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> Protein (NX_P57060)
Protein (NX_P57060)
Protein
Gene SymbolRWDD2B to neXtProt (NX_P57060)
DescriptionRWD domain-containing protein 2B
Chromosome21
Location21q21.3 (30376705 ~ 30391699) to Ensembl
Sequene Features : Isoforms 1, Variants 42, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 42 0
2014-09-19protein level
1 32 0
2014-05-27protein level
1 32 0
2014-02-25protein level
1 32 0
2013-12-09protein level
1 24 0
2013-11-01protein level
1 24 0
2013-09-12protein level
1 24 0
2013-08-17protein level
1 24 0
2013-07-15protein level
1 19 0
2013-06-11protein level
1 19 0
2013-02-12protein level
1 11 0
2012-12-20protein level
1 12 0
2012-10-30protein level
1 12 0
2012-10-07protein level
1 12 0
2012-08-24protein level
1 9 0
2012-07-28protein level
1 9 0
2012-06-08protein level
1 9 0
2012-05-07protein level
1 9 0
2012-04-10protein level
1 9 0
2012-01-13protein level
1 4 0
2011-12-20protein level
1 4 0
2011-11-11protein level
1 4 0
2011-08-23protein level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P57060-1
15 0 0 36308.7837
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-724442,EBI-448202 GADD45G  
  .positive regulation of p38MAPK cascade
.regulation of cell cycle
.positive regulation of JNK cascade
  + 8 more...
.N/A .cytoplasm
.nucleus
2 EBI-724442,EBI-10197451 EPB41  
  .positive regulation of protein binding
.cortical actin cytoskeleton organization
.actin cytoskeleton organization
.blood circulation
.spectrin binding
.1-phosphatidylinositol binding
.structural constituent of cytoskeleton
.protein complex
.intracellular membrane-bounded organelle
.cortical cytoskeleton
  + 6 more...
3 EBI-724442,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
4 EBI-724442,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
5 EBI-724442,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
6 EBI-724442,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
7 EBI-724442,EBI-10181113 KIAA1958  
  .N/A .N/A .N/A
8 EBI-724442,EBI-739789 DVL3  
  .positive regulation of canonical Wnt signaling pathway
.planar cell polarity pathway involved in neural tube closure
.cochlea morphogenesis
  + 12 more...
.protein heterodimerization activity
.beta-catenin binding
.frizzled binding
  + 2 more...
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
bladder33
blood8
bone41
brain36
cervix82
connective tissue20
embryonic tissue4
esophagus49
eye14
heart44
intestine30
kidney33
larynx42
liver29
lung26
lymph node44
mammary gland46
mouth30
muscle56
ovary78
pancreas42
parathyroid48
pituitary gland60
placenta17
prostate15
skin42
spleen18
stomach20
testis52
thymus25
thyroid21
trachea19
uterus30
vascular135
Health State
TissuesTPM*
normal33
adrenal tumor79
breast (mammary gland) tumor64
cervical tumor115
chondrosarcoma72
colorectal tumor17
esophageal tumor57
gastrointestinal tumor16
germ cell tumor7
glioma55
head and neck tumor29
kidney tumor29
liver tumor52
lymphoma13
ovarian tumor78
pancreatic tumor38
primitive neuroectodermal tumor of the CNS70
prostate cancer9
skin tumor31
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult29
embryoid body14
fetus16
infant85
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.1
adrenal gland14.5
appendix8.9
bone marrow2.6
cerebral cortex7.2
colon12.3
duodenum9.5
esophagus12.9
gallbladder13.6
heart muscle13.5
kidney14.2
liver13.8
lung10
lymph node11.8
ovary8.6
pancreas10
placenta12.6
prostate15.4
salivary gland11.8
skin12.4
small intestine7.9
spleen9
stomach11.4
testis15.1
thyroid gland14.6
urinary bladder15.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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