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> Protein (NX_P60520)
Protein (NX_P60520)
Protein
Gene SymbolGABARAPL2 to neXtProt (NX_P60520)
DescriptionGamma-aminobutyric acid receptor-associated protein-like 2
Chromosome16
Location16q23.1 (75600249 ~ 75611779) to Ensembl
Sequene Features : Isoforms 1, Variants 12, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 12 3
2014-09-19protein level
1 11 3
2014-05-27protein level
1 11 4
2014-02-25protein level
1 11 4
2013-12-09protein level
1 7 4
2013-11-01protein level
1 7 3
2013-09-12protein level
1 7 3
2013-08-17protein level
1 7 3
2013-07-15protein level
1 3 2
2013-06-11protein level
1 3 2
2013-02-12protein level
1 2 3
2012-12-20protein level
1 2 3
2012-10-30protein level
1 5 3
2012-10-07protein level
1 5 3
2012-08-24protein level
1 5 3
2012-07-28protein level
1 5 3
2012-06-08protein level
1 6 3
2012-05-07protein level
1 5 3
2012-04-10protein level
1 5 3
2012-01-13protein level
1 5 3
2011-12-20protein level
1 5 3
2011-11-11protein level
1 5 3
2011-08-23protein level
1 5 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P60520-1
6 0 0 13658.0293
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-720116,EBI-356424 IPO5  
  .cellular response to amino acid stimulus
.positive regulation of protein import into nucleus
.negative regulation of GTPase activity
  + 3 more...
.poly(A) RNA binding
.protein transporter activity
.Ran GTPase binding
.GTPase inhibitor activity
.intracellular membrane-bounded organelle
.nuclear membrane
.membrane
  + 6 more...
2 EBI-720116,EBI-2946991 TECPR2  
  .autophagy .N/A .N/A
3 EBI-720116,EBI-2798775 ATG13  
  .positive regulation of protein targeting to mitochondrion
.activation of mitophagy in response to mitochondrial depolarization
.autophagic vacuole assembly
.protein kinase binding .ULK1-ATG13-FIP200 complex
.ATG1/UKL1 signaling complex
.cytosol
  + 2 more...
4 EBI-720116,EBI-307133 GBAS  
  .negative regulation of ATP citrate synthase activity
.ATP biosynthetic process
.oxidative phosphorylation
.N/A .membrane
.integral component of plasma membrane
.mitochondrion
5 EBI-720116,EBI-908831 ULK1  
  .regulation of neurotrophin TRK receptor signaling pathway
.axon extension
.negative regulation of collateral sprouting
  + 15 more...
.protein complex binding
.Rab GTPase binding
.ATP binding
.protein serine/threonine kinase activity
.extrinsic component of autophagic vacuole membrane
.extrinsic component of pre-autophagosomal structure membrane
.extrinsic component of omegasome membrane
  + 9 more...
6 EBI-720116,EBI-2947137 STBD1  
  .muscle contraction .starch binding .membrane
.integral component of plasma membrane
7 EBI-720116,EBI-987834 ATG7  
  .negative regulation of histone H4-K16 acetylation
.regulation of mitochondrion degradation
.cellular response to hyperoxia
  + 33 more...
.protein homodimerization activity
.Atg8 activating enzyme activity
.Atg12 activating enzyme activity
  + 2 more...
.axoneme
.cytosol
.cytoplasm
.pre-autophagosomal structure
8 EBI-720116,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
9 EBI-720116,EBI-356720 HADHA  
  .glycerophospholipid biosynthetic process
.small molecule metabolic process
.cellular lipid metabolic process
  + 5 more...
.NAD binding
.long-chain-3-hydroxyacyl-CoA dehydrogenase activity
.long-chain-enoyl-CoA hydratase activity
  + 4 more...
.mitochondrial nucleoid
.mitochondrial fatty acid beta-oxidation multienzyme complex
.mitochondrial inner membrane
.mitochondrion
10 EBI-720116,EBI-726944 NEDD4  
  .negative regulation of sodium ion transmembrane transporter activity
.regulation of potassium ion transmembrane transporter activity
.protein K63-linked ubiquitination
  + 32 more...
.proline-rich region binding
.RNA polymerase binding
.ubiquitin protein ligase activity
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apicolateral plasma membrane
  + 8 more...
11 EBI-720116,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
12 EBI-720116,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
13 EBI-720116,EBI-367376 STK4  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.protein homodimerization activity
  + 6 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
14 EBI-720116,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
15 EBI-720116,EBI-992580 STK3  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.ATP binding
  + 4 more...
.cytosol
.cytoplasm
.nucleus
16 EBI-720116,EBI-307104 SQSTM1  
  .activation of mitophagy in response to mitochondrial depolarization
.apoptotic signaling pathway
.protein heterooligomerization
  + 20 more...
.ubiquitin binding
.identical protein binding
.SH2 domain binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.PML body
  + 11 more...
17 EBI-720116,EBI-356710 RCN2  
  .N/A .calcium ion binding .endoplasmic reticulum lumen
.endoplasmic reticulum
.nucleolus
18 EBI-720116,EBI-742698 NBR1  
  .protein oligomerization
.negative regulation of osteoblast differentiation
.regulation of stress-activated MAPK cascade
  + 2 more...
.mitogen-activated protein kinase binding
.ubiquitin binding
.zinc ion binding
.extracellular exosome
.M band
.cytoplasmic vesicle
  + 6 more...
19 EBI-720116,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
20 EBI-720116,EBI-2514077 ATG2A  
  .nucleophagy
.cellular response to nitrogen starvation
.mitochondrion degradation
.autophagic vacuole assembly
.N/A .pre-autophagosomal structure membrane
.extrinsic component of membrane
.lipid particle
.pre-autophagosomal structure
21 EBI-720116,EBI-10217736 TBC1D9B  
  .N/A .calcium ion binding
.GTPase activator activity
.integral component of membrane
22 EBI-720116,EBI-535909 ATG16L1  
  .protein homooligomerization
.negative stranded viral RNA replication
.protein transport
.autophagic vacuole assembly
.identical protein binding .pre-autophagosomal structure membrane
.axoneme
.autophagic vacuole
.autophagic vacuole membrane
23 EBI-720116,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
24 EBI-720116,EBI-2514778 KBTBD6  
  .N/A .N/A .N/A
25 EBI-720116,EBI-10217765 AHNAK2  
  .N/A .N/A .costamere
.sarcolemma
.cytoplasmic vesicle membrane
  + 5 more...
26 EBI-720116,EBI-3059266 FUNDC1  
  .response to hypoxia
.mitochondrion degradation
.N/A .integral component of mitochondrial outer membrane
.mitochondrial outer membrane
27 EBI-720116,EBI-1569256 WDFY3  
  .aggrephagy
.positive regulation of macroautophagy
.endosomal transport
.metal ion binding
.1-phosphatidylinositol binding
.beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
.extrinsic component of autophagic vacuole membrane
.nuclear membrane
.extrinsic component of membrane
  + 5 more...
28 EBI-720116,EBI-749265 CCDC155  
  .chromosome localization to nuclear envelope involved in homologous chromosome segregation
.oogenesis
.spermatogenesis
  + 2 more...
.N/A .integral component of membrane
.nuclear outer membrane
.lateral element
.chromosome, telomeric region
29 EBI-720116,EBI-716933 ARFGAP1  
  .membrane organization
.COPI coating of Golgi vesicle
.cellular protein metabolic process
  + 5 more...
.zinc ion binding
.GTPase activator activity
.synapse
.Golgi-associated vesicle membrane
.cytosol
30 EBI-720116,EBI-10181113 KIAA1958  
  .N/A .N/A .N/A
31 EBI-720116,EBI-1048247 TBC1D15  
  .positive regulation of GTPase activity
.regulation of GTPase activity
.GTPase activator activity .extracellular exosome
.mitochondrion
.cytoplasm
32 EBI-720116,EBI-1044009 NEK9  
  .cell division
.mitotic nuclear envelope disassembly
.mitotic nuclear division
  + 2 more...
.metal ion binding
.protein kinase binding
.ATP binding
.protein serine/threonine kinase activity
.cytosol
.nucleus
33 EBI-720116,EBI-473695 KBTBD7  
  .N/A .N/A .N/A
34 EBI-720116,EBI-367390 RASSF5  
  .regulation of protein localization to nucleus
.intracellular signal transduction
.positive regulation of protein ubiquitination
  + 2 more...
.metal ion binding .microtubule
.cytoplasm
.nucleus
35 EBI-720116,EBI-2946907 DYX1C1  
  .regulation of proteasomal protein catabolic process
.inner dynein arm assembly
.outer dynein arm assembly
  + 4 more...
.estrogen receptor binding .plasma membrane
.cytoplasm
.nucleus
36 EBI-720116,EBI-746981 TSR2  
  .maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) .N/A .nucleus
37 EBI-720116,EBI-2869338 FYCO1  
  .plus-end-directed vesicle transport along microtubule .metal ion binding .cytoplasmic vesicle
.integral component of membrane
.membrane
  + 3 more...
38 EBI-720116,EBI-747430 BCL2L13  
  .activation of cysteine-type endopeptidase activity involved in apoptotic process
.apoptotic process
.cysteine-type endopeptidase activator activity involved in apoptotic process .mitochondrial membrane
.integral component of membrane
.mitochondrion
.nucleus
39 EBI-720116,EBI-747805 UBA5  
  .protein polyufmylation
.protein ufmylation
.response to endoplasmic reticulum stress
.regulation of intracellular estrogen receptor signaling pathway
.UFM1 activating enzyme activity
.metal ion binding
.ATP binding
.intracellular membrane-bounded organelle
.cytosol
.cytoplasm
.nucleus
40 EBI-720116,EBI-1181664 SIK2  
  .protein autophosphorylation
.regulation of insulin receptor signaling pathway
.intracellular signal transduction
  + 3 more...
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytoplasm
.nucleus
41 EBI-720116,EBI-367363 RASSF1  
  .negative regulation of cell cycle arrest
.protein stabilization
.positive regulation of protein ubiquitination
  + 3 more...
.protein N-terminus binding
.identical protein binding
.zinc ion binding
.microtubule cytoskeleton
.plasma membrane
.microtubule
  + 4 more...
42 EBI-720116,EBI-988094 ATG3  
  .regulation of cilium assembly
.nucleophagy
.mitochondrial fragmentation involved in apoptotic process
  + 5 more...
.enzyme binding
.ubiquitin-like protein transferase activity
.Atg12 transferase activity
  + 2 more...
.cytosol
.cytoplasmic ubiquitin ligase complex
43 EBI-720116,EBI-749920 CALCOCO1  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.armadillo repeat domain binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 6 more...
.intracellular membrane-bounded organelle
.cytoplasm
.nucleus
.nuclear chromatin
44 EBI-720116,EBI-2513908 ANKFY1  
  .Golgi to lysosome transport
.positive regulation of pinocytosis
.retrograde transport, endosome to Golgi
  + 3 more...
.phosphatidylinositol phosphate binding
.metal ion binding
.Rab GTPase binding
.extracellular exosome
.macropinosome
.membrane
  + 3 more...
45 EBI-720116,EBI-741109 MLX  
  .negative regulation of transcription, DNA-templated
.small molecule metabolic process
.positive regulation of cellular metabolic process
  + 4 more...
.protein heterodimerization activity
.protein homodimerization activity
.transcription factor binding
  + 4 more...
.cytoplasm
.nucleus
46 EBI-720116,EBI-2947180 TBC1D2B  
  .N/A .GTPase activator activity .N/A
47 EBI-720116,EBI-712014 ATG4B  
  .protein delipidation
.positive regulation of protein catabolic process
.nucleophagy
  + 9 more...
.cysteine-type peptidase activity
.cysteine-type endopeptidase activity
.endopeptidase activity
.cytosol
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites25
bladder167
blood253
bone83
bone marrow41
brain217
connective tissue20
embryonic tissue23
eye119
heart22
intestine43
kidney28
liver24
lung47
lymph67
lymph node77
mammary gland26
mouth45
muscle47
nerve193
ovary59
pancreas117
pharynx98
pituitary gland363
placenta63
prostate47
salivary gland49
skin33
stomach62
testis105
thymus12
thyroid64
umbilical cord72
uterus47
Health State
TissuesTPM*
normal86
bladder carcinoma170
breast (mammary gland) tumor10
chondrosarcoma60
colorectal tumor26
gastrointestinal tumor50
germ cell tumor30
glioma55
head and neck tumor37
kidney tumor14
leukemia42
liver tumor41
lung tumor19
lymphoma83
non-neoplasia51
ovarian tumor65
pancreatic tumor66
primitive neuroectodermal tumor of the CNS23
prostate cancer77
retinoblastoma107
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult56
embryoid body28
neonate32
fetus44
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue86.8
adrenal gland154.6
appendix68.2
bone marrow61.2
cerebral cortex169.1
colon86.3
duodenum58.2
esophagus75.3
gallbladder89.9
heart muscle203.6
kidney114.5
liver57.8
lung84.9
lymph node88.7
ovary87.9
pancreas33.3
placenta95.4
prostate112.4
salivary gland72.5
skin71.8
small intestine62.4
spleen84
stomach73
testis75.1
thyroid gland116.7
urinary bladder88.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607452, gene) Gaba-a receptor-associated protein-like protein 2; GABARAPL2OMIM


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