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> Protein (NX_P57682)
Protein (NX_P57682)
Protein
Gene SymbolKLF3 to neXtProt (NX_P57682)
DescriptionKrueppel-like factor 3
Chromosome4
Location4p14 (38665817 ~ 38702663) to Ensembl
Sequene Features : Isoforms 2, Variants 52, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to peptide
.multicellular organismal development
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 52 8
2014-09-19protein level
2 37 8
2014-05-27protein level
2 37 8
2014-02-25protein level
2 37 8
2013-12-09protein level
2 30 8
2013-11-01protein level
2 29 8
2013-09-12protein level
2 29 9
2013-08-17protein level
2 29 9
2013-07-15protein level
2 23 9
2013-06-11protein level
2 23 9
2013-02-12protein level
2 11 19
2012-12-20protein level
2 11 19
2012-10-30protein level
2 12 19
2012-10-07protein level
2 12 10
2012-08-24protein level
2 10 10
2012-07-28protein level
2 10 10
2012-06-08protein level
2 13 10
2012-05-07protein level
2 10 10
2012-04-10protein level
2 10 10
2012-01-13protein level
2 8 10
2011-12-20protein level
2 8 10
2011-11-11protein level
2 8 7
2011-08-23protein level
2 8 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P57682-1
4 9 3 38803.4097
NX_P57682-2
1 9 0 25413.6843
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-8472267,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
2 EBI-8472267,EBI-741101 FHL3  
  .actin cytoskeleton organization
.muscle organ development
.zinc ion binding .Z disc
.focal adhesion
.nucleus
.stress fiber
3 EBI-8472267,EBI-8474075 LHX8  
  .odontogenesis of dentin-containing tooth
.forebrain neuron development
.female gonad development
  + 3 more...
.sequence-specific DNA binding
.zinc ion binding
.female germ cell nucleus
4 EBI-8472267,EBI-739789 DVL3  
  .positive regulation of canonical Wnt signaling pathway
.planar cell polarity pathway involved in neural tube closure
.cochlea morphogenesis
  + 12 more...
.protein heterodimerization activity
.beta-catenin binding
.frizzled binding
  + 2 more...
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites75
bladder66
blood57
bone41
bone marrow41
brain28
cervix41
connective tissue46
embryonic tissue32
eye9
heart67
intestine99
kidney23
larynx85
liver87
lung89
mammary gland26
mouth90
muscle47
ovary39
pancreas74
parathyroid339
placenta31
prostate21
skin28
spleen56
stomach52
testis4
trachea19
uterus133
vascular19
Health State
TissuesTPM*
normal49
cervical tumor57
chondrosarcoma96
colorectal tumor142
gastrointestinal tumor67
germ cell tumor45
glioma18
head and neck tumor52
kidney tumor43
leukemia63
liver tumor156
lung tumor19
non-neoplasia51
ovarian tumor52
pancreatic tumor66
prostate cancer19
skin tumor31
soft tissue/muscle tissue tumor31
uterine tumor122
Developmental Stage
TissuesTPM*
adult68
embryoid body85
neonate64
fetus80
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25.5
adrenal gland27
appendix25.1
bone marrow54.6
cerebral cortex15.3
colon47.6
duodenum36.6
esophagus43.4
gallbladder39.5
heart muscle11.9
kidney16.6
liver28
lung25.2
lymph node17.2
ovary32.5
pancreas17.1
placenta26.2
prostate24.6
salivary gland16
skin40
small intestine38.1
spleen27.3
stomach40.9
testis7.3
thyroid gland29.2
urinary bladder42
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609392, gene) Kruppel-like factor 3; KLF3OMIM


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