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> Protein (NX_P61086)
Protein (NX_P61086)
Protein
Gene SymbolUBE2K to neXtProt (NX_P61086)
DescriptionUbiquitin-conjugating enzyme E2 K
Chromosome4
Location4p14 (39699664 ~ 39784412) to Ensembl
Sequene Features : Isoforms 3, Variants 18, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein K48-linked ubiquitination
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin protein ligase activity
.ubiquitin-ubiquitin ligase activity
.ubiquitin protein ligase binding
  + 4 more...
.extracellular exosome
.intermediate filament cytoskeleton
.actin cytoskeleton
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 18 5
2014-09-19protein level
3 14 5
2014-05-27protein level
3 14 6
2014-02-25protein level
3 14 6
2013-12-09protein level
3 13 6
2013-11-01protein level
3 13 5
2013-09-12protein level
3 13 5
2013-08-17protein level
3 13 5
2013-07-15protein level
3 5 4
2013-06-11protein level
3 5 4
2013-02-12protein level
2 0 8
2012-12-20protein level
2 0 8
2012-10-30protein level
2 0 8
2012-10-07protein level
2 0 4
2012-08-24protein level
2 0 4
2012-07-28protein level
2 0 4
2012-06-08protein level
2 1 4
2012-05-07protein level
2 2 4
2012-04-10protein level
2 2 4
2012-01-13protein level
2 2 4
2011-12-20protein level
2 2 4
2011-11-11protein level
2 2 3
2011-08-23protein level
2 2 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P61086-1
0 11 0 22392.5023
NX_P61086-2
0 8 0 16607.5869
NX_P61086-3
1 7 0 17436.0858
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-473850,EBI-495332 CCNB1  
  .histone H3-S10 phosphorylation involved in chromosome condensation
.regulation of mitotic cell cycle spindle assembly checkpoint
.cellular response to hypoxia
  + 33 more...
.histone kinase activity
.protein kinase binding
.patched binding
.membrane
.cytosol
.centrosome
  + 5 more...
2 EBI-473850,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
3 EBI-473850,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
4 EBI-473850,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
5 EBI-473850,EBI-2340258 DTX3  
  .protein ubiquitination
.Notch signaling pathway
.ligase activity
.zinc ion binding
.cytoplasm
6 EBI-473850,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
7 EBI-473850,EBI-748248 DDI1  
  .N/A .aspartic-type endopeptidase activity .N/A
8 EBI-473850,EBI-749039 RNF138  
  .protein ubiquitination
.Wnt signaling pathway
.protein kinase binding
.ligase activity
.zinc ion binding
.nucleus
9 EBI-473850,EBI-348482 RNF5  
  .regulation of autophagic vacuole assembly
.ER-associated misfolded protein catabolic process
.protein K48-linked ubiquitination
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.mitochondrial membrane
.integral component of membrane
.endoplasmic reticulum membrane
10 EBI-473850,EBI-739510 TRIM39  
  .positive regulation of apoptotic signaling pathway
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.protein ubiquitination
.apoptotic process
.identical protein binding
.ligase activity
.zinc ion binding
.cytosol
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites75
bladder200
blood32
bone83
bone marrow61
brain86
cervix164
connective tissue87
ear186
embryonic tissue140
eye62
heart156
intestine99
kidney66
larynx127
liver82
lung68
lymph22
lymph node111
mammary gland79
mouth45
muscle141
nerve64
ovary88
pancreas107
parathyroid242
pharynx24
pituitary gland242
placenta63
prostate52
salivary gland98
skin99
spleen37
stomach73
testis45
thymus75
trachea57
uterus176
vascular154
Health State
TissuesTPM*
normal96
bladder carcinoma341
breast (mammary gland) tumor53
cervical tumor86
chondrosarcoma169
colorectal tumor71
gastrointestinal tumor160
germ cell tumor56
glioma102
head and neck tumor37
kidney tumor101
leukemia42
liver tumor41
lung tumor77
lymphoma13
non-neoplasia103
ovarian tumor105
pancreatic tumor66
primitive neuroectodermal tumor of the CNS47
prostate cancer28
retinoblastoma64
skin tumor103
soft tissue/muscle tissue tumor95
uterine tumor133
Developmental Stage
TissuesTPM*
adult91
embryoid body185
blastocyst48
neonate64
fetus127
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue34.9
adrenal gland31.9
appendix37.8
bone marrow25.1
cerebral cortex43
colon52.5
duodenum37.7
esophagus61.6
gallbladder33.3
heart muscle33.5
kidney39.1
liver43.7
lung23
lymph node36.5
ovary20
pancreas15.6
placenta42.1
prostate29.6
salivary gland25
skin25.7
small intestine31.4
spleen23.1
stomach43.4
testis41.8
thyroid gland40.9
urinary bladder45.8
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleHigh
liverLow
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1High
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602846, gene) Huntingtin-interacting protein 2; HIP2OMIM


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