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> Protein (NX_P60900)
Protein (NX_P60900)
Protein
Gene SymbolPSMA6 to neXtProt (NX_P60900)
DescriptionProteasome subunit alpha type-6
Chromosome14
Location14q13.2 (35747839 ~ 35786699) to Ensembl
Sequene Features : Isoforms 3, Variants 27, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.proteolysis involved in cellular protein catabolic process
  + 26 more...
.NF-kappaB binding
.purine ribonucleoside triphosphate binding
.threonine-type endopeptidase activity
  + 2 more...
.extracellular exosome
.sarcomere
.myofibril
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 27 16
2014-09-19protein level
3 17 16
2014-05-27protein level
3 17 16
2014-02-25protein level
1 15 16
2013-12-09protein level
1 15 16
2013-11-01protein level
1 14 16
2013-09-12protein level
1 14 16
2013-08-17protein level
1 14 16
2013-07-15protein level
1 11 7
2013-06-11protein level
1 11 7
2013-02-12protein level
1 2 7
2012-12-20protein level
1 2 7
2012-10-30protein level
1 2 7
2012-10-07protein level
1 2 6
2012-08-24protein level
1 2 6
2012-07-28protein level
1 2 6
2012-06-08protein level
1 3 6
2012-05-07protein level
1 3 6
2012-04-10protein level
1 3 6
2012-01-13protein level
1 4 6
2011-12-20protein level
1 4 6
2011-11-11protein level
1 4 5
2011-08-23protein level
1 4 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P60900-1
3 10 0 27381.7319
NX_P60900-2
0 10 0 25273.7413
NX_P60900-3
1 6 0 18803.2847
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-357793,EBI-603272 PSMA7  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.identical protein binding
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
2 EBI-357793,EBI-603262 PSMA2  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 24 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 6 more...
3 EBI-357793,EBI-348380 PSMA3  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
4 EBI-357793,EBI-359310 PSMA4  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.intracellular membrane-bounded organelle
.proteasome core complex, alpha-subunit complex
  + 8 more...
5 EBI-357793,EBI-741210 C19orf57  
  .multicellular organismal development .N/A .N/A
6 EBI-357793,EBI-10217913 RTP5  
  .N/A .N/A .integral component of membrane
7 EBI-357793,EBI-5658292 ZBTB44  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
8 EBI-357793,EBI-2130336 RNF170  
  .protein ubiquitination .ligase activity
.zinc ion binding
.integral component of membrane
.endoplasmic reticulum membrane
9 EBI-357793,EBI-2805292 LIMD2  
  .N/A .zinc ion binding .N/A
10 EBI-357793,EBI-5652260 CADM1  
  .bone development
.detection of stimulus
.positive regulation of cytokine secretion
  + 17 more...
.protein homodimerization activity
.PDZ domain binding
.receptor binding
.extracellular exosome
.dendrite
.axon
  + 5 more...
11 EBI-357793,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
12 EBI-357793,EBI-739510 TRIM39  
  .positive regulation of apoptotic signaling pathway
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.protein ubiquitination
.apoptotic process
.identical protein binding
.ligase activity
.zinc ion binding
.cytosol
.mitochondrion
13 EBI-357793,EBI-1051183 UCHL5  
  .regulation of proteasomal protein catabolic process
.forebrain morphogenesis
.midbrain development
  + 10 more...
.proteasome binding
.poly(A) RNA binding
.omega peptidase activity
  + 2 more...
.Ino80 complex
.cytosol
.nucleus
.proteasome complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland151
ascites401
bladder636
blood310
bone195
bone marrow184
brain70
cervix61
connective tissue181
embryonic tissue98
esophagus49
eye153
heart234
intestine133
kidney99
larynx85
liver165
lung292
lymph135
lymph node44
mammary gland158
mouth15
muscle178
ovary98
pancreas70
parathyroid1845
pharynx220
pituitary gland181
placenta109
prostate342
salivary gland345
skin241
spleen37
stomach125
testis204
thymus62
thyroid42
umbilical cord145
uterus120
vascular96
Health State
TissuesTPM*
normal124
adrenal tumor237
bladder carcinoma1080
breast (mammary gland) tumor161
cervical tumor86
chondrosarcoma253
colorectal tumor151
esophageal tumor57
gastrointestinal tumor168
germ cell tumor170
glioma242
head and neck tumor37
kidney tumor130
leukemia116
liver tumor218
lung tumor175
lymphoma138
non-neoplasia41
ovarian tumor131
pancreatic tumor47
primitive neuroectodermal tumor of the CNS110
prostate cancer491
retinoblastoma150
skin tumor135
soft tissue/muscle tissue tumor231
uterine tumor99
Developmental Stage
TissuesTPM*
adult172
embryoid body157
blastocyst65
neonate64
fetus140
infant85
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue36.4
adrenal gland35.7
appendix41.7
bone marrow43
cerebral cortex24.9
colon44.3
duodenum36.8
esophagus35.3
gallbladder25.9
heart muscle36.7
kidney28.9
liver24.9
lung31.1
lymph node41.6
ovary23.6
pancreas12.9
placenta38
prostate27.3
salivary gland21
skin25.7
small intestine36.1
spleen26.4
stomach30.6
testis63.1
thyroid gland27.1
urinary bladder38.6
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
breastHigh
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineLow
colonLow
duodenumMedium
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverHigh
lungHigh
lymph nodeLow
nasopharynxMedium
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilLow
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602855, gene) Proteasome subunit, alpha-type, 6; PSMA6OMIM


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