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> Protein (NX_P60981)
Protein (NX_P60981)
Protein
Gene SymbolDSTN to neXtProt (NX_P60981)
DescriptionDestrin
Chromosome20
Location20p12.1 (17550508 ~ 17590564) to Ensembl
Sequene Features : Isoforms 2, Variants 16, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.actin filament severing
.positive regulation of actin filament depolymerization
.actin filament depolymerization
.actin polymerization or depolymerization
.N/A .extracellular exosome
.cortical actin cytoskeleton
.actin cytoskeleton
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 16 9
2014-09-19protein level
2 14 9
2014-05-27protein level
2 14 11
2014-02-25protein level
2 14 11
2013-12-09protein level
2 13 11
2013-11-01protein level
2 13 8
2013-09-12protein level
2 13 8
2013-08-17protein level
2 13 8
2013-07-15protein level
2 9 6
2013-06-11protein level
2 9 6
2013-02-12protein level
2 3 8
2012-12-20protein level
2 3 8
2012-10-30protein level
2 4 8
2012-10-07protein level
2 4 5
2012-08-24protein level
2 4 5
2012-07-28protein level
2 4 5
2012-06-08protein level
2 4 5
2012-05-07protein level
2 2 5
2012-04-10protein level
2 2 5
2012-01-13protein level
1 2 5
2011-12-20protein level
1 2 5
2011-11-11protein level
1 2 4
2011-08-23protein level
1 2 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P60981-1
1 9 0 18493.4239
NX_P60981-2
0 9 0 16609.5743
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-745191,EBI-353944 ACTB  
  .platelet aggregation
.membrane organization
.'de novo' posttranslational protein folding
  + 17 more...
.nitric-oxide synthase binding
.identical protein binding
.Tat protein binding
  + 3 more...
.blood microparticle
.MLL5-L complex
.extracellular exosome
  + 16 more...
2 EBI-745191,EBI-351292 ACTG1  
  .platelet aggregation
.membrane organization
.ephrin receptor signaling pathway
  + 11 more...
.identical protein binding
.ubiquitin protein ligase binding
.ATP binding
.structural constituent of cytoskeleton
.blood microparticle
.extracellular exosome
.filamentous actin
  + 7 more...
3 EBI-745191,EBI-529518 TAX1BP1  
  .innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland242
ascites50
bladder167
bone27
bone marrow20
brain9
cervix185
connective tissue20
embryonic tissue14
esophagus595
eye9
heart55
intestine30
kidney28
larynx127
liver19
lung17
lymph45
lymph node77
mammary gland59
mouth30
muscle56
nerve386
ovary29
pancreas9
parathyroid194
pharynx24
pituitary gland121
placenta24
prostate163
salivary gland148
skin14
spleen18
stomach41
testis6
thyroid150
trachea57
umbilical cord653
uterus94
vascular19
Health State
TissuesTPM*
normal18
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor53
cervical tumor115
chondrosarcoma12
colorectal tumor44
esophageal tumor231
gastrointestinal tumor50
germ cell tumor3
glioma18
head and neck tumor82
kidney tumor14
leukemia74
liver tumor41
lung tumor155
lymphoma83
non-neoplasia113
ovarian tumor26
pancreatic tumor123
primitive neuroectodermal tumor of the CNS7
prostate cancer221
retinoblastoma150
skin tumor151
soft tissue/muscle tissue tumor15
uterine tumor99
Developmental Stage
TissuesTPM*
adult53
embryoid body14
blastocyst16
neonate289
fetus30
infant340
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue254.2
adrenal gland259.5
appendix161
bone marrow43.9
cerebral cortex165.9
colon355.9
duodenum155.9
esophagus572.2
gallbladder370.8
heart muscle383.1
kidney236
liver93.2
lung306.7
lymph node73.3
ovary219.8
pancreas178.6
placenta178.5
prostate566.2
salivary gland268.1
skin158.6
small intestine189.5
spleen82.7
stomach185.2
testis111.9
thyroid gland308.2
urinary bladder519
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleLow
kidneyHigh
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleHigh
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609114, gene) Destrin; DSTNOMIM


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