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> Protein (NX_P61244)
Protein (NX_P61244)
Protein
Gene SymbolMAX to neXtProt (NX_P61244)
DescriptionProtein max
Chromosome14
Location14q23.3 (65472892 ~ 65569413) to Ensembl
Sequene Features : Isoforms 6, Variants 38, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to peptide hormone stimulus
.retina development in camera-type eye
.neuron apoptotic process
  + 6 more...
.sequence-specific DNA binding
.transcription coactivator activity
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
.MLL1 complex
.dendrite
.PML body
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 38 8
2014-09-19protein level
6 31 8
2014-05-27protein level
6 29 8
2014-02-25protein level
6 29 8
2013-12-09protein level
6 26 9
2013-11-01protein level
6 25 7
2013-09-12protein level
6 25 7
2013-08-17protein level
6 25 7
2013-07-15protein level
5 18 5
2013-06-11protein level
5 18 5
2013-02-12protein level
5 7 20
2012-12-20protein level
5 8 20
2012-10-30protein level
5 8 20
2012-10-07protein level
5 8 6
2012-08-24protein level
5 4 6
2012-07-28protein level
5 4 6
2012-06-08protein level
5 10 6
2012-05-07protein level
5 10 6
2012-04-10protein level
3 7 6
2012-01-13protein level
3 8 6
2011-12-20protein level
3 8 6
2011-11-11protein level
3 8 6
2011-08-23protein level
3 8 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P61244-1
0 8 0 18263.8605
NX_P61244-2
1 7 0 17191.3697
NX_P61244-3
1 5 0 12091.8626
NX_P61244-4
3 5 0 15385.344
NX_P61244-5
2 3 0 11447.6814
NX_P61244-6
1 3 0 9592.6797
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-751711,EBI-447544 MYC  
  .positive regulation of response to DNA damage stimulus
.positive regulation of DNA biosynthetic process
.positive regulation of metanephric cap mesenchymal cell proliferation
  + 36 more...
.E-box binding
.repressing transcription factor binding
.protein complex binding
  + 5 more...
.protein complex
.cytosol
.nucleolus
  + 2 more...
2 EBI-751711,EBI-713259 FTH1  
  .membrane organization
.transmembrane transport
.negative regulation of fibroblast proliferation
  + 7 more...
.ferric iron binding
.iron ion binding
.ferroxidase activity
.extracellular exosome
.intracellular ferritin complex
.cytosol
.nucleus
3 EBI-751711,EBI-878369 MYCN  
  .negative regulation of reactive oxygen species metabolic process
.branching morphogenesis of an epithelial tube
.negative regulation of astrocyte differentiation
  + 8 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
.chromatin
4 EBI-751711,EBI-752241 MXI1  
  .cytoplasmic sequestering of transcription factor
.negative regulation of cell proliferation
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
5 EBI-751711,EBI-8833637 MXD1  
  .cell proliferation
.multicellular organismal development
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
6 EBI-751711,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
7 EBI-751711,EBI-447470 EPAS1  
  .cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.iron ion homeostasis
  + 18 more...
.protein heterodimerization activity
.histone acetyltransferase binding
.transcription factor binding
  + 4 more...
.nuclear speck
.cytosol
.transcription factor complex
  + 2 more...
8 EBI-10218525,EBI-1048763 UNC45A  
  .chaperone-mediated protein folding
.cell differentiation
.muscle organ development
.N/A .perinuclear region of cytoplasm
.Golgi apparatus
.cytoplasm
.nucleoplasm
9 EBI-751711,EBI-724156 GABBR1  
  .synaptic transmission
.gamma-aminobutyric acid signaling pathway
.negative regulation of adenylate cyclase activity
.adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
.G-protein coupled GABA receptor activity .postsynaptic membrane
.presynaptic membrane
.G-protein coupled receptor heterodimeric complex
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
ascites125
bladder33
blood57
bone111
brain53
cervix123
connective tissue33
embryonic tissue79
esophagus99
eye86
heart22
intestine133
kidney37
larynx468
liver14
lung89
lymph22
lymph node33
mammary gland46
mouth30
muscle56
nerve64
ovary88
pancreas32
placenta24
prostate68
skin75
spleen56
stomach20
testis20
thymus138
thyroid42
trachea19
umbilical cord72
uterus56
vascular19
Health State
TissuesTPM*
normal61
adrenal tumor237
breast (mammary gland) tumor64
cervical tumor28
chondrosarcoma96
colorectal tumor44
gastrointestinal tumor59
germ cell tumor60
glioma74
head and neck tumor97
leukemia52
liver tumor31
lung tumor48
lymphoma27
non-neoplasia62
ovarian tumor105
pancreatic tumor28
primitive neuroectodermal tumor of the CNS157
prostate cancer48
retinoblastoma64
skin tumor87
soft tissue/muscle tissue tumor63
uterine tumor44
Developmental Stage
TissuesTPM*
adult68
embryoid body85
blastocyst65
neonate64
fetus68
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue30.5
adrenal gland31.6
appendix43.4
bone marrow62.4
cerebral cortex27.5
colon33.9
duodenum39.1
esophagus57.5
gallbladder41.7
heart muscle32.7
kidney31.1
liver18.1
lung37.4
lymph node63.1
ovary48.6
pancreas13.7
placenta36.2
prostate37
salivary gland35.5
skin35.9
small intestine40.6
spleen54.3
stomach32.7
testis23.4
thyroid gland37.6
urinary bladder51.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastHigh
bronchusLow
cerebellumMedium
cerebral cortexLow
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleLow
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryHigh
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*154950, gene) Max protein; MAXOMIM


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