Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P56279)
Protein (NX_P56279)
Protein
Gene SymbolTCL1A to neXtProt (NX_P56279)
DescriptionT-cell leukemia/lymphoma protein 1A
Chromosome14
Location14q32.13 (96176304 ~ 96180533) to Ensembl
Sequene Features : Isoforms 1, Variants 27, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.stem cell maintenance
.multicellular organismal development
.N/A .pronucleus
.cell cortex
.endoplasmic reticulum
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 27 0
2014-09-19protein level
1 23 0
2014-05-27protein level
1 23 0
2014-02-25protein level
1 23 0
2013-12-09protein level
1 22 0
2013-11-01protein level
1 21 0
2013-09-12protein level
1 21 0
2013-08-17protein level
1 21 0
2013-07-15protein level
1 17 0
2013-06-11protein level
1 17 0
2013-02-12protein level
1 7 0
2012-12-20protein level
1 7 0
2012-10-30protein level
1 7 0
2012-10-07protein level
1 7 0
2012-08-24protein level
1 5 0
2012-07-28protein level
1 5 0
2012-06-08protein level
1 12 0
2012-05-07protein level
1 12 0
2012-04-10protein level
1 12 0
2012-01-13protein level
1 10 0
2011-12-20protein level
1 10 0
2011-11-11protein level
1 10 0
2011-08-23protein level
1 11 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P56279-1
5 0 0 13450.894
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-749995,EBI-723239 WDR47  
  .multicellular organismal development .N/A .microtubule
.cytoplasm
2 EBI-749995,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
3 EBI-749995,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
4 EBI-749995,EBI-348239 LSM3  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.mRNA processing
  + 2 more...
.poly(A) RNA binding .catalytic step 2 spliceosome
.cytosol
.nucleus
5 EBI-749995,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
6 EBI-749995,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
7 EBI-749995,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
8 EBI-749995,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
9 EBI-749995,EBI-2555404 TTC33  
  .N/A .N/A .N/A
10 EBI-749995,EBI-750451 ALS2CR12  
  .regulation of GTPase activity .N/A .sperm flagellum
.sperm fibrous sheath
.outer dense fiber
11 EBI-749995,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
12 EBI-749995,EBI-739759 PRTFDC1  
  .nucleoside metabolic process .protein homodimerization activity
.magnesium ion binding
.nucleotide binding
.cytosol
13 EBI-749995,EBI-923653 DNMT3A  
  .C-5 methylation of cytosine
.cellular response to amino acid stimulus
.S-adenosylmethioninamine metabolic process
  + 15 more...
.DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
.metal ion binding
.unmethylated CpG binding
  + 5 more...
.nuclear matrix
.cytoplasm
.nuclear heterochromatin
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
bone13
bone marrow41
lung2
lymph4108
lymph node222
muscle56
pancreas4
placenta7
testis9
tonsil2996
Health State
TissuesTPM*
normal28
chondrosarcoma12
germ cell tumor7
leukemia42
lung tumor9
lymphoma2881
soft tissue/muscle tissue tumor47
Developmental Stage
TissuesTPM*
adult3
fetus16
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix33.6
bone marrow13.3
colon2.1
duodenum1.2
gallbladder3.1
liver1.1
lymph node224
salivary gland2.9
small intestine1.6
spleen61.1
stomach4.3
testis6.4
urinary bladder3.6
Tissues
TissuesExpression level
appendixHigh
bone marrowMedium
lungLow
lymph nodeHigh
spleenMedium
tonsilMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*186960, gene) T-cell leukemia/lymphoma 1a; TCL1AOMIM
2T-cell chronic lymphocytic leukaemiaCGP


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center