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> Protein (NX_P61024)
Protein (NX_P61024)
Protein
Gene SymbolCKS1B to neXtProt (NX_P61024)
DescriptionCyclin-dependent kinases regulatory subunit 1
Chromosome1
Location1q21.3 (154947129 ~ 154951725) to Ensembl
Sequene Features : Isoforms 1, Variants 4, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell division
.cell proliferation
.mitotic cell cycle
  + 2 more...
.cyclin-dependent protein serine/threonine kinase regulator activity .nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 4 2
2014-09-19protein level
1 4 2
2014-05-27protein level
1 4 2
2014-02-25protein level
1 4 2
2013-12-09protein level
1 4 3
2013-11-01protein level
1 4 2
2013-09-12protein level
1 4 1
2013-08-17protein level
1 4 1
2013-07-15protein level
1 3 0
2013-06-11protein level
1 3 0
2013-02-12protein level
1 2 0
2012-12-20protein level
1 2 0
2012-10-30protein level
1 2 0
2012-10-07protein level
1 2 0
2012-08-24protein level
1 2 0
2012-07-28protein level
1 2 0
2012-06-08protein level
1 2 0
2012-05-07protein level
1 1 0
2012-04-10protein level
1 1 0
2012-01-13protein level
1 0 0
2011-12-20protein level
1 0 0
2011-11-11protein level
1 0 0
2011-08-23protein level
1 0 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P61024-1
3 0 0 9653.9086
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-456371,EBI-10181162 CDX4  
  .labyrinthine layer development
.positive regulation of transcription from RNA polymerase II promoter
.anterior/posterior pattern specification
  + 2 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
2 EBI-456371,EBI-444308 CDK1  
  .cellular response to hydrogen peroxide
.positive regulation of cardiac muscle cell proliferation
.ventricular cardiac muscle cell development
  + 69 more...
.histone kinase activity
.RNA polymerase II carboxy-terminal domain kinase activity
.ATP binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.midbody
  + 8 more...
3 EBI-456371,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
4 EBI-456371,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
5 EBI-456371,EBI-375096 CDK2  
  .cellular response to nitric oxide
.regulation of gene silencing
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 20 more...
.metal ion binding
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.Cajal body
.cytosol
.centrosome
  + 10 more...
6 EBI-456371,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
7 EBI-456371,EBI-2864512 MEOX1  
  .sclerotome development
.somite development
.hematopoietic stem cell differentiation
  + 2 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 3 more...
.cytoplasm
.nucleus
8 EBI-456371,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
9 EBI-456371,EBI-517127 XIAP  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.positive regulation of protein linear polyubiquitination
.intrinsic apoptotic signaling pathway
  + 15 more...
.ubiquitin protein ligase activity
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 2 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
10 EBI-456371,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
11 EBI-456371,EBI-456291 SKP2  
  .cellular response to cell-matrix adhesion
.regulation of cell cycle
.positive regulation of smooth muscle cell proliferation
  + 8 more...
.identical protein binding
.ubiquitin-protein transferase activity
.SCF ubiquitin ligase complex
.aggresome
.cytosol
  + 4 more...
12 EBI-456371,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
13 EBI-456371,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
14 EBI-456371,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
15 EBI-456371,EBI-1378139 ROPN1  
  .small GTPase mediated signal transduction .N/A .cytoplasm
.nucleus
16 EBI-456371,EBI-727037 SEPT3  
  .cell division
.cell cycle
.GTP binding .synapse
.cell junction
.cytoskeleton
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland182
ascites326
bladder100
blood32
bone139
bone marrow20
brain34
cervix82
connective tissue33
ear124
embryonic tissue122
eye67
heart55
intestine81
kidney37
liver219
lung95
lymph225
lymph node11
mammary gland138
mouth45
muscle65
ovary118
pancreas74
parathyroid291
pharynx49
pituitary gland60
placenta63
prostate73
salivary gland148
skin104
spleen37
stomach94
testis55
thymus37
umbilical cord72
uterus56
vascular19
Health State
TissuesTPM*
normal62
adrenal tumor474
bladder carcinoma170
breast (mammary gland) tumor150
cervical tumor115
chondrosarcoma144
colorectal tumor35
gastrointestinal tumor160
germ cell tumor113
glioma121
head and neck tumor22
kidney tumor14
leukemia74
liver tumor208
lung tumor97
lymphoma263
non-neoplasia10
ovarian tumor144
pancreatic tumor133
primitive neuroectodermal tumor of the CNS118
prostate cancer96
retinoblastoma193
skin tumor55
soft tissue/muscle tissue tumor95
uterine tumor33
Developmental Stage
TissuesTPM*
adult70
embryoid body128
blastocyst113
neonate64
fetus95
infant127
juvenile233
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.6
adrenal gland16
appendix14.1
bone marrow29.7
cerebral cortex5.2
colon19.2
duodenum14.9
esophagus14.5
gallbladder8.8
heart muscle7.7
kidney10.9
liver15.9
lung9.3
lymph node25.9
ovary12.2
pancreas3.4
placenta20.9
prostate8.5
salivary gland6.6
skin15.2
small intestine17
spleen10.7
stomach12.8
testis18.6
thyroid gland11.8
urinary bladder12.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*116900, gene) Cdc28 protein kinase 1b; CKS1BOMIM


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