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> Protein (NX_P61289)
Protein (NX_P61289)
Protein
Gene SymbolPSME3 to neXtProt (NX_P61289)
DescriptionProteasome activator complex subunit 3
Chromosome17
Location17q21.31 (40976402 ~ 40995774) to Ensembl
Sequene Features : Isoforms 3, Variants 18, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.MDM2/MDM4 family protein binding
.endopeptidase activator activity
.identical protein binding
.p53 binding
.membrane
.proteasome activator complex
.cytosol
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 18 12
2014-09-19protein level
3 10 12
2014-05-27protein level
2 10 12
2014-02-25protein level
2 9 14
2013-12-09protein level
2 6 14
2013-11-01protein level
2 6 10
2013-09-12protein level
2 6 12
2013-08-17protein level
2 6 9
2013-07-15protein level
2 4 6
2013-06-11protein level
2 4 6
2013-02-12protein level
2 1 10
2012-12-20protein level
2 2 9
2012-10-30protein level
2 2 10
2012-10-07protein level
2 2 5
2012-08-24protein level
2 2 5
2012-07-28protein level
2 2 5
2012-06-08protein level
2 5 5
2012-05-07protein level
2 5 5
2012-04-10protein level
2 5 5
2012-01-13protein level
2 4 5
2011-12-20protein level
2 4 5
2011-11-11protein level
2 4 5
2011-08-23protein level
2 4 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P61289-1
0 13 0 29487.474
NX_P61289-2
1 13 0 30867.1358
NX_P61289-3
1 13 0 30870.1364
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-355546,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
2 EBI-355546,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-355546,EBI-945751 COIL  
  .N/A .identical protein binding
.protein C-terminus binding
.membrane
.Cajal body
.cytoplasm
  + 3 more...
4 EBI-355546,EBI-945980 ATN1  
  .neuron apoptotic process
.maintenance of cell polarity
.cell migration
  + 4 more...
.protein domain specific binding
.transcription corepressor activity
.perinuclear region of cytoplasm
.cell junction
.nuclear matrix
  + 3 more...
5 EBI-355546,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
6 EBI-355546,EBI-10233719 DIP2A  
  .regulation of apoptotic process
.negative regulation of gene expression
.multicellular organismal development
.catalytic activity .cell surface
.nucleus
7 EBI-355546,EBI-597063 ZCCHC10  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
8 EBI-355546,EBI-752102 TNFAIP8L1  
  .negative regulation of TOR signaling .N/A .cytoplasm
9 EBI-355546,EBI-769261 EAF1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .ELL-EAF complex
.nuclear speck
.Cajal body
  + 3 more...
10 EBI-355546,EBI-357275 PFDN5  
  .negative regulation of canonical Wnt signaling pathway
.retina development in camera-type eye
.'de novo' posttranslational protein folding
  + 4 more...
.transcription corepressor activity .prefoldin complex
.cytoplasm
.nucleus
11 EBI-355546,EBI-2932492 TXN2  
  .oxidation-reduction process
.response to axon injury
.cell redox homeostasis
  + 12 more...
.peptide-methionine (R)-S-oxide reductase activity
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.protein disulfide oxidoreductase activity
.peptide-methionine (S)-S-oxide reductase activity
.neuronal cell body
.dendrite
.mitochondrial matrix
  + 2 more...
12 EBI-355546,EBI-748297 BBS2  
  .protein localization to ciliary membrane
.regulation of cilium beat frequency involved in ciliary motility
.cilium morphogenesis
  + 23 more...
.RNA polymerase II repressing transcription factor binding .ciliary membrane
.ciliary basal body
.BBSome
  + 3 more...
13 EBI-355546,EBI-976466 SMURF1  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of dendrite extension
.activation of mitophagy in response to mitochondrial depolarization
  + 18 more...
.R-SMAD binding
.I-SMAD binding
.ubiquitin protein ligase activity
  + 4 more...
.extracellular exosome
.neuronal cell body
.axon
  + 5 more...
14 EBI-355546,EBI-740924 PRR13  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .nucleus
15 EBI-355546,EBI-717201 SPG7  
  .anterograde axon cargo transport
.nervous system development
.mitochondrion organization
.proteolysis
.unfolded protein binding
.zinc ion binding
.peptidase activity
  + 2 more...
.mitochondrial membrane
.integral component of membrane
.mitochondrion
16 EBI-355546,EBI-1161222 FBXO7  
  .negative regulation of G1/S transition of mitotic cell cycle
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of lymphocyte differentiation
  + 5 more...
.ubiquitin-protein transferase activity .protein complex
.cytosol
.mitochondrion
  + 3 more...
17 EBI-355546,EBI-81196 NCOA3  
  .regulation of RNA biosynthetic process
.mammary gland branching involved in thelarche
.labyrinthine layer morphogenesis
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.thyroid hormone receptor binding
  + 7 more...
.extracellular exosome
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites225
bladder100
blood171
bone125
bone marrow184
brain237
cervix247
connective tissue127
ear124
embryonic tissue155
esophagus198
eye172
heart122
intestine280
kidney161
larynx85
liver73
lung149
lymph474
lymph node111
mammary gland171
mouth1012
muscle225
nerve128
ovary187
pancreas70
parathyroid48
pharynx49
placenta105
prostate200
salivary gland197
skin270
spleen318
stomach156
testis179
thymus238
thyroid42
tonsil352
trachea212
uterus133
vascular425
Health State
TissuesTPM*
normal160
bladder carcinoma56
breast (mammary gland) tumor204
cervical tumor231
chondrosarcoma193
colorectal tumor346
esophageal tumor231
gastrointestinal tumor185
germ cell tumor292
glioma93
head and neck tumor545
kidney tumor58
leukemia190
liver tumor124
lung tumor175
lymphoma318
non-neoplasia72
ovarian tumor157
pancreatic tumor47
primitive neuroectodermal tumor of the CNS401
prostate cancer192
retinoblastoma366
skin tumor295
soft tissue/muscle tissue tumor135
uterine tumor133
Developmental Stage
TissuesTPM*
adult154
embryoid body57
blastocyst260
neonate386
fetus211
infant212
juvenile359
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue46.6
adrenal gland40.8
appendix55
bone marrow39.8
cerebral cortex42
colon48.6
duodenum42.7
esophagus65.3
gallbladder46.4
heart muscle41.5
kidney46.5
liver20.6
lung37.4
lymph node64.3
ovary26.8
pancreas27.4
placenta43.1
prostate36.3
salivary gland33.2
skin38.9
small intestine43.2
spleen39.4
stomach44
testis59.1
thyroid gland57.6
urinary bladder64.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605129, gene) Proteasome activator subunit 3; PSME3OMIM


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