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> Protein (NX_P55884)
Protein (NX_P55884)
Protein
Gene SymbolEIF3B to neXtProt (NX_P55884)
DescriptionEukaryotic translation initiation factor 3 subunit B
Chromosome7
Location7p22.3 (2393721 ~ 2420380) to Ensembl
Sequene Features : Isoforms 2, Variants 76, PTMs 29 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular protein metabolic process
.gene expression
.regulation of translational initiation
  + 3 more...
.protein complex scaffold
.translation initiation factor activity
.nucleotide binding
.eukaryotic translation initiation factor 3 complex, eIF3m
.extracellular exosome
.eukaryotic 48S preinitiation complex
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 76 29
2014-09-19protein level
2 56 29
2014-05-27protein level
2 56 30
2014-02-25protein level
2 56 30
2013-12-09protein level
2 47 30
2013-11-01protein level
2 44 20
2013-09-12protein level
2 44 21
2013-08-17protein level
2 44 21
2013-07-15protein level
2 26 18
2013-06-11protein level
2 26 18
2013-02-12protein level
2 14 40
2012-12-20protein level
2 12 40
2012-10-30protein level
2 15 40
2012-10-07protein level
2 15 20
2012-08-24protein level
2 15 20
2012-07-28protein level
2 15 20
2012-06-08protein level
2 3 20
2012-05-07protein level
2 3 20
2012-04-10protein level
2 3 20
2012-01-13protein level
2 3 20
2011-12-20protein level
2 5 20
2011-11-11protein level
2 5 19
2011-08-23protein level
2 5 17
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P55884-1
1 35 0 92423.5613
NX_P55884-2
4 35 0 98966.8244
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-366696,EBI-711990 EIF3F  
  .cellular protein metabolic process
.protein deubiquitination
.gene expression
  + 4 more...
.ubiquitin-specific protease activity
.translation initiation factor activity
.eukaryotic 48S preinitiation complex
.eukaryotic 43S preinitiation complex
.membrane
  + 2 more...
2 EBI-366696,EBI-353779 DDX3X  
  .negative regulation of intrinsic apoptotic signaling pathway
.positive regulation of G1/S transition of mitotic cell cycle
.intrinsic apoptotic signaling pathway
  + 28 more...
.mRNA 5'-UTR binding
.poly(A) RNA binding
.CTPase activity
  + 14 more...
.extracellular exosome
.nuclear speck
.cytoplasmic stress granule
  + 4 more...
3 EBI-366696,EBI-366632 EIF3G  
  .cellular protein metabolic process
.gene expression
.regulation of translational initiation
  + 3 more...
.poly(A) RNA binding
.translation initiation factor activity
.nucleotide binding
.perinuclear region of cytoplasm
.eukaryotic 48S preinitiation complex
.eukaryotic 43S preinitiation complex
  + 3 more...
4 EBI-366696,EBI-366647 EIF3J  
  .cellular protein metabolic process
.gene expression
.regulation of translational initiation
  + 4 more...
.translation initiation factor activity .eukaryotic 48S preinitiation complex
.eukaryotic 43S preinitiation complex
.eukaryotic translation initiation factor 3 complex
.cytosol
5 EBI-366696,EBI-354047 EIF3I  
  .cellular protein metabolic process
.gene expression
.regulation of translational initiation
  + 3 more...
.translation initiation factor activity .eukaryotic translation initiation factor 3 complex, eIF3m
.extracellular exosome
.eukaryotic 48S preinitiation complex
  + 3 more...
6 EBI-366696,EBI-366617 EIF3A  
  .cellular protein metabolic process
.gene expression
.regulation of translational initiation
  + 4 more...
.poly(A) RNA binding
.structural molecule activity
.translation initiation factor activity
.eukaryotic translation initiation factor 3 complex, eIF3m
.eukaryotic 48S preinitiation complex
.eukaryotic 43S preinitiation complex
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites200
bladder133
blood163
bone251
bone marrow41
brain84
cervix288
connective tissue67
embryonic tissue169
esophagus248
eye162
heart78
intestine366
kidney166
larynx681
liver160
lung167
lymph496
lymph node89
mammary gland284
mouth362
muscle37
nerve321
ovary236
pancreas224
pharynx171
placenta148
prostate269
salivary gland296
skin317
spleen74
stomach125
testis130
thymus100
thyroid107
tonsil235
umbilical cord145
uterus228
vascular38
Health State
TissuesTPM*
normal98
adrenal tumor79
bladder carcinoma227
breast (mammary gland) tumor354
cervical tumor318
chondrosarcoma229
colorectal tumor559
esophageal tumor289
gastrointestinal tumor168
germ cell tumor212
glioma251
head and neck tumor388
kidney tumor275
leukemia74
liver tumor229
lung tumor272
lymphoma346
non-neoplasia51
ovarian tumor196
pancreatic tumor428
primitive neuroectodermal tumor of the CNS259
prostate cancer269
retinoblastoma215
skin tumor438
soft tissue/muscle tissue tumor167
uterine tumor255
Developmental Stage
TissuesTPM*
adult189
embryoid body114
blastocyst292
neonate128
fetus59
juvenile215
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue63.6
adrenal gland44.3
appendix62.3
bone marrow107.4
cerebral cortex34.1
colon53.1
duodenum46.2
esophagus60
gallbladder46.6
heart muscle34.8
kidney38.5
liver32.6
lung44
lymph node69.7
ovary55.9
pancreas38.4
placenta55.1
prostate48.9
salivary gland54.7
skin73.2
small intestine41.9
spleen56.9
stomach50.4
testis72.6
thyroid gland43.2
urinary bladder53.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleLow
soft tissue 1High
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603917, gene) Eukaryotic translation initiation factor 3, subunit b; EIF3BOMIM


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