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> Protein (NX_P60370)
Protein (NX_P60370)
Protein
Gene SymbolKRTAP10-5 to neXtProt (NX_P60370)
DescriptionKeratin-associated protein 10-5
Chromosome21
Location21q22.3 (45999332 ~ 46000481) to Ensembl
Sequene Features : Isoforms 1, Variants 61, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .identical protein binding .keratin filament
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 61 0
2014-09-19protein level
1 50 0
2014-05-27transcript level
1 50 0
2014-02-25transcript level
1 49 0
2013-12-09transcript level
1 37 0
2013-11-01transcript level
1 37 0
2013-09-12transcript level
1 37 0
2013-08-17transcript level
1 37 0
2013-07-15transcript level
1 26 0
2013-06-11transcript level
1 26 0
2013-02-12transcript level
1 16 0
2012-12-20transcript level
1 13 0
2012-10-30transcript level
1 15 0
2012-10-07transcript level
1 15 0
2012-08-24transcript level
1 14 0
2012-07-28transcript level
1 14 0
2012-06-08transcript level
1 14 0
2012-05-07transcript level
1 14 0
2012-04-10transcript level
1 14 0
2012-01-13transcript level
1 13 0
2011-12-20transcript level
1 13 0
2011-11-11transcript level
1 13 0
2011-08-23transcript level
1 13 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P60370-1
3 0 0 27604.6824
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10172150,EBI-10172129 MT1DP  
  .N/A .metal ion binding .N/A
2 EBI-10172150,EBI-10173019 ZNF320  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
3 EBI-10172150,EBI-3925400 ZNF785  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
4 EBI-10172150,EBI-744471 ZBTB24  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
5 EBI-10172150,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
6 EBI-10172150,EBI-3866665 SPRY1  
  .negative regulation of ERK1 and ERK2 cascade
.bud elongation involved in lung branching
.negative regulation of neurotrophin TRK receptor signaling pathway
  + 10 more...
.N/A .plasma membrane
.cytosol
7 EBI-10172150,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
8 EBI-10172150,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
9 EBI-10172150,EBI-5357290 TULP3  
  .negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
.ganglion development
.smoothened signaling pathway involved in dorsal/ventral neural tube patterning
  + 14 more...
.phosphatidylinositol binding
.protein complex binding
.enzyme binding
.phosphatidylinositol-4,5-bisphosphate binding
.ciliary base
.primary cilium
.axoneme
  + 5 more...
10 EBI-10172150,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
11 EBI-10172150,EBI-374781 GLRX3  
  .cell redox homeostasis
.negative regulation of cardiac muscle hypertrophy
.regulation of the force of heart contraction
.iron-sulfur cluster binding
.metal ion binding
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.Z disc
.cell cortex
12 EBI-10172150,EBI-2513774 FARS2  
  .gene expression
.tRNA processing
.phenylalanyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.phenylalanine-tRNA ligase activity
.magnesium ion binding
.tRNA binding
.mitochondrial matrix
.mitochondrion
13 EBI-10172150,EBI-10196781 KRTAP2-3  
  .N/A .N/A .keratin filament
14 EBI-10172150,EBI-744864 ZBTB48  
  .transcription, DNA-templated .metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleoplasm
15 EBI-10172150,EBI-3909284 GATA1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of transcription regulatory region DNA binding
.cellular response to thyroid hormone stimulus
  + 26 more...
.C2H2 zinc finger domain binding
.sequence-specific DNA binding
.chromatin DNA binding
  + 12 more...
.transcriptional repressor complex
.transcription factor complex
.nucleoplasm
.nucleus
16 EBI-10172150,EBI-717634 ZNF20  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
17 EBI-10172150,EBI-1965483 ZNF32  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
18 EBI-10172150,EBI-721550 NR4A1  
  .phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 13 more...
.sequence-specific DNA binding
.zinc ion binding
.ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 2 more...
.nuclear membrane
.cytoplasm
.nucleoplasm
.nucleus
19 EBI-10172150,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
20 EBI-10172150,EBI-740446 OTX1  
  .diencephalon morphogenesis
.positive regulation of transcription from RNA polymerase II promoter
.inner ear morphogenesis
  + 3 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
21 EBI-10172150,EBI-749311 HPCAL1  
  .signal transduction .calcium ion binding .extracellular exosome
22 EBI-10172150,EBI-747693 NAA10  
  .N-terminal peptidyl-glutamic acid acetylation
.N-terminal peptidyl-serine acetylation
.internal protein amino acid acetylation
  + 2 more...
.peptide-glutamate-N-acetyltransferase activity
.peptide-serine-N-acetyltransferase activity
.N-acetyltransferase activity
.NatA complex
.cytosolic ribosome
.membrane
  + 4 more...
23 EBI-10172150,EBI-2859983 ECE1  
  .pharyngeal system development
.ear development
.embryonic digit morphogenesis
  + 11 more...
.metal ion binding
.protein homodimerization activity
.peptide hormone binding
  + 2 more...
.extracellular exosome
.perinuclear region of cytoplasm
.Weibel-Palade body
  + 9 more...
24 EBI-10172150,EBI-2558314 ALDH3B1  
  .oxidation-reduction process
.aldehyde catabolic process
.cellular response to oxidative stress
  + 3 more...
.aldehyde dehydrogenase [NAD(P)+] activity
.3-chloroallyl aldehyde dehydrogenase activity
.extracellular exosome
.vesicle
.plasma membrane
  + 2 more...
25 EBI-10172150,EBI-740785 HOXA1  
  .cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
26 EBI-10172150,EBI-750494 SMCP  
  .sperm motility
.penetration of zona pellucida
.N/A .mitochondrial membrane
.mitochondrion
.cytoplasm
27 EBI-10172150,EBI-10211940 MXI1  
  .cytoplasmic sequestering of transcription factor
.negative regulation of cell proliferation
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
28 EBI-10172150,EBI-10210845 KRTAP12-1  
  .N/A .N/A .keratin filament
29 EBI-10172150,EBI-10176379 KRTAP12-2  
  .N/A .N/A .keratin filament
30 EBI-10172150,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
31 EBI-10172150,EBI-10192698 CREB5  
  .adipose tissue development
.positive regulation of transcription, DNA-templated
.fat cell differentiation
.transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.extracellular exosome
.nucleus
32 EBI-10172150,EBI-747421 HHEX  
  .primitive streak formation
.DNA conformation change
.hepatocyte differentiation
  + 34 more...
.repressing transcription factor binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 8 more...
.protein-DNA complex
.cytoplasm
.nucleus
33 EBI-10172150,EBI-10223946 WT1-AS  
  .N/A .N/A .N/A
34 EBI-10172150,EBI-10181276 GOLGA8DP  
  .N/A .N/A .Golgi apparatus
35 EBI-10172150,EBI-10230628 MOBP  
  .nervous system development .structural constituent of myelin sheath .perinuclear region of cytoplasm
.mitochondrion
36 EBI-10172150,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
37 EBI-10172150,EBI-3922471 ZNF273  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
38 EBI-10172150,EBI-3920053 ZSCAN26  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.nucleic acid binding
.nucleus
39 EBI-10172150,EBI-10240849 ZNF792  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
40 EBI-10172150,EBI-10243533 -  
  .N/A .N/A .N/A
41 EBI-10172150,EBI-751192 FAM76B  
  .protein deneddylation .NEDD8-specific protease activity .nuclear membrane
.nuclear speck
.cytoplasm
  + 2 more...
42 EBI-10172150,EBI-10245291 LCE3C  
  .keratinization .N/A .N/A
43 EBI-10172150,EBI-10245456 LCE3E  
  .keratinization .N/A .N/A
44 EBI-10172150,EBI-10245913 LCE1B  
  .keratinization .N/A .N/A
45 EBI-10172150,EBI-10246358 LCE4A  
  .keratinization .N/A .N/A
46 EBI-10172150,EBI-10246607 LCE2A  
  .keratinization .N/A .N/A
47 EBI-10172150,EBI-10246750 LCE2D  
  .keratinization .N/A .N/A
48 EBI-10172150,EBI-10247271 FAM74A6  
  .N/A .N/A .N/A
49 EBI-10172150,EBI-10248413 -  
  .N/A .N/A .N/A
50 EBI-10172150,EBI-949753 TENC1  
  .multicellular organismal homeostasis
.intracellular signal transduction
.multicellular organism growth
  + 5 more...
.metal ion binding
.kinase binding
.phosphoprotein phosphatase activity
.focal adhesion
.plasma membrane
51 EBI-10172150,EBI-10250562 KRTAP5-6  
  .N/A .N/A .keratin filament
52 EBI-10172150,EBI-6660291 C11orf87  
  .N/A .N/A .integral component of membrane
53 EBI-10172150,EBI-1051531 DHX57  
  .RNA processing .metal ion binding
.poly(A) RNA binding
.ATP binding
.ATP-dependent RNA helicase activity
.mitochondrion
.nucleus
54 EBI-10172150,EBI-3957672 KRTAP26-1  
  .N/A .N/A .intermediate filament
55 EBI-10172150,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
56 EBI-10172150,EBI-10257016 ZNF572  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
57 EBI-10172150,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
58 EBI-10172150,EBI-10257651 LIMS2  
  .positive regulation of integrin-mediated signaling pathway
.negative regulation of hepatocyte proliferation
.negative regulation of neural precursor cell proliferation
  + 4 more...
.zinc ion binding .focal adhesion
.plasma membrane
.cytosol
.nucleus
59 EBI-10172150,EBI-7233259 ZNF329  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
60 EBI-10172150,EBI-745567 ZNF679  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
61 EBI-10172150,EBI-10264496 ZNF34  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.zinc ion binding
.DNA binding
.nucleus
62 EBI-10172150,EBI-10267553 ZNF433  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
63 EBI-10172150,EBI-747580 ZNF439  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
64 EBI-10172150,EBI-741032 CNNM3  
  .ion transport .N/A .integral component of membrane
.membrane
.plasma membrane
65 EBI-10172150,EBI-742060 TYMSOS  
  .N/A .N/A .N/A
66 EBI-10172150,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
67 EBI-10172150,EBI-8637627 AEN  
  .nucleic acid phosphodiester bond hydrolysis
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to ionizing radiation
.exonuclease activity
.nucleic acid binding
.nuclear membrane
.nucleolus
.nucleoplasm
.nucleus
68 EBI-10172150,EBI-718419 PVRL2  
  .susceptibility to T cell mediated cytotoxicity
.establishment of mitochondrion localization
.regulation of immune response
  + 22 more...
.cell adhesion molecule binding
.protein homodimerization activity
.identical protein binding
  + 2 more...
.extracellular exosome
.integral component of membrane
.cell surface
  + 4 more...
69 EBI-10172150,EBI-748111 ZNF707  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
70 EBI-10172150,EBI-722584 C9orf9  
  .N/A .N/A .cytoplasmic microtubule
.acrosomal vesicle
71 EBI-10172150,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
72 EBI-10172150,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
73 EBI-10172150,EBI-2849569 ZFYVE21  
  .N/A .metal ion binding .cytoplasmic membrane-bounded vesicle
.focal adhesion
.endosome
74 EBI-10172150,EBI-739863 KRTAP4-12  
  .N/A .N/A .keratin filament
75 EBI-10172150,EBI-746605 ZNF559  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
76 EBI-10172150,EBI-5457544 UTP23  
  .maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) .small ribosomal subunit rRNA binding
.poly(A) RNA binding
.small-subunit processome
.nucleolus
77 EBI-10172150,EBI-745276 ZNF670  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
78 EBI-10172150,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
79 EBI-10172150,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
80 EBI-10172150,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
81 EBI-10172150,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
82 EBI-10172150,EBI-751260 KRTAP3-2  
  .N/A .structural molecule activity .keratin filament
83 EBI-10172150,EBI-744099 ENKD1  
  .N/A .N/A .microtubule cytoskeleton
.cytoplasmic microtubule
84 EBI-10172150,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
85 EBI-10172150,EBI-947551 CHRD  
  .positive regulation of cell adhesion
.negative regulation of osteoblast differentiation
.floor plate development
  + 9 more...
.cytokine binding
.heparin binding
.extracellular space
86 EBI-10172150,EBI-10310244 ZNF286A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
87 EBI-10172150,EBI-10311198 SLC6A20  
  .transmembrane transport
.proline transport
.glycine transport
  + 3 more...
.amino acid transmembrane transporter activity
.neurotransmitter:sodium symporter activity
.apical plasma membrane
.integral component of plasma membrane
.plasma membrane
88 EBI-10172150,EBI-748927 NPDC1  
  .N/A .N/A .integral component of membrane
89 EBI-10172150,EBI-10313866 C19orf66  
  .N/A .N/A .N/A
90 EBI-10172150,EBI-740924 PRR13  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .nucleus
91 EBI-10172150,EBI-10198848 LUZP4  
  .N/A .N/A .nucleus
92 EBI-10172150,EBI-745404 THAP10  
  .N/A .metal ion binding
.DNA binding
.N/A
93 EBI-10172150,EBI-1759386 SLC23A1  
  .transepithelial L-ascorbic acid transport
.dehydroascorbic acid transport
.small molecule metabolic process
  + 12 more...
.sodium-dependent L-ascorbate transmembrane transporter activity
.dehydroascorbic acid transporter activity
.L-ascorbic acid transporter activity
  + 3 more...
.extracellular exosome
.intracellular organelle
.apical plasma membrane
  + 6 more...
94 EBI-10172150,EBI-4291090 GNE  
  .carbohydrate phosphorylation
.cellular protein metabolic process
.post-translational protein modification
  + 6 more...
.metal ion binding
.N-acylmannosamine kinase activity
.UDP-N-acetylglucosamine 2-epimerase activity
  + 2 more...
.cytosol
.cytoplasm
95 EBI-10172150,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
96 EBI-10172150,EBI-10281938 ZSCAN21  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of transcription, DNA-templated
.metal ion binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus


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