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> Protein (NX_P55212)
Protein (NX_P55212)
Protein
Gene SymbolCASP6 to neXtProt (NX_P55212)
DescriptionCaspase-6
Chromosome4
Location4q25 (110609785 ~ 110624739) to Ensembl
Sequene Features : Isoforms 2, Variants 32, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.execution phase of apoptosis
.epithelial cell differentiation
.programmed cell death
  + 3 more...
.cysteine-type endopeptidase activity involved in execution phase of apoptosis
.identical protein binding
.cysteine-type peptidase activity
.cysteine-type endopeptidase activity
.cytosol
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 32 2
2014-09-19protein level
2 30 2
2014-05-27protein level
2 30 2
2014-02-25protein level
2 30 2
2013-12-09protein level
2 20 2
2013-11-01protein level
2 20 2
2013-09-12protein level
2 20 2
2013-08-17protein level
2 20 2
2013-07-15protein level
2 11 2
2013-06-11protein level
2 11 2
2013-02-12protein level
2 8 2
2012-12-20protein level
2 10 2
2012-10-30protein level
2 16 2
2012-10-07protein level
2 16 1
2012-08-24protein level
2 14 1
2012-07-28protein level
2 13 1
2012-06-08protein level
2 15 1
2012-05-07protein level
2 15 1
2012-04-10protein level
2 15 1
2012-01-13protein level
2 8 1
2011-12-20protein level
2 8 1
2011-11-11protein level
2 8 1
2011-08-23protein level
2 8 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P55212-1
6 9 0 33288.4037
NX_P55212-2
1 9 0 22559.1495
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-718729,EBI-743747 SATB1  
  .reflex
.activated T cell proliferation
.CD8-positive, alpha-beta T cell differentiation
  + 10 more...
.double-stranded DNA binding
.chromatin binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.PML body
.nuclear matrix
.nuclear heterochromatin
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites100
bladder66
blood16
bone marrow41
brain6
cervix41
embryonic tissue23
eye14
intestine12
kidney4
liver19
lung26
mammary gland19
muscle9
ovary19
pancreas4
pharynx98
placenta17
prostate15
salivary gland49
skin33
testis9
uterus12
Health State
TissuesTPM*
normal12
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor57
gastrointestinal tumor33
germ cell tumor26
glioma9
kidney tumor14
leukemia10
liver tumor20
lung tumor38
non-neoplasia31
ovarian tumor26
pancreatic tumor9
prostate cancer19
skin tumor39
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult12
embryoid body42
blastocyst32
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.5
adrenal gland5.5
appendix16.2
bone marrow9.3
cerebral cortex3
colon57.7
duodenum53.6
esophagus9
gallbladder16.8
heart muscle8
kidney14.8
liver11.2
lung14
lymph node14.4
ovary11.6
pancreas10.4
placenta8.6
prostate12.3
salivary gland11.5
skin13
small intestine50.2
spleen9.5
stomach21.4
testis4
thyroid gland15.6
urinary bladder23.3
Tissues
TissuesExpression level
appendixHigh
bone marrowLow
breastMedium
bronchusLow
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
fallopian tubeLow
gallbladderMedium
kidneyMedium
lymph nodeMedium
nasopharynxLow
ovaryMedium
pancreasMedium
placentaLow
prostateLow
rectumHigh
salivary glandLow
seminal vesicleLow
skin 1Low
skin 2Low
small intestineHigh
stomach 1High
stomach 2High
tonsilMedium
urinary bladderHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601532, gene) Caspase 6, apoptosis-related cysteine protease; CASP6OMIM


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