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> Protein (NX_P55957)
Protein (NX_P55957)
Protein
Gene SymbolBID to neXtProt (NX_P55957)
DescriptionBH3-interacting domain death agonist
Chromosome22
Location22q11.21 (18216906 ~ 18257536) to Ensembl
Sequene Features : Isoforms 4, Variants 34, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.regulation of G1/S transition of mitotic cell cycle
  + 24 more...
.death receptor binding .extracellular exosome
.integral component of mitochondrial membrane
.membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 34 4
2014-09-19protein level
4 28 4
2014-05-27protein level
4 28 4
2014-02-25protein level
4 28 4
2013-12-09protein level
4 22 4
2013-11-01protein level
4 22 4
2013-09-12protein level
4 22 3
2013-08-17protein level
4 22 3
2013-07-15protein level
4 19 2
2013-06-11protein level
4 19 2
2013-02-12protein level
4 11 5
2012-12-20protein level
4 9 5
2012-10-30protein level
4 12 5
2012-10-07protein level
4 12 2
2012-08-24protein level
4 10 2
2012-07-28protein level
4 10 2
2012-06-08protein level
4 10 2
2012-05-07protein level
4 10 2
2012-04-10protein level
4 10 2
2012-01-13protein level
4 6 2
2011-12-20protein level
4 6 2
2011-11-11protein level
4 6 2
2011-08-23protein level
4 6 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P55957-1
0 10 0 21980.9821
NX_P55957-2
3 9 0 26819.3398
NX_P55957-3
4 3 0 14611.1028
NX_P55957-4
0 5 0 11255.9268
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10215147,EBI-2371423 AHCYL1  
  .response to calcium ion
.regulation of anion transport
.S-adenosylmethionine cycle
  + 6 more...
.hydrolase activity .extracellular exosome
.cytosol
.endoplasmic reticulum
2 EBI-519672,EBI-77694 BCL2  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 111 more...
.BH3 domain binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 6 more...
.pore complex
.myelin sheath
.nuclear membrane
  + 8 more...
3 EBI-519672,EBI-603614 CAV1  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.negative regulation of anoikis
  + 84 more...
.inward rectifier potassium channel inhibitor activity
.nitric-oxide synthase binding
.ion channel binding
  + 9 more...
.perinuclear region of cytoplasm
.membrane raft
.protein complex
  + 17 more...
4 EBI-519672,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
5 EBI-519672,EBI-516580 BAX  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of apoptotic signaling pathway
  + 87 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.BAX complex
.Bcl-2 family protein complex
.extracellular exosome
  + 10 more...
6 EBI-519672,EBI-78035 BCL2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 42 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 2 more...
.Bcl-2 family protein complex
.nuclear membrane
.synaptic vesicle membrane
  + 11 more...
7 EBI-519672,EBI-519866 BAK1  
  .positive regulation of IRE1-mediated unfolded protein response
.apoptotic process involved in patterning of blood vessels
.positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
  + 54 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
.identical protein binding
.pore complex
.integral component of mitochondrial outer membrane
.cytosol
  + 3 more...
8 EBI-519672,EBI-707714 BCL2L2  
  .negative regulation of intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.Sertoli cell proliferation
  + 3 more...
.protein heterodimerization activity
.protein homodimerization activity
.extracellular exosome
.cytosol
.mitochondrial outer membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites75
blood65
bone111
bone marrow61
brain54
cervix41
connective tissue6
embryonic tissue23
eye43
heart22
intestine38
kidney23
liver38
lung44
lymph node44
mammary gland13
ovary9
pancreas42
pituitary gland60
placenta10
prostate52
salivary gland49
skin47
stomach10
testis13
umbilical cord145
uterus25
vascular19
Health State
TissuesTPM*
normal34
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma96
colorectal tumor35
gastrointestinal tumor42
germ cell tumor34
glioma93
head and neck tumor7
kidney tumor29
leukemia31
liver tumor72
lung tumor29
lymphoma27
non-neoplasia41
ovarian tumor13
pancreatic tumor76
primitive neuroectodermal tumor of the CNS196
prostate cancer28
retinoblastoma43
skin tumor55
uterine tumor22
Developmental Stage
TissuesTPM*
adult37
embryoid body28
blastocyst48
neonate128
fetus39
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.1
adrenal gland6.3
appendix29.1
bone marrow56.2
cerebral cortex17.6
colon14.9
duodenum11.9
esophagus5.8
gallbladder15.2
heart muscle7.7
kidney6.4
liver15.3
lung12
lymph node32.9
ovary3
pancreas5
placenta7.9
prostate6.9
salivary gland5.8
skin5.4
small intestine16.6
spleen28.2
stomach12.9
testis3.4
thyroid gland5.3
urinary bladder22.9
Tissues
TissuesExpression level
appendixMedium
bone marrowMedium
colonMedium
duodenumLow
epididymisLow
heart muscleMedium
liverLow
lungLow
lymph nodeMedium
pancreasLow
prostateLow
rectumMedium
seminal vesicleLow
skeletal muscleMedium
skin 1Low
small intestineLow
spleenMedium
stomach 1Low
stomach 2Low
tonsilLow
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601997, gene) Bh3-interacting domain death agonist; BIDOMIM


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