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> Protein (NX_P60953)
Protein (NX_P60953)
Protein
Gene SymbolCDC42 to neXtProt (NX_P60953)
DescriptionCell division control protein 42 homolog
Chromosome1
Location1p36.12 (22379120 ~ 22419437) to Ensembl
Sequene Features : Isoforms 2, Variants 19, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of substrate adhesion-dependent cell spreading
.positive regulation of intracellular protein transport
.epithelial cell-cell adhesion
  + 61 more...
.identical protein binding
.apolipoprotein A-I receptor binding
.thioesterase binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.spindle midzone
  + 17 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 19 12
2014-09-19protein level
2 13 12
2014-05-27protein level
2 13 13
2014-02-25protein level
2 13 13
2013-12-09protein level
2 13 13
2013-11-01protein level
2 13 9
2013-09-12protein level
2 13 9
2013-08-17protein level
2 13 9
2013-07-15protein level
2 9 6
2013-06-11protein level
2 9 6
2013-02-12protein level
2 2 13
2012-12-20protein level
2 2 13
2012-10-30protein level
2 2 11
2012-10-07protein level
2 2 7
2012-08-24protein level
2 1 7
2012-07-28protein level
2 1 7
2012-06-08protein level
2 5 7
2012-05-07protein level
2 5 7
2012-04-10protein level
2 5 7
2012-01-13protein level
2 4 7
2011-12-20protein level
2 5 7
2011-11-11protein level
2 5 7
2011-08-23protein level
2 5 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P60953-1
2 7 1 21296.8618
NX_P60953-2
2 7 1 21244.9572
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-81752,EBI-957615 WASL  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of lymphocyte migration
.positive regulation of clathrin-mediated endocytosis
  + 24 more...
.GTPase regulator activity .extracellular exosome
.endocytic vesicle membrane
.actin cap
  + 6 more...
2 EBI-81752,EBI-3438291 CDC42EP2  
  .positive regulation of GTPase activity
.positive regulation of protein complex assembly
.positive regulation of pseudopodium assembly
  + 4 more...
.GTP-Rho binding
.GTPase activator activity
.membrane
.microtubule cytoskeleton
.endomembrane system
  + 2 more...
3 EBI-287394,EBI-3389553 PAK3  
  .positive regulation of DNA biosynthetic process
.positive regulation of dendritic spine morphogenesis
.dendritic spine morphogenesis
  + 21 more...
.Rac GTPase binding
.metal ion binding
.ATP binding
  + 2 more...
.plasma membrane
.cytosol
.endosome
.cytoplasm
4 EBI-81752,EBI-784112 ABCA1  
  .anion transmembrane transport
.cellular response to cholesterol
.cellular response to retinoic acid
  + 32 more...
.ATPase binding
.ATPase activity, coupled to transmembrane movement of substances
.apolipoprotein A-I receptor activity
  + 11 more...
.perinuclear region of cytoplasm
.phagocytic vesicle
.membrane raft
  + 6 more...
5 EBI-81752,EBI-713738 PAK4  
  .regulation of MAPK cascade
.regulation of apoptotic process
.activation of protein kinase activity
  + 12 more...
.Rac GTPase binding
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.focal adhesion
.Golgi apparatus
6 EBI-81752,EBI-286199 PRKCI  
  .positive regulation of endothelial cell apoptotic process
.positive regulation of establishment of protein localization to plasma membrane
.tight junction assembly
  + 25 more...
.metal ion binding
.phospholipid binding
.ATP binding
  + 3 more...
.extracellular exosome
.intercellular bridge
.protein complex
  + 11 more...
7 EBI-81752,EBI-346375 WAS  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of cell motility
.T cell receptor signaling pathway
  + 15 more...
.phospholipase binding
.identical protein binding
.GTPase regulator activity
  + 2 more...
.extracellular exosome
.actin cytoskeleton
.vesicle membrane
  + 2 more...
8 EBI-81752,EBI-286483 MAPK8  
  .positive regulation of determination of dorsal identity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.programmed necrotic cell death
  + 45 more...
.histone deacetylase binding
.histone deacetylase regulator activity
.enzyme binding
  + 3 more...
.cytosol
.mitochondrion
.nucleoplasm
.nucleus
9 EBI-81752,EBI-297509 IQGAP1  
  .neuron projection extension
.glomerular visceral epithelial cell development
.positive regulation of protein serine/threonine kinase activity
  + 16 more...
.protein serine/threonine kinase activator activity
.protein phosphatase binding
.protein kinase binding
  + 5 more...
.extracellular exosome
.neuron projection
.cytoplasmic ribonucleoprotein granule
  + 15 more...
10 EBI-81752,EBI-744130 CDC42EP1  
  .positive regulation of pseudopodium assembly
.positive regulation of actin filament polymerization
.regulation of cell shape
.Rho protein signal transduction
.GTP-Rho binding .actin cytoskeleton
.focal adhesion
.plasma membrane
  + 2 more...
11 EBI-287394,EBI-603457 TNK2  
  .regulation of clathrin-mediated endocytosis
.positive regulation of peptidyl-tyrosine phosphorylation
.innate immune response
  + 10 more...
.hormone receptor binding
.WW domain binding
.metal ion binding
  + 8 more...
.Grb2-EGFR complex
.neuronal cell body
.extrinsic component of cytoplasmic side of plasma membrane
  + 12 more...
12 EBI-81752,EBI-602762 ARHGAP1  
  .regulation of small GTPase mediated signal transduction
.positive regulation of GTPase activity
.regulation of GTPase activity
  + 3 more...
.GTPase activator activity
.SH3/SH2 adaptor activity
.extracellular exosome
.plasma membrane
.cytosol
  + 2 more...
13 EBI-81752,EBI-1307 PAK1  
  .negative regulation of cell proliferation involved in contact inhibition
.positive regulation of stress fiber assembly
.T cell receptor signaling pathway
  + 32 more...
.Rac GTPase binding
.ATP binding
.collagen binding
  + 2 more...
.protein complex
.ruffle membrane
.nuclear membrane
  + 12 more...
14 EBI-81752,EBI-1045887 PAK2  
  .negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
.positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of protein tyrosine kinase activity
  + 30 more...
.Rac GTPase binding
.identical protein binding
.protein tyrosine kinase activator activity
  + 4 more...
.perinuclear region of cytoplasm
.plasma membrane
.cytosol
  + 2 more...
15 EBI-3625591,EBI-602041 ITSN1  
  .apoptotic signaling pathway
.positive regulation of protein kinase B signaling
.regulation of small GTPase mediated signal transduction
  + 8 more...
.proline-rich region binding
.protein complex scaffold
.kinase activator activity
  + 3 more...
.synapse
.neuron projection
.endocytic vesicle
  + 5 more...
16 EBI-81752,EBI-49961 MAP3K11  
  .protein autophosphorylation
.positive regulation of JNK cascade
.positive regulation of neuron apoptotic process
  + 8 more...
.protein homodimerization activity
.identical protein binding
.mitogen-activated protein kinase kinase kinase binding
  + 5 more...
.membrane
.microtubule
.centrosome
.cytoplasm
17 EBI-81752,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
18 EBI-81752,EBI-689171 CDC42BPA  
  .intracellular signal transduction
.actin cytoskeleton reorganization
.actomyosin structure organization
  + 4 more...
.identical protein binding
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.extracellular exosome
.actomyosin
.cell leading edge
  + 2 more...
19 EBI-81752,EBI-302319 MARK4  
  .positive regulation of programmed cell death
.nervous system development
.organelle organization
  + 3 more...
.tau-protein kinase activity
.ubiquitin binding
.gamma-tubulin binding
  + 3 more...
.neuron projection
.ciliary basal body
.microtubule cytoskeleton
  + 3 more...
20 EBI-81752,EBI-295417 PARD6G  
  .tight junction assembly
.cell division
.cell-cell junction organization
  + 2 more...
.N/A .protein complex
.tight junction
.plasma membrane
.cytosol
21 EBI-81752,EBI-295391 PARD6B  
  .tight junction assembly
.cell division
.cell-cell junction organization
  + 7 more...
.N/A .extracellular exosome
.apical part of cell
.protein complex
  + 6 more...
22 EBI-81752,EBI-81876 PARD6A  
  .tight junction assembly
.cell division
.cell-cell junction maintenance
  + 5 more...
.GTP-dependent protein binding
.Rho GTPase binding
.transcription factor binding
.apical part of cell
.protein complex
.cell cortex
  + 5 more...
23 EBI-287394,EBI-525456 BAIAP2  
  .positive regulation of actin cytoskeleton reorganization
.actin crosslink formation
.actin filament bundle assembly
  + 13 more...
.proline-rich region binding
.identical protein binding
.cytoskeletal adaptor activity
.protein C-terminus binding
.extracellular exosome
.neuron projection
.filopodium
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland60
ascites527
bladder435
blood523
bone167
bone marrow328
brain224
cervix247
connective tissue221
ear248
embryonic tissue108
esophagus396
eye95
heart368
intestine155
kidney298
larynx42
liver102
lung226
lymph node144
mammary gland231
mouth105
muscle112
nerve257
ovary78
pancreas238
parathyroid534
pharynx171
pituitary gland60
placenta102
prostate184
salivary gland49
skin241
spleen318
stomach146
testis121
thymus175
thyroid64
trachea193
umbilical cord145
uterus461
vascular677
Health State
TissuesTPM*
normal239
adrenal tumor79
bladder carcinoma284
breast (mammary gland) tumor290
cervical tumor173
chondrosarcoma193
colorectal tumor71
esophageal tumor463
gastrointestinal tumor303
germ cell tumor224
glioma102
head and neck tumor59
kidney tumor275
leukemia243
liver tumor156
lung tumor175
lymphoma13
non-neoplasia196
ovarian tumor65
pancreatic tumor219
primitive neuroectodermal tumor of the CNS165
prostate cancer125
retinoblastoma86
skin tumor87
soft tissue/muscle tissue tumor143
uterine tumor199
Developmental Stage
TissuesTPM*
adult177
embryoid body142
blastocyst32
neonate418
fetus271
infant85
juvenile359
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue82.1
adrenal gland72.8
appendix97
bone marrow132.7
cerebral cortex70
colon109.4
duodenum77
esophagus81.3
gallbladder73.9
heart muscle49.8
kidney75.1
liver53.4
lung85.5
lymph node91.5
ovary55.1
pancreas24.1
placenta89.5
prostate63.1
salivary gland43.5
skin59.5
small intestine85.9
spleen81.6
stomach82.4
testis40.9
thyroid gland60.6
urinary bladder90.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleHigh
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*116952, gene) Cell division cycle 42; CDC42OMIM


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