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> Protein (NX_P60228)
Protein (NX_P60228)
Protein
Gene SymbolEIF3E to neXtProt (NX_P60228)
DescriptionEukaryotic translation initiation factor 3 subunit E
Chromosome8
Location8q23.1 (109213445 ~ 109447562) to Ensembl
Sequene Features : Isoforms 1, Variants 63, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of translational initiation
.cellular protein metabolic process
.gene expression
  + 5 more...
.protein N-terminus binding
.poly(A) RNA binding
.translation initiation factor activity
.extracellular exosome
.eukaryotic 48S preinitiation complex
.PML body
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 63 11
2014-09-19protein level
1 55 11
2014-05-27protein level
1 55 12
2014-02-25protein level
1 55 12
2013-12-09protein level
1 47 13
2013-11-01protein level
1 47 11
2013-09-12protein level
1 47 10
2013-08-17protein level
1 47 10
2013-07-15protein level
1 28 3
2013-06-11protein level
1 28 3
2013-02-12protein level
1 10 5
2012-12-20protein level
1 11 5
2012-10-30protein level
1 13 5
2012-10-07protein level
1 13 5
2012-08-24protein level
1 5 5
2012-07-28protein level
1 5 5
2012-06-08protein level
1 6 5
2012-05-07protein level
1 6 5
2012-04-10protein level
1 6 5
2012-01-13protein level
1 6 5
2011-12-20protein level
1 6 5
2011-11-11protein level
1 6 5
2011-08-23protein level
1 6 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P60228-1
26 0 0 52187.2413
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-347740,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-347740,EBI-747225 RUNDC3A  
  .small GTPase mediated signal transduction .GTPase regulator activity
.guanylate cyclase activator activity
.plasma membrane
.cytosol
3 EBI-347740,EBI-524753 ZDHHC17  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.lipoprotein transport
.protein palmitoylation
  + 2 more...
.identical protein binding
.protein-cysteine S-palmitoyltransferase activity
.palmitoyltransferase activity
  + 3 more...
.intracellular membrane-bounded organelle
.Golgi-associated vesicle membrane
.integral component of membrane
  + 3 more...
4 EBI-347740,EBI-10216552 C4orf19  
  .N/A .N/A .N/A
5 EBI-347740,EBI-447470 EPAS1  
  .cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.iron ion homeostasis
  + 18 more...
.protein heterodimerization activity
.histone acetyltransferase binding
.transcription factor binding
  + 4 more...
.nuclear speck
.cytosol
.transcription factor complex
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland151
ascites150
bladder636
blood302
bone363
bone marrow1395
brain156
cervix329
connective tissue335
ear496
embryonic tissue558
esophagus297
eye287
heart245
intestine206
kidney194
larynx42
liver292
lung197
lymph248
lymph node300
mammary gland330
mouth30
muscle470
nerve386
ovary256
pancreas196
parathyroid242
pharynx540
pituitary gland544
placenta204
prostate374
salivary gland1579
skin227
spleen168
stomach209
testis273
thymus100
thyroid236
trachea135
umbilical cord363
uterus417
vascular387
Health State
TissuesTPM*
normal197
adrenal tumor237
bladder carcinoma966
breast (mammary gland) tumor483
cervical tumor347
chondrosarcoma253
colorectal tumor266
esophageal tumor231
gastrointestinal tumor236
germ cell tumor543
glioma289
head and neck tumor82
kidney tumor217
leukemia783
liver tumor426
lung tumor330
lymphoma304
non-neoplasia227
ovarian tumor223
pancreatic tumor209
primitive neuroectodermal tumor of the CNS401
prostate cancer568
retinoblastoma861
skin tumor279
soft tissue/muscle tissue tumor590
uterine tumor466
Developmental Stage
TissuesTPM*
adult195
embryoid body485
blastocyst455
neonate193
fetus183
infant680
juvenile305
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue134.5
adrenal gland184
appendix159.2
bone marrow187.1
cerebral cortex66.2
colon157.9
duodenum157.8
esophagus202.8
gallbladder202
heart muscle131.9
kidney129.8
liver82
lung117.4
lymph node269.9
ovary408
pancreas128.2
placenta146
prostate149.5
salivary gland205
skin175.4
small intestine149.2
spleen136.9
stomach132.1
testis91.4
thyroid gland211.1
urinary bladder245.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisLow
esophagusHigh
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleLow
skin 1Medium
skin 2Medium
small intestineMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2High
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602210, gene) Eukaryotic translation initiation factor 3, subunit e; EIF3EOMIM


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