl
Sequene Features : Isoforms 2, Variants 74, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.glycerophospholipid biosynthetic process
.small molecule metabolic process
.cellular lipid metabolic process
  + 3 more...
.NAD binding
.poly(A) RNA binding
.long-chain-3-hydroxyacyl-CoA dehydrogenase activity
  + 5 more...
.extracellular exosome
.mitochondrial nucleoid
.mitochondrial fatty acid beta-oxidation multienzyme complex
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 74 17
2014-09-19protein level
2 63 17
2014-05-27protein level
2 63 17
2014-02-25protein level
1 63 11
2013-12-09protein level
1 53 11
2013-11-01protein level
1 52 8
2013-09-12protein level
1 52 4
2013-08-17protein level
1 52 4
2013-07-15protein level
1 39 4
2013-06-11protein level
1 39 4
2013-02-12protein level
1 26 4
2012-12-20protein level
1 25 4
2012-10-30protein level
1 25 4
2012-10-07protein level
1 25 4
2012-08-24protein level
1 25 4
2012-07-28protein level
1 23 4
2012-06-08protein level
1 24 4
2012-05-07protein level
1 24 4
2012-04-10protein level
1 24 4
2012-01-13protein level
1 24 4
2011-12-20protein level
1 24 4
2011-11-11protein level
1 24 4
2011-08-23protein level
1 24 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P55084-1
3 23 0 51261.3748
NX_P55084-2
1 23 0 48848.0809
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-356635,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland1335
ascites175
bladder267
blood204
bone195
bone marrow225
brain409
cervix226
connective tissue315
ear124
embryonic tissue98
esophagus595
eye148
heart1954
intestine336
kidney531
larynx42
liver326
lung143
lymph90
lymph node66
mammary gland152
mouth241
muscle441
nerve128
ovary98
pancreas70
parathyroid97
pharynx441
pituitary gland423
placenta254
prostate110
salivary gland49
skin185
spleen299
stomach229
testis291
thymus225
thyroid171
trachea193
umbilical cord363
uterus305
vascular387
Health State
TissuesTPM*
normal359
adrenal tumor395
bladder carcinoma284
breast (mammary gland) tumor204
cervical tumor173
chondrosarcoma265
colorectal tumor106
esophageal tumor695
gastrointestinal tumor177
germ cell tumor167
glioma93
head and neck tumor134
kidney tumor435
leukemia127
liver tumor343
lung tumor87
lymphoma83
non-neoplasia486
ovarian tumor118
pancreatic tumor76
primitive neuroectodermal tumor of the CNS385
prostate cancer48
retinoblastoma86
skin tumor159
soft tissue/muscle tissue tumor95
uterine tumor133
Developmental Stage
TissuesTPM*
adult172
embryoid body42
blastocyst97
neonate643
fetus123
infant425
juvenile431
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue88.8
adrenal gland156.9
appendix47.9
bone marrow35.8
cerebral cortex55.2
colon87.3
duodenum169.1
esophagus86
gallbladder60.6
heart muscle294.5
kidney140.5
liver127
lung49.2
lymph node48.9
ovary64.9
pancreas34.2
placenta48.4
prostate68.1
salivary gland69.5
skin51.9
small intestine143.4
spleen54.4
stomach59.3
testis59.8
thyroid gland83.4
urinary bladder76.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
breastMedium
bronchusLow
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyHigh
lateral ventricleLow
liverMedium
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandHigh
placentaLow
prostateLow
rectumMedium
salivary glandHigh
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
stomach 1High
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*143450, gene) Hydroxyacyl-coa dehydrogenase/3-ketoacyl-coa thiolase/enoyl-coa hydratase,OMIM
2(#609015, phenotype) Trifunctional protein deficiencyOMIM


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