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> Protein (NX_P61006)
Protein (NX_P61006)
Protein
Gene SymbolRAB8A to neXtProt (NX_P61006)
DescriptionRas-related protein Rab-8A
Chromosome19
Location19p13.12 (16222439 ~ 16245044) to Ensembl
Sequene Features : Isoforms 2, Variants 26, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein localization to plasma membrane
.membrane organization
.regulation of protein transport
  + 15 more...
.myosin V binding
.GDP binding
.Rab GTPase binding
  + 2 more...
.primary cilium
.extracellular exosome
.recycling endosome membrane
  + 19 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 26 6
2014-09-19protein level
1 17 6
2014-05-27protein level
1 17 6
2014-02-25protein level
1 17 6
2013-12-09protein level
1 15 6
2013-11-01protein level
1 14 6
2013-09-12protein level
1 14 6
2013-08-17protein level
1 14 6
2013-07-15protein level
1 6 6
2013-06-11protein level
1 6 6
2013-02-12protein level
1 2 5
2012-12-20protein level
1 2 5
2012-10-30protein level
1 2 5
2012-10-07protein level
1 2 5
2012-08-24protein level
1 1 5
2012-07-28protein level
1 1 5
2012-06-08protein level
1 2 5
2012-05-07protein level
1 5 5
2012-04-10protein level
1 5 5
2012-01-13protein level
1 1 5
2011-12-20protein level
1 1 5
2011-11-11protein level
1 1 5
2011-08-23protein level
1 1 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P61006-1
2 3 4 23653.1209
NX_P61006-2
2 3 4 23548.8518
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-722293,EBI-713992 RABIF  
  .membrane fusion
.positive regulation of GTPase activity
.protein transport
.small GTPase mediated signal transduction
.zinc ion binding
.guanyl-nucleotide exchange factor activity
.N/A
2 EBI-722293,EBI-6148898 OCRL  
  .regulation of small GTPase mediated signal transduction
.phosphatidylinositol dephosphorylation
.small molecule metabolic process
  + 9 more...
.inositol phosphate phosphatase activity
.Rac GTPase binding
.GTPase activator activity
.phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
.extracellular exosome
.early endosome membrane
.phagocytic vesicle membrane
  + 11 more...
3 EBI-722293,EBI-748974 OPTN  
  .Golgi ribbon formation
.defense response to Gram-negative bacterium
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 10 more...
.K63-linked polyubiquitin binding
.identical protein binding
.polyubiquitin binding
  + 2 more...
.recycling endosome
.perinuclear region of cytoplasm
.cytoplasmic membrane-bounded vesicle
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites75
bladder167
blood130
bone139
bone marrow123
brain69
cervix206
connective tissue67
embryonic tissue93
esophagus248
eye52
heart22
intestine133
kidney90
liver112
lung158
lymph248
lymph node55
mammary gland72
mouth60
muscle65
nerve128
ovary98
pancreas89
pharynx73
pituitary gland121
placenta102
prostate105
salivary gland148
skin227
spleen168
stomach146
testis112
thymus75
thyroid42
tonsil176
trachea19
uterus107
vascular135
Health State
TissuesTPM*
normal76
adrenal tumor158
breast (mammary gland) tumor64
cervical tumor260
chondrosarcoma108
colorectal tumor97
esophageal tumor289
gastrointestinal tumor75
germ cell tumor106
glioma93
head and neck tumor74
kidney tumor116
leukemia84
liver tumor166
lung tumor262
lymphoma249
non-neoplasia72
ovarian tumor131
pancreatic tumor133
primitive neuroectodermal tumor of the CNS212
prostate cancer125
retinoblastoma86
skin tumor327
soft tissue/muscle tissue tumor95
uterine tumor177
Developmental Stage
TissuesTPM*
adult74
embryoid body71
blastocyst130
neonate96
fetus43
infant85
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24
adrenal gland24
appendix45.2
bone marrow32.4
cerebral cortex17.1
colon47.1
duodenum51.1
esophagus17.3
gallbladder20.3
heart muscle8.4
kidney30.1
liver48.4
lung28.9
lymph node37.7
ovary21.6
pancreas10.3
placenta25.6
prostate25.6
salivary gland19.8
skin16.7
small intestine55.3
spleen39.6
stomach35.5
testis18.1
thyroid gland15
urinary bladder24.4
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*165040, gene) Ras-associated protein rab8a; RAB8AOMIM


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