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> Protein (NX_P57077)
Protein (NX_P57077)
Protein
Gene SymbolMAP3K7CL to neXtProt (NX_P57077)
DescriptionMAP3K7 C-terminal-like protein
Chromosome21
Location21q21.3 (30449792 ~ 30548210) to Ensembl
Sequene Features : Isoforms 4, Variants 9, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .cytosol
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 9 0
2014-09-19protein level
4 19 0
2014-05-27protein level
4 19 0
2014-02-25protein level
4 9 0
2013-12-09protein level
4 3 0
2013-11-01protein level
4 3 0
2013-09-12protein level
4 3 0
2013-08-17protein level
4 3 0
2013-07-15protein level
4 3 0
2013-06-11protein level
4 3 0
2013-02-12protein level
4 3 0
2012-12-20protein level
4 6 0
2012-10-30protein level
4 6 0
2012-10-07protein level
4 6 0
2012-08-24protein level
4 6 0
2012-07-28protein level
4 6 0
2012-06-08protein level
4 9 0
2012-05-07protein level
4 9 0
2012-04-10protein level
4 9 0
2012-01-13protein level
4 5 0
2011-12-20protein level
4 5 0
2011-11-11protein level
4 4 0
2011-08-23protein level
4 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P57077-1
1 10 0 27230.7316
NX_P57077-2
1 5 0 15057.5165
NX_P57077-3
2 5 0 15951.0811
NX_P57077-4
2 5 0 16362.2725
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10215880,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
2 EBI-748831,EBI-713355 GPS2  
  .negative regulation of JNK cascade
.negative regulation of GTPase activity
.JNK cascade
  + 4 more...
.GTPase inhibitor activity
.transcription corepressor activity
.transcriptional repressor complex
.nucleoplasm
3 EBI-10215880,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
4 EBI-10215880,EBI-359964 TAB3  
  .nucleotide-binding oligomerization domain containing signaling pathway
.stress-activated MAPK cascade
.positive regulation of NF-kappaB transcription factor activity
  + 19 more...
.zinc ion binding .extracellular exosome
.endosome membrane
.plasma membrane
  + 3 more...
5 EBI-10215880,EBI-8466265 AK8  
  .ventricular system development
.nucleoside triphosphate biosynthetic process
.nucleoside diphosphate phosphorylation
.ATP binding
.nucleoside diphosphate kinase activity
.cytidylate kinase activity
.adenylate kinase activity
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood40
bone13
brain18
connective tissue26
eye4
kidney28
liver4
lung11
lymph node89
mammary gland6
muscle47
pancreas4
prostate5
skin18
stomach10
testis6
thymus25
uterus4
vascular58
Health State
TissuesTPM*
normal14
breast (mammary gland) tumor10
chondrosarcoma24
germ cell tumor15
glioma130
non-neoplasia41
pancreatic tumor9
skin tumor7
Developmental Stage
TissuesTPM*
adult10
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.4
adrenal gland6.7
appendix8.6
bone marrow4
cerebral cortex2
colon3.6
duodenum1.7
esophagus5
gallbladder9.3
heart muscle20.8
kidney3.7
liver3
lung5.8
lymph node8.6
ovary4.6
pancreas2.7
placenta3.9
prostate9.6
salivary gland1.5
skin4.2
small intestine3.1
spleen8.8
stomach2.9
testis3
thyroid gland2.7
urinary bladder9.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611110, gene) Chromosome 21 open reading frame 7; C21ORF7OMIM


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