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> Protein (NX_P58340)
Protein (NX_P58340)
Protein
Gene SymbolMLF1 to neXtProt (NX_P58340)
DescriptionMyeloid leukemia factor 1
Chromosome3
Location3q25.32 (158288952 ~ 158325041) to Ensembl
Sequene Features : Isoforms 5, Variants 43, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell cycle arrest
.transcription, DNA-templated
.myeloid progenitor cell differentiation
.protein domain specific binding
.DNA binding
.cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 43 1
2014-09-19protein level
5 33 1
2014-05-27protein level
5 33 1
2014-02-25protein level
5 32 1
2013-12-09protein level
5 28 1
2013-11-01protein level
5 26 1
2013-09-12protein level
5 26 1
2013-08-17protein level
5 26 1
2013-07-15protein level
5 18 1
2013-06-11protein level
5 18 1
2013-02-12protein level
5 10 5
2012-12-20protein level
5 10 5
2012-10-30protein level
5 11 5
2012-10-07protein level
4 11 1
2012-08-24protein level
4 9 1
2012-07-28protein level
4 9 1
2012-06-08protein level
4 11 1
2012-05-07protein level
4 8 1
2012-04-10protein level
1 8 0
2012-01-13protein level
1 9 0
2011-12-20protein level
1 9 0
2011-11-11protein level
1 9 0
2011-08-23protein level
1 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P58340-1
1 10 0 30607.9028
NX_P58340-2
0 8 0 23102.4207
NX_P58340-3
2 10 0 33866.7085
NX_P58340-4
0 10 0 29077.1855
NX_P58340-5
0 10 0 27607.5573
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-721328,EBI-1053164 DNAJB6  
  .regulation of cellular response to heat
.negative regulation of inclusion body assembly
.chorion development
  + 11 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
  + 2 more...
.perinuclear region of cytoplasm
.Z disc
.membrane
  + 4 more...
2 EBI-721328,EBI-356498 YWHAE  
  .negative regulation of peptidyl-serine dephosphorylation
.regulation of potassium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 27 more...
.phosphoprotein binding
.phosphoserine binding
.protein heterodimerization activity
  + 7 more...
.extracellular exosome
.melanosome
.cytoplasmic vesicle membrane
  + 6 more...
3 EBI-721328,EBI-357648 PSMD2  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 21 more...
.enzyme regulator activity .extracellular exosome
.proteasome accessory complex
.membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder368
bone55
bone marrow20
brain23
connective tissue20
embryonic tissue9
eye4
heart134
intestine21
kidney23
larynx42
liver14
lung56
mammary gland33
mouth15
muscle150
nerve128
ovary59
parathyroid145
pharynx171
placenta7
prostate26
salivary gland49
skin47
testis278
uterus12
Health State
TissuesTPM*
normal48
bladder carcinoma625
breast (mammary gland) tumor32
chondrosarcoma48
gastrointestinal tumor8
germ cell tumor37
glioma18
head and neck tumor14
kidney tumor14
leukemia10
liver tumor10
lung tumor19
ovarian tumor78
primitive neuroectodermal tumor of the CNS31
prostate cancer9
skin tumor79
soft tissue/muscle tissue tumor39
uterine tumor33
Developmental Stage
TissuesTPM*
adult24
embryoid body28
fetus44
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.3
adrenal gland9.1
appendix3.6
bone marrow1.9
cerebral cortex16
colon6.8
duodenum2.2
esophagus13.8
gallbladder16.9
heart muscle118.3
kidney13.9
liver2.2
lung18.1
lymph node2.9
ovary12.3
pancreas5.6
placenta2.8
prostate4.9
salivary gland4.4
skin3.9
small intestine2.3
spleen1.9
stomach5.1
testis297.7
thyroid gland16.1
urinary bladder7.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601402, gene) Myeloid leukemia factor 1; MLF1OMIM
2acute myelogenous leukemiaCGP


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