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> Protein (NX_P56524)
Protein (NX_P56524)
Protein
Gene SymbolHDAC4 to neXtProt (NX_P56524)
DescriptionHistone deacetylase 4
Chromosome2
Location2q37.3 (239969864 ~ 240323348) to Ensembl
Sequene Features : Isoforms 2, Variants 156, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.actomyosin
.A band
.neuromuscular junction
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 156 8
2014-09-19protein level
1 120 8
2014-05-27protein level
1 120 8
2014-02-25protein level
1 120 8
2013-12-09protein level
1 95 8
2013-11-01protein level
1 91 8
2013-09-12protein level
1 91 8
2013-08-17protein level
1 91 8
2013-07-15protein level
1 68 8
2013-06-11protein level
1 68 8
2013-02-12protein level
1 29 7
2012-12-20protein level
1 30 7
2012-10-30protein level
1 33 7
2012-10-07protein level
1 33 7
2012-08-24protein level
1 24 7
2012-07-28protein level
1 24 7
2012-06-08protein level
1 32 7
2012-05-07protein level
1 32 7
2012-04-10protein level
1 32 7
2012-01-13protein level
1 26 7
2011-12-20protein level
1 26 7
2011-11-11protein level
1 26 8
2011-08-23protein level
1 26 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P56524-1
8 36 2 118965.3597
NX_P56524-2
1 36 1 106300.7849
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-308629,EBI-373498 MIF4GD  
  .regulation of translation .protein C-terminus binding
.RNA binding
.cytoplasm
.nucleolus
2 EBI-308629,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
3 EBI-308629,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
4 EBI-308629,EBI-743414 EFEMP2  
  .extracellular matrix organization .calcium ion binding
.extracellular matrix structural constituent
.extracellular exosome
.vesicle
.basement membrane
.extracellular region
5 EBI-308629,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
6 EBI-308629,EBI-1170906 ATF2  
  .positive regulation of mitochondrial membrane permeability involved in apoptotic process
.adipose tissue development
.stress-activated MAPK cascade
  + 27 more...
.metal ion binding
.cAMP response element binding
.protein kinase binding
  + 13 more...
.site of double-strand break
.mitochondrial outer membrane
.cytoplasm
  + 2 more...
7 EBI-308629,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
8 EBI-308629,EBI-476295 SFN  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 20 more...
.protein kinase C inhibitor activity .extracellular exosome
.cytoplasmic vesicle membrane
.cytosol
  + 3 more...
9 EBI-308629,EBI-765407 BCL6  
  .negative regulation of cellular senescence
.positive regulation of cellular component movement
.regulation of immune response
  + 32 more...
.metal ion binding
.sequence-specific DNA binding
.chromatin DNA binding
  + 4 more...
.nucleus
10 EBI-308629,EBI-359832 YWHAG  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 14 more...
.poly(A) RNA binding
.protein kinase C inhibitor activity
.insulin-like growth factor receptor binding
.protein kinase C binding
.extracellular exosome
.cytoplasmic vesicle membrane
.membrane
  + 2 more...
11 EBI-308629,EBI-356498 YWHAE  
  .negative regulation of peptidyl-serine dephosphorylation
.regulation of potassium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 27 more...
.phosphoprotein binding
.phosphoserine binding
.protein heterodimerization activity
  + 7 more...
.extracellular exosome
.melanosome
.cytoplasmic vesicle membrane
  + 6 more...
12 EBI-308629,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
13 EBI-308629,EBI-80168 UBE2I  
  .positive regulation of SUMO transferase activity
.cell division
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 14 more...
.RING-like zinc finger domain binding
.SUMO conjugating enzyme activity
.poly(A) RNA binding
  + 6 more...
.sumoylated E2 ligase complex
.transferase complex
.synapse
  + 7 more...
14 EBI-308629,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
15 EBI-308629,EBI-306940 YWHAH  
  .regulation of sodium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
  + 16 more...
.protein heterodimerization activity
.ion channel binding
.glucocorticoid receptor binding
  + 4 more...
.extracellular exosome
.cytoplasmic vesicle membrane
.intercalated disc
  + 3 more...
16 EBI-308629,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
17 EBI-308629,EBI-925990 RUNX3  
  .positive regulation of extrinsic apoptotic signaling pathway
.negative regulation of epithelial cell proliferation
.peripheral nervous system neuron development
  + 14 more...
.ATP binding
.sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.RNA polymerase II regulatory region sequence-specific DNA binding
.intracellular membrane-bounded organelle
.Golgi apparatus
.cytoplasm
  + 3 more...
18 EBI-308629,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
19 EBI-308629,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
20 EBI-308629,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
21 EBI-308629,EBI-726876 RINT1  
  .regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
.regulation of ER to Golgi vesicle-mediated transport
.Golgi vesicle transport
  + 2 more...
.N/A .endoplasmic reticulum membrane
.endoplasmic reticulum
22 EBI-308629,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
23 EBI-308629,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
24 EBI-308629,EBI-10215533 ANKRA2  
  .regulation of transcription from RNA polymerase II promoter .low-density lipoprotein particle binding
.transcription cofactor activity
.membrane
.cytoskeleton
.cytosol
.nucleus
25 EBI-308629,EBI-714781 BRMS1  
  .positive regulation of anoikis
.positive regulation of protein deacetylation
.negative regulation of transcription, DNA-templated
  + 6 more...
.NF-kappaB binding
.histone deacetylase binding
.Sin3-type complex
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder33
blood40
bone13
brain15
connective tissue20
embryonic tissue23
eye19
heart11
intestine43
kidney28
liver14
lung32
mammary gland26
mouth30
muscle47
pancreas23
placenta17
prostate15
skin23
spleen18
stomach10
testis68
thymus50
thyroid21
tonsil58
uterus25
Health State
TissuesTPM*
normal18
breast (mammary gland) tumor42
chondrosarcoma12
colorectal tumor26
gastrointestinal tumor16
germ cell tumor11
glioma37
head and neck tumor14
kidney tumor29
leukemia52
liver tumor20
lung tumor19
lymphoma55
non-neoplasia20
pancreatic tumor47
skin tumor23
uterine tumor33
Developmental Stage
TissuesTPM*
adult20
blastocyst32
fetus17
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6
adrenal gland7.7
appendix6.3
bone marrow12.3
cerebral cortex8.9
colon5.4
duodenum3.7
esophagus14.3
gallbladder7.9
heart muscle6.2
kidney5
liver1.1
lung4.2
lymph node9.1
ovary6.6
pancreas2.9
placenta4.8
prostate4.5
salivary gland3.8
skin10.1
small intestine4.2
spleen5.6
stomach3.9
testis16.4
thyroid gland14.6
urinary bladder7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#600430, phenotype) Brachydactyly-mental retardation syndrome; BDMROMIM
2(*605314, gene) Histone deacetylase 4; HDAC4OMIM


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2014-2019 (C) Yonsei Proteome Research Center