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> Protein (NX_P57739)
Protein (NX_P57739)
Protein
Gene SymbolCLDN2 to neXtProt (NX_P57739)
DescriptionClaudin-2
ChromosomeX
LocationXq22.3 (106143394 ~ 106174091) to Ensembl
Sequene Features : Isoforms 1, Variants 25, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules .identical protein binding
.structural molecule activity
.extracellular exosome
.integral component of membrane
.tight junction
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 25 2
2014-09-19protein level
1 19 2
2014-05-27protein level
1 19 2
2014-02-25protein level
1 19 2
2013-12-09protein level
1 18 2
2013-11-01protein level
1 18 2
2013-09-12protein level
1 18 2
2013-08-17protein level
1 18 2
2013-07-15protein level
1 13 1
2013-06-11protein level
1 13 1
2013-02-12protein level
1 6 1
2012-12-20protein level
1 6 1
2012-10-30protein level
1 6 1
2012-10-07protein level
1 6 1
2012-08-24protein level
1 6 0
2012-07-28protein level
1 6 0
2012-06-08protein level
1 4 0
2012-05-07protein level
1 4 0
2012-04-10protein level
1 4 0
2012-01-13protein level
1 0 0
2011-12-20protein level
1 0 0
2011-11-11protein level
1 0 0
2011-08-23protein level
1 0 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P57739-1
10 0 0 24532.5397
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-751440,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
2 EBI-751440,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
brain4
connective tissue6
eye4
intestine146
kidney199
liver9
lung5
mouth15
pancreas18
prostate36
stomach146
testis20
Health State
TissuesTPM*
normal12
chondrosarcoma12
colorectal tumor248
gastrointestinal tumor118
germ cell tumor41
head and neck tumor7
kidney tumor203
lung tumor9
non-neoplasia10
pancreatic tumor38
soft tissue/muscle tissue tumor39
Developmental Stage
TissuesTPM*
adult34
fetus14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland2.5
appendix2.2
colon3.9
duodenum18.2
gallbladder103.7
kidney114.6
liver23.7
lung1.5
small intestine21.9
stomach9.6
Tissues
TissuesExpression level
appendixLow
bronchusLow
cerebellumLow
cerebral cortexLow
colonLow
duodenumHigh
endometrium 1Low
gallbladderHigh
kidneyMedium
nasopharynxLow
pancreasLow
placentaMedium
seminal vesicleMedium
skin 1Low
small intestineMedium
soft tissue 1Low
stomach 1Medium
stomach 2Medium
tonsilLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300520, gene) Claudin 2; CLDN2OMIM


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