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> Protein (NX_P61457)
Protein (NX_P61457)
Protein
Gene SymbolPCBD1 to neXtProt (NX_P61457)
DescriptionPterin-4-alpha-carbinolamine dehydratase
Chromosome10
Location10q22.1 (72642037 ~ 72648541) to Ensembl
Sequene Features : Isoforms 1, Variants 15, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein heterooligomerization
.protein homotetramerization
.positive regulation of transcription, DNA-templated
  + 6 more...
.identical protein binding
.4-alpha-hydroxytetrahydrobiopterin dehydratase activity
.phenylalanine 4-monooxygenase activity
.transcription coactivator activity
.extracellular exosome
.cytosol
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 15 3
2014-09-19protein level
1 13 3
2014-05-27protein level
1 13 4
2014-02-25protein level
1 13 4
2013-12-09protein level
1 12 4
2013-11-01protein level
1 12 2
2013-09-12protein level
1 12 2
2013-08-17protein level
1 12 2
2013-07-15protein level
1 9 2
2013-06-11protein level
1 9 2
2013-02-12protein level
1 6 3
2012-12-20protein level
1 6 3
2012-10-30protein level
1 6 3
2012-10-07protein level
1 6 3
2012-08-24protein level
1 5 3
2012-07-28protein level
1 5 3
2012-06-08protein level
1 5 3
2012-05-07protein level
1 5 3
2012-04-10protein level
1 5 3
2012-01-13protein level
1 5 3
2011-12-20protein level
1 5 3
2011-11-11protein level
1 5 2
2011-08-23protein level
1 5 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P61457-1
5 0 0 11991.9817
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740475,EBI-77613 APP  
  .membrane organization
.smooth endoplasmic reticulum calcium ion homeostasis
.neuron apoptotic process
  + 41 more...
.PTB domain binding
.transition metal ion binding
.identical protein binding
  + 7 more...
.extracellular exosome
.spindle midzone
.perinuclear region of cytoplasm
  + 27 more...
2 EBI-740475,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
3 EBI-740475,EBI-10224676 TFF3  
  .digestion
.defense response
.N/A .extracellular exosome
.cytoplasm
.proteinaceous extracellular matrix
.extracellular region
4 EBI-740475,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
5 EBI-740475,EBI-396258 ACIN1  
  .activation of mitophagy in response to mitochondrial depolarization
.negative regulation of mRNA splicing, via spliceosome
.positive regulation of monocyte differentiation
  + 10 more...
.poly(A) RNA binding
.enzyme binding
.ATPase activity
  + 2 more...
.ASAP complex
.nuclear speck
.plasma membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites100
bladder66
bone111
bone marrow41
brain12
connective tissue6
embryonic tissue9
esophagus49
eye43
heart22
intestine60
kidney33
liver9
lung50
lymph node55
mammary gland19
muscle18
nerve64
ovary118
pancreas262
parathyroid97
pharynx24
placenta14
prostate63
skin37
stomach41
testis25
thyroid42
umbilical cord290
uterus30
vascular19
Health State
TissuesTPM*
normal26
breast (mammary gland) tumor21
chondrosarcoma36
colorectal tumor53
esophageal tumor57
gastrointestinal tumor84
germ cell tumor11
glioma27
kidney tumor14
leukemia21
liver tumor10
lung tumor9
ovarian tumor144
pancreatic tumor390
primitive neuroectodermal tumor of the CNS15
prostate cancer86
retinoblastoma64
skin tumor31
soft tissue/muscle tissue tumor15
uterine tumor44
Developmental Stage
TissuesTPM*
adult34
embryoid body14
neonate128
fetus17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue50.4
adrenal gland71.6
appendix24.6
bone marrow9.9
cerebral cortex19.4
colon57.5
duodenum32.9
esophagus38.6
gallbladder36.2
heart muscle89.5
kidney102.9
liver169.6
lung44.2
lymph node20.7
ovary44.1
pancreas59.6
placenta24.2
prostate58.8
salivary gland26.8
skin13.6
small intestine44.6
spleen19.8
stomach42.3
testis20
thyroid gland62.7
urinary bladder47.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*126090, gene) Pterin-4-alpha-carbinolamine dehydratase 1; PCBD1OMIM
2(#264070, phenotype) Hyperphenylalaninemia, bh4-deficient, d; HPABH4DOMIM


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