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> Protein (NX_P56545)
Protein (NX_P56545)
Protein
Gene SymbolCTBP2 to neXtProt (NX_P56545)
DescriptionC-terminal-binding protein 2
Chromosome10
Location10q26.13 (126676421 ~ 126849739) to Ensembl
Sequene Features : Isoforms 2, Variants 154, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.white fat cell differentiation
.positive regulation of retinoic acid receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 5 more...
.NAD binding
.oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
.transcription corepressor activity
  + 2 more...
.synapse
.cell junction
.transcriptional repressor complex
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 154 3
2014-09-19protein level
2 127 3
2014-05-27protein level
2 127 4
2014-02-25protein level
2 125 2
2013-12-09protein level
2 70 2
2013-11-01protein level
2 67 2
2013-09-12protein level
2 67 2
2013-08-17protein level
2 67 2
2013-07-15protein level
2 54 1
2013-06-11protein level
2 54 1
2013-02-12protein level
2 38 5
2012-12-20protein level
2 33 5
2012-10-30protein level
2 56 5
2012-10-07protein level
2 56 4
2012-08-24protein level
2 51 4
2012-07-28protein level
2 51 4
2012-06-08protein level
2 57 4
2012-05-07protein level
2 57 4
2012-04-10protein level
2 57 4
2012-01-13protein level
2 63 4
2011-12-20protein level
2 63 4
2011-11-11protein level
2 63 4
2011-08-23protein level
2 63 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P56545-1
1 15 3 48913.9729
NX_P56545-2
21 15 3 106120.6163
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741533,EBI-983612 FOXP2  
  .positive regulation of epithelial cell proliferation involved in lung morphogenesis
.righting reflex
.smooth muscle tissue development
  + 12 more...
.metal ion binding
.sequence-specific DNA binding
.protein homodimerization activity
  + 4 more...
.nucleus
2 EBI-741533,EBI-714746 PPP1R15A  
  .positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
.negative regulation of PERK-mediated unfolded protein response
.positive regulation of peptidyl-serine dephosphorylation
  + 17 more...
.protein phosphatase type 1 activator activity
.protein kinase binding
.protein phosphatase type 1 regulator activity
.protein phosphatase 1 binding
.membrane
.cytosol
.Golgi apparatus
  + 6 more...
3 EBI-741533,EBI-10190763 NOL4  
  .N/A .RNA binding .nucleolus
.nucleus
4 EBI-741533,EBI-958997 BCL3  
  .maintenance of protein location in nucleus
.regulation of DNA binding
.spleen development
  + 29 more...
.protein binding, bridging
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.perinuclear region of cytoplasm
.intercellular bridge
.protein complex
  + 5 more...
5 EBI-741533,EBI-741406 CCNH  
  .positive regulation of viral transcription
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of gene expression, epigenetic
  + 20 more...
.cyclin-dependent protein serine/threonine kinase regulator activity
.kinase activity
.TFIIK complex
.cyclin-dependent protein kinase activating kinase holoenzyme complex
.holo TFIIH complex
  + 2 more...
6 EBI-741533,EBI-10171858 CTBP1  
  .negative regulation of transcription from RNA polymerase II promoter by histone modification
.negative regulation of histone H4 acetylation
.regulation of cell cycle
  + 9 more...
.repressing transcription factor binding
.NAD binding
.protein domain specific binding
  + 5 more...
.transcriptional repressor complex
.cytosol
.transcription factor complex
  + 2 more...
7 EBI-741533,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
8 EBI-741533,EBI-2507362 HIC1  
  .positive regulation of DNA damage response, signal transduction by p53 class mediator
.negative regulation of Wnt signaling pathway
.Wnt signaling pathway
  + 5 more...
.metal ion binding
.sequence-specific DNA binding
.histone deacetylase binding
.sequence-specific DNA binding transcription factor activity
.cytoplasm
.nucleoplasm
.chromatin
9 EBI-741533,EBI-714215 TGIF1  
  .retina development in camera-type eye
.negative regulation of retinoic acid receptor signaling pathway
.positive regulation of fibroblast proliferation
  + 14 more...
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 2 more...
.nucleoplasm
10 EBI-741533,EBI-10240029 ZNF750  
  .positive regulation of transcription from RNA polymerase II promoter
.cell differentiation
.epidermis development
.metal ion binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.core promoter sequence-specific DNA binding
.intracellular membrane-bounded organelle
.nucleolus
.nucleus
11 EBI-741533,EBI-3059266 FUNDC1  
  .response to hypoxia
.mitochondrion degradation
.N/A .integral component of mitochondrial outer membrane
.mitochondrial outer membrane
12 EBI-741533,EBI-3912635 PROX1  
  .positive regulation of forebrain neuron differentiation
.positive regulation of neural precursor cell proliferation
.positive regulation of cell cycle checkpoint
  + 53 more...
.LBD domain binding
.DBD domain binding
.transcription regulatory region DNA binding
  + 6 more...
.cytoplasm
.nucleus
13 EBI-741533,EBI-8833163 LCOR  
  .transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
14 EBI-741533,EBI-6660790 NOL4L  
  .N/A .N/A .cytoplasm
.nucleoplasm
15 EBI-741533,EBI-3396023 PLCB1  
  .positive regulation of CD24 biosynthetic process
.negative regulation of monocyte extravasation
.positive regulation of acrosome reaction
  + 30 more...
.protein homodimerization activity
.enzyme binding
.phosphatidylinositol-4,5-bisphosphate binding
  + 5 more...
.extracellular exosome
.nuclear membrane
.nuclear speck
  + 4 more...
16 EBI-741533,EBI-3893057 IKZF2  
  .positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
17 EBI-741533,EBI-3928516 SOX13  
  .regulation of gamma-delta T cell differentiation
.anatomical structure morphogenesis
.transcription, DNA-templated
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.nucleoplasm
.nucleus
18 EBI-741533,EBI-746228 RAI2  
  .embryo development .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
ascites50
bladder33
blood8
bone167
bone marrow164
brain33
cervix61
connective tissue26
ear62
embryonic tissue122
esophagus49
eye124
heart33
intestine137
kidney94
larynx85
liver19
lung119
lymph node11
mammary gland112
mouth45
muscle28
nerve128
ovary98
pancreas135
parathyroid145
placenta81
prostate142
skin85
spleen37
stomach41
testis96
thyroid64
trachea38
umbilical cord72
uterus112
Health State
TissuesTPM*
normal62
adrenal tumor79
breast (mammary gland) tumor161
cervical tumor86
chondrosarcoma96
colorectal tumor168
esophageal tumor57
gastrointestinal tumor42
germ cell tumor53
glioma9
head and neck tumor52
kidney tumor116
leukemia10
liver tumor31
lung tumor87
lymphoma13
non-neoplasia62
ovarian tumor118
pancreatic tumor257
primitive neuroectodermal tumor of the CNS39
prostate cancer144
retinoblastoma172
skin tumor63
soft tissue/muscle tissue tumor71
uterine tumor133
Developmental Stage
TissuesTPM*
adult83
embryoid body57
blastocyst162
neonate32
fetus59
infant85
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16
adrenal gland18.9
appendix14.6
bone marrow8.7
cerebral cortex13.8
colon32.4
duodenum22.3
esophagus17.4
gallbladder19
heart muscle10.7
kidney23.2
liver2.7
lung22
lymph node7
ovary28.3
pancreas16.2
placenta19.9
prostate33.4
salivary gland19.8
skin7.1
small intestine25.9
spleen19.2
stomach27.2
testis20.9
thyroid gland50
urinary bladder22.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602619, gene) C-terminal-binding protein 2; CTBP2OMIM


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