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> Protein (NX_P61224)
Protein (NX_P61224)
Protein
Gene SymbolRAP1B to neXtProt (NX_P61224)
DescriptionRas-related protein Rap-1b
Chromosome12
Location12q15 (69004619 ~ 69054372) to Ensembl
Sequene Features : Isoforms 4, Variants 22, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of synaptic vesicle exocytosis
.regulation of establishment of cell polarity
.regulation of cell junction assembly
  + 9 more...
.protein complex binding
.GDP binding
.GTP binding
.GTPase activity
.extracellular exosome
.membrane
.cell-cell junction
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 22 4
2014-09-19protein level
4 14 4
2014-05-27protein level
4 14 7
2014-02-25protein level
4 14 7
2013-12-09protein level
4 14 7
2013-11-01protein level
4 14 6
2013-09-12protein level
4 14 6
2013-08-17protein level
4 14 6
2013-07-15protein level
4 10 4
2013-06-11protein level
4 10 4
2013-02-12protein level
4 3 15
2012-12-20protein level
1 3 4
2012-10-30protein level
1 3 4
2012-10-07protein level
1 3 4
2012-08-24protein level
1 3 4
2012-07-28protein level
1 3 4
2012-06-08protein level
1 10 4
2012-05-07protein level
1 8 4
2012-04-10protein level
1 8 4
2012-01-13protein level
1 7 4
2011-12-20protein level
1 7 4
2011-11-11protein level
1 7 4
2011-08-23protein level
1 7 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P61224-1
1 0 8 20811.5333
NX_P61224-2
1 0 6 15345.8825
NX_P61224-3
0 0 8 18766.5943
NX_P61224-4
1 0 6 16023.2161
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-358143,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
2 EBI-358143,EBI-722307 RAP1GAP  
  .negative regulation of microvillus assembly
.positive regulation of GTPase activity
.regulation of GTPase activity
  + 2 more...
.protein homodimerization activity
.Ras GTPase binding
.GTPase activator activity
.GTPase activity
.membrane
.cytosol
.Golgi membrane
3 EBI-358143,EBI-365861 RALGDS  
  .regulation of catalytic activity
.neurotrophin TRK receptor signaling pathway
.Ras protein signal transduction
.GTPase regulator activity
.guanyl-nucleotide exchange factor activity
.brush border
.cytosol
.nucleus
4 EBI-358143,EBI-367390 RASSF5  
  .regulation of protein localization to nucleus
.intracellular signal transduction
.positive regulation of protein ubiquitination
  + 2 more...
.metal ion binding .microtubule
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland607
ascites200
bladder602
blood564
bone195
bone marrow225
brain221
cervix144
connective tissue442
ear372
embryonic tissue197
esophagus1091
eye86
heart268
intestine237
kidney222
larynx85
liver155
lung235
lymph112
lymph node200
mammary gland119
mouth166
muscle65
nerve64
ovary118
pancreas93
parathyroid388
pituitary gland60
placenta268
prostate94
salivary gland49
skin161
spleen749
stomach209
testis206
thymus815
thyroid64
tonsil293
trachea173
umbilical cord145
uterus292
vascular851
Health State
TissuesTPM*
normal239
adrenal tumor316
bladder carcinoma56
breast (mammary gland) tumor150
cervical tumor57
chondrosarcoma144
colorectal tumor106
esophageal tumor1101
gastrointestinal tumor202
germ cell tumor395
glioma139
head and neck tumor74
kidney tumor116
leukemia158
liver tumor218
lung tumor48
lymphoma401
non-neoplasia703
ovarian tumor131
pancreatic tumor114
primitive neuroectodermal tumor of the CNS488
prostate cancer57
retinoblastoma150
skin tumor87
soft tissue/muscle tissue tumor119
uterine tumor133
Developmental Stage
TissuesTPM*
adult158
embryoid body185
blastocyst162
neonate997
fetus107
infant1233
juvenile719
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue53.4
adrenal gland48.3
appendix71.6
bone marrow64.5
cerebral cortex18.4
colon47.4
duodenum33
esophagus32.8
gallbladder51.6
heart muscle16.8
kidney37.2
liver27.9
lung55
lymph node77.3
ovary25.8
pancreas12.5
placenta50.6
prostate33.2
salivary gland19.3
skin24.5
small intestine45.1
spleen51.1
stomach38.3
testis36.7
thyroid gland34.8
urinary bladder64.4
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*179530, gene) Ras-related protein rap1b; RAP1BOMIM


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