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> Protein (NX_P57075)
Protein (NX_P57075)
Protein
Gene SymbolUBASH3A to neXtProt (NX_P57075)
DescriptionUbiquitin-associated and SH3 domain-containing protein A
Chromosome21
Location21q22.3 (43824008 ~ 43867791) to Ensembl
Sequene Features : Isoforms 3, Variants 113, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of T cell receptor signaling pathway
.regulation of cytokine production
.N/A .extracellular exosome
.cytosol
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 113 8
2014-09-19protein level
3 89 8
2014-05-27protein level
3 87 8
2014-02-25protein level
3 86 8
2013-12-09protein level
3 61 8
2013-11-01protein level
3 55 8
2013-09-12protein level
3 55 8
2013-08-17protein level
3 55 8
2013-07-15protein level
3 38 0
2013-06-11protein level
3 38 0
2013-02-12protein level
2 22 0
2012-12-20protein level
2 22 0
2012-10-30protein level
2 28 0
2012-10-07protein level
2 28 0
2012-08-24protein level
2 28 0
2012-07-28protein level
2 28 0
2012-06-08protein level
2 36 0
2012-05-07protein level
2 32 0
2012-04-10protein level
2 32 0
2012-01-13protein level
2 19 0
2011-12-20protein level
2 19 0
2011-11-11protein level
2 19 0
2011-08-23protein level
2 19 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P57075-1
4 28 0 74075.1397
NX_P57075-2
0 29 0 69745.8447
NX_P57075-3
2 23 0 59128.8371
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2105393,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
2 EBI-2105393,EBI-741602 TRIM37  
  .aggresome assembly
.protein autoubiquitination
.positive regulation of NF-kappaB transcription factor activity
  + 7 more...
.ubiquitin protein ligase activity
.protein homodimerization activity
.ubiquitin protein ligase binding
  + 5 more...
.perinuclear region of cytoplasm
.aggresome
.cytosol
  + 2 more...
3 EBI-2105393,EBI-740135 CBS  
  .hydrogen sulfide biosynthetic process
.oxidation-reduction process
.homocysteine metabolic process
  + 12 more...
.S-adenosyl-L-methionine binding
.modified amino acid binding
.nitric oxide binding
  + 11 more...
.intracellular membrane-bounded organelle
.cytosol
.nucleolus
.nucleus
4 EBI-2105393,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
5 EBI-2105393,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
6 EBI-2105393,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
7 EBI-2105393,EBI-348469 SF3B4  
  .positive regulation of mRNA splicing, via spliceosome
.gene expression
.RNA splicing
  + 3 more...
.poly(A) RNA binding
.nucleotide binding
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
8 EBI-2105393,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood81
connective tissue20
heart11
intestine4
liver9
mammary gland6
prostate10
spleen93
thymus75
thyroid21
Health State
TissuesTPM*
normal6
breast (mammary gland) tumor10
leukemia74
non-neoplasia31
Developmental Stage
TissuesTPM*
adult3
fetus7
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix7.6
bone marrow2.1
duodenum2.2
gallbladder2.3
lung2.3
lymph node14.3
salivary gland1.2
small intestine2.5
spleen5.9
stomach2.7
urinary bladder3.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605736, gene) Ubiquitin-associated and sh3 domain-containing protein a; UBASH3AOMIM


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