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> Protein (NX_P60484)
Protein (NX_P60484)
Protein
Gene SymbolPTEN to neXtProt (NX_P60484)
DescriptionPhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Chromosome10
Location10q23.31 (89622870 ~ 89731687) to Ensembl
Sequene Features : Isoforms 3, Variants 657, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of apoptotic signaling pathway
.negative regulation of synaptic vesicle clustering
.positive regulation of excitatory postsynaptic membrane potential
  + 91 more...
.phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
.inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
.PDZ domain binding
  + 10 more...
.postsynaptic membrane
.Schmidt-Lanterman incisure
.dendritic spine
  + 12 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 657 12
2014-09-19protein level
3 603 12
2014-05-27protein level
1 603 12
2014-02-25protein level
1 392 12
2013-12-09protein level
1 392 12
2013-11-01protein level
1 392 12
2013-09-12protein level
1 392 11
2013-08-17protein level
1 392 11
2013-07-15protein level
1 392 10
2013-06-11protein level
1 392 10
2013-02-12protein level
1 392 11
2012-12-20protein level
1 392 11
2012-10-30protein level
1 392 11
2012-10-07protein level
1 392 11
2012-08-24protein level
1 382 11
2012-07-28protein level
1 383 11
2012-06-08protein level
1 99 11
2012-05-07protein level
1 99 11
2012-04-10protein level
1 99 11
2012-01-13protein level
1 100 11
2011-12-20protein level
1 100 11
2011-11-11protein level
1 98 11
2011-08-23protein level
1 98 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P60484-1
0 17 0 47136.0169
NX_P60484-2
10 17 0 64841.2134
NX_P60484-3
3 4 0 19783.7884
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-696162,EBI-349787 SLC9A3R1  
  .positive regulation of intrinsic apoptotic signaling pathway
.renal phosphate ion absorption
.negative regulation of ERK1 and ERK2 cascade
  + 21 more...
.growth factor receptor binding
.protein self-association
.beta-2 adrenergic receptor binding
  + 5 more...
.sperm midpiece
.cell periphery
.extracellular exosome
  + 15 more...
2 EBI-696162,EBI-743549 SPOP  
  .positive regulation of type B pancreatic cell apoptotic process
.positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin protein ligase binding .Cul3-RING ubiquitin ligase complex
.nuclear speck
.nucleoplasm
.nucleus
3 EBI-696162,EBI-311420 MAST3  
  .N/A .ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.N/A
4 EBI-696162,EBI-641237 PDGFRB  
  .positive regulation of DNA biosynthetic process
.positive regulation of reactive oxygen species metabolic process
.positive regulation of calcium ion import
  + 60 more...
.platelet-derived growth factor binding
.vascular endothelial growth factor binding
.protein kinase binding
  + 7 more...
.extracellular exosome
.lysosomal lumen
.intrinsic component of plasma membrane
  + 9 more...
5 EBI-696162,EBI-994813 CDC27  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 6 more...
.protein phosphatase binding .cytosol
.spindle
.centrosome
  + 4 more...
6 EBI-696162,EBI-2341576 BMI1  
  .positive regulation of ubiquitin-protein transferase activity
.positive regulation of fibroblast proliferation
.cellular protein metabolic process
  + 8 more...
.RING-like zinc finger domain binding
.zinc ion binding
.PRC1 complex
.PcG protein complex
.cytoplasm
  + 3 more...
7 EBI-696162,EBI-1383583 FRK  
  .innate immune response
.regulation of cell proliferation
.peptidyl-tyrosine autophosphorylation
  + 6 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
  + 2 more...
8 EBI-696162,EBI-726944 NEDD4  
  .negative regulation of sodium ion transmembrane transporter activity
.regulation of potassium ion transmembrane transporter activity
.protein K63-linked ubiquitination
  + 32 more...
.proline-rich region binding
.RNA polymerase binding
.ubiquitin protein ligase activity
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apicolateral plasma membrane
  + 8 more...
9 EBI-696162,EBI-357253 PPP1CA  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.cell division
.branching morphogenesis of an epithelial tube
  + 15 more...
.metal ion binding
.ribonucleoprotein complex binding
.phosphatase activity
.protein serine/threonine phosphatase activity
.PTW/PP1 phosphatase complex
.MLL5-L complex
.extracellular exosome
  + 10 more...
10 EBI-696162,EBI-353193 PRDX1  
  .hydrogen peroxide catabolic process
.regulation of NF-kappaB import into nucleus
.natural killer cell mediated cytotoxicity
  + 9 more...
.poly(A) RNA binding
.heme binding
.thioredoxin peroxidase activity
.peroxidase activity
.extracellular exosome
.melanosome
.cytosol
  + 7 more...
11 EBI-696162,EBI-1149760 SLC9A3R2  
  .negative regulation of phosphatidylinositol 3-kinase signaling
.protein complex assembly
.phosphatase binding
.protein C-terminus binding
.beta-catenin binding
.receptor binding
.extracellular exosome
.apical plasma membrane
.endomembrane system
  + 4 more...
12 EBI-696162,EBI-351394 DBN1  
  .neural precursor cell proliferation
.regulation of dendrite development
.regulation of neuronal synaptic plasticity
  + 4 more...
.profilin binding
.actin binding
.actomyosin
.dendrite
.actin cytoskeleton
  + 4 more...
13 EBI-696162,EBI-81196 NCOA3  
  .regulation of RNA biosynthetic process
.mammary gland branching involved in thelarche
.labyrinthine layer morphogenesis
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.thyroid hormone receptor binding
  + 7 more...
.extracellular exosome
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
bladder33
blood57
bone41
brain22
cervix123
connective tissue167
ear372
embryonic tissue23
eye67
heart89
intestine81
kidney52
larynx170
liver34
lung74
lymph22
lymph node479
mammary gland13
muscle37
ovary19
pancreas56
parathyroid291
pituitary gland60
placenta42
prostate84
skin33
spleen18
stomach156
testis32
thymus62
thyroid107
tonsil117
umbilical cord72
uterus43
vascular58
Health State
TissuesTPM*
normal61
adrenal tumor79
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma60
colorectal tumor115
gastrointestinal tumor143
germ cell tumor22
glioma46
head and neck tumor67
kidney tumor29
leukemia116
lung tumor38
lymphoma13
non-neoplasia10
ovarian tumor26
pancreatic tumor28
primitive neuroectodermal tumor of the CNS62
prostate cancer67
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor151
uterine tumor33
Developmental Stage
TissuesTPM*
adult72
embryoid body14
blastocyst16
neonate32
fetus122
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue30.7
adrenal gland18.5
appendix21.3
bone marrow17.9
cerebral cortex13.4
colon20
duodenum14.9
esophagus15.2
gallbladder18.5
heart muscle11.7
kidney15.1
liver17
lung13.9
lymph node22.2
ovary18.6
pancreas11
placenta24.7
prostate16.7
salivary gland11.7
skin12.4
small intestine16.6
spleen24.8
stomach16.3
testis26
thyroid gland16.9
urinary bladder17.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#137800, phenotype) Glioma susceptibility 1; GLM1OMIM
2(#153480, phenotype) Bannayan-riley-ruvalcaba syndrome; BRRSOMIM
3(#158350, phenotype) Cowden disease; CDOMIM
4(#176807, phenotype) Prostate cancerOMIM
5(#275355, phenotype) Squamous cell carcinoma, head and neck; HNSCCOMIM
6(#276950, phenotype) Vacterl association with hydrocephalusOMIM
7(+601728, gene/phenotype) Phosphatase and tensin homolog; PTENOMIM
8(#605309, phenotype) Macrocephaly/autism syndromeOMIM
9(#608089, phenotype) Endometrial cancerOMIM
10(#612242, phenotype) Chromosome 10q23 deletion syndromeOMIM
11(#613028, phenotype) Glioma susceptibility 2; GLM2OMIM
12glioma;prostate;endometrial;harmartoma;Cowden Syndrome;Bannayan-Riley-Ruvalcaba syndromeCGP


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