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> Protein (NX_P56377)
Protein (NX_P56377)
Protein
Gene SymbolAP1S2 to neXtProt (NX_P56377)
DescriptionAP-1 complex subunit sigma-2
ChromosomeX
LocationXp22.2 (15843929 ~ 15873054) to Ensembl
Sequene Features : Isoforms 2, Variants 11, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane organization
.regulation of defense response to virus by virus
.antigen processing and presentation of exogenous peptide antigen via MHC class II
  + 3 more...
.protein transporter activity .trans-Golgi network membrane
.clathrin-coated endocytic vesicle membrane
.cytoplasmic vesicle membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 11 1
2014-09-19protein level
2 7 1
2014-05-27protein level
2 7 1
2014-02-25protein level
2 7 1
2013-12-09protein level
1 5 1
2013-11-01protein level
1 5 0
2013-09-12protein level
1 5 0
2013-08-17protein level
1 5 0
2013-07-15protein level
1 1 0
2013-06-11protein level
1 1 0
2013-02-12protein level
1 0 0
2012-12-20protein level
1 0 0
2012-10-30protein level
1 0 0
2012-10-07protein level
1 0 0
2012-08-24protein level
1 0 0
2012-07-28protein level
1 0 0
2012-06-08protein level
1 4 0
2012-05-07protein level
1 5 0
2012-04-10protein level
1 5 0
2012-01-13protein level
1 4 0
2011-12-20protein level
1 4 0
2011-11-11protein level
1 4 0
2011-08-23protein level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P56377-1
3 4 2 18602.7152
NX_P56377-2
4 4 2 23209.9601
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1054374,EBI-10185819 AP1G1  
  .Golgi to lysosome transport
.membrane organization
.regulation of defense response to virus by virus
  + 8 more...
.GTP-dependent protein binding
.kinesin binding
.Rab GTPase binding
  + 2 more...
.recycling endosome
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 13 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites25
blood89
bone69
bone marrow20
brain175
cervix123
connective tissue174
ear186
embryonic tissue155
esophagus49
eye76
heart223
intestine81
kidney109
liver14
lung74
lymph node155
mammary gland26
muscle131
nerve64
ovary9
pancreas37
parathyroid194
pituitary gland60
placenta56
prostate21
skin241
spleen74
stomach52
testis110
thymus75
thyroid64
trachea57
uterus155
vascular135
Health State
TissuesTPM*
normal122
adrenal tumor237
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma36
colorectal tumor35
esophageal tumor57
gastrointestinal tumor8
germ cell tumor239
glioma111
head and neck tumor14
kidney tumor101
leukemia42
lung tumor19
lymphoma13
non-neoplasia227
ovarian tumor26
primitive neuroectodermal tumor of the CNS110
prostate cancer19
skin tumor143
soft tissue/muscle tissue tumor151
uterine tumor133
Developmental Stage
TissuesTPM*
adult88
embryoid body142
blastocyst179
neonate289
fetus159
infant170
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.4
adrenal gland17.1
appendix33.3
bone marrow28.1
cerebral cortex21.3
colon16.2
duodenum10.1
esophagus20.8
gallbladder18.2
heart muscle70.4
kidney10.3
liver5.1
lung20.6
lymph node29.2
ovary6.6
pancreas3.9
placenta23.6
prostate13.4
salivary gland4
skin11.7
small intestine12.1
spleen30.2
stomach9.1
testis22.8
thyroid gland12.7
urinary bladder26.1
Tissues
TissuesExpression level
adrenal glandMedium
bronchusLow
cerebellumMedium
cerebral cortexMedium
colonLow
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeLow
gallbladderMedium
heart muscleMedium
kidneyHigh
liverMedium
oral mucosaMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
rectumLow
seminal vesicleLow
skeletal muscleHigh
small intestineHigh
stomach 1Medium
stomach 2Medium
testisHigh
tonsilLow
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300629, gene) Adaptor-related protein complex 1, sigma-2 subunit; AP1S2OMIM
2(%304340, phenotype) Dandy-walker malformation with mental retardation, basal ganglia disease,OMIM


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