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> Protein (NX_P61964)
Protein (NX_P61964)
Protein
Gene SymbolWDR5 to neXtProt (NX_P61964)
DescriptionWD repeat-containing protein 5
Chromosome9
Location9q34.2 (137000487 ~ 137025093) to Ensembl
Sequene Features : Isoforms 1, Variants 24, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.histone H3-K4 methylation
.histone H4-K16 acetylation
.histone H4-K8 acetylation
  + 6 more...
.N/A .MLL1 complex
.Set1C/COMPASS complex
.histone methyltransferase complex
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 24 5
2014-09-19protein level
1 19 5
2014-05-27protein level
1 19 5
2014-02-25protein level
1 19 5
2013-12-09protein level
1 13 5
2013-11-01protein level
1 11 2
2013-09-12protein level
1 11 1
2013-08-17protein level
1 11 1
2013-07-15protein level
1 7 1
2013-06-11protein level
1 7 1
2013-02-12protein level
1 1 2
2012-12-20protein level
1 1 2
2012-10-30protein level
1 4 2
2012-10-07protein level
1 4 2
2012-08-24protein level
1 4 2
2012-07-28protein level
1 4 2
2012-06-08protein level
1 11 2
2012-05-07protein level
1 10 2
2012-04-10protein level
1 10 2
2012-01-13protein level
1 8 2
2011-12-20protein level
1 8 2
2011-11-11protein level
1 8 2
2011-08-23protein level
1 8 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P61964-1
14 0 2 36565.3495
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-540834,EBI-396176 HCFC1  
  .protein stabilization
.positive regulation of cell cycle
.histone H4-K16 acetylation
  + 12 more...
.identical protein binding
.transcription coactivator activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.MLL1 complex
.MLL5-L complex
.Set1C/COMPASS complex
  + 7 more...
2 EBI-540834,EBI-79722 HIST1H3A  
  .regulation of gene silencing
.protein heterotetramerization
.negative regulation of gene expression, epigenetic
  + 10 more...
.histone binding
.DNA binding
.extracellular exosome
.protein complex
.membrane
  + 6 more...
3 EBI-540834,EBI-591370 KMT2A  
  .positive regulation of cellular response to drug
.regulation of histone H3-K9 acetylation
.histone H3-K4 trimethylation
  + 16 more...
.lysine-acetylated histone binding
.unmethylated CpG binding
.transcription regulatory region DNA binding
  + 8 more...
.MLL1 complex
.histone methyltransferase complex
.cytoplasm
  + 2 more...
4 EBI-540834,EBI-2556750 HSF2  
  .positive regulation of transcription from RNA polymerase II promoter
.spermatogenesis
.transcription from RNA polymerase II promoter
.transcription coactivator activity
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  + 2 more...
.cytoplasm
.nucleus
5 EBI-540834,EBI-78670 NCOA6  
  .labyrinthine layer blood vessel development
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 14 more...
.thyroid hormone receptor binding
.retinoid X receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 4 more...
.intracellular membrane-bounded organelle
.histone methyltransferase complex
.transcription factor complex
  + 2 more...
6 EBI-540834,EBI-592823 RBBP5  
  .histone H3-K4 methylation
.response to estrogen
.cellular response to DNA damage stimulus
  + 3 more...
.transcription regulatory region DNA binding
.methylated histone binding
.MLL1 complex
.Set1C/COMPASS complex
.histone methyltransferase complex
  + 3 more...
7 EBI-540834,EBI-740244 KANSL1  
  .histone H4-K16 acetylation
.histone H4-K8 acetylation
.histone H4-K5 acetylation
.chromatin organization
.N/A .MLL1 complex
.nucleoplasm
.nucleus
  + 2 more...
8 EBI-540834,EBI-948013 KAT6A  
  .cellular senescence
.face morphogenesis
.positive regulation of transcription, DNA-templated
  + 14 more...
.acetyltransferase activity
.zinc ion binding
.transcription factor binding
  + 4 more...
.MOZ/MORF histone acetyltransferase complex
.PML body
.Golgi apparatus
  + 4 more...
9 EBI-540834,EBI-2560840 KANSL2  
  .histone H4-K16 acetylation
.histone H4-K8 acetylation
.histone H4-K5 acetylation
.chromatin organization
.N/A .nucleoplasm
.histone acetyltransferase complex
10 EBI-540834,EBI-1169146 CHD8  
  .negative regulation of fibroblast apoptotic process
.negative regulation of canonical Wnt signaling pathway
.canonical Wnt signaling pathway
  + 12 more...
.histone binding
.methylated histone binding
.DNA-dependent ATPase activity
  + 6 more...
.MLL1 complex
.protein complex
.nucleoplasm
.nucleus
11 EBI-540834,EBI-10182361 MBIP  
  .histone H3 acetylation
.chromatin organization
.inactivation of MAPK activity involved in osmosensory signaling pathway
.identical protein binding
.protein kinase inhibitor activity
.cytoplasm
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
12 EBI-540834,EBI-765774 KMT2B  
  .histone H3-K4 trimethylation
.regulation of histone H3-K4 methylation
.histone H3-K4 methylation
  + 7 more...
.histone methyltransferase activity (H3-K4 specific)
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.histone methyltransferase complex
.nucleoplasm
.nucleus
13 EBI-540834,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites75
blood40
bone69
brain39
cervix82
connective tissue33
embryonic tissue46
eye67
heart44
intestine56
kidney61
liver19
lung50
lymph203
lymph node178
mammary gland33
mouth45
muscle56
ovary59
pancreas23
placenta31
prostate47
salivary gland49
skin66
spleen18
stomach73
testis78
thymus87
thyroid42
uterus77
vascular19
Health State
TissuesTPM*
normal31
breast (mammary gland) tumor42
cervical tumor86
chondrosarcoma96
colorectal tumor71
gastrointestinal tumor92
germ cell tumor87
glioma149
head and neck tumor29
kidney tumor116
leukemia116
liver tumor20
lung tumor77
lymphoma207
non-neoplasia51
ovarian tumor52
pancreatic tumor47
primitive neuroectodermal tumor of the CNS78
prostate cancer67
retinoblastoma150
skin tumor95
soft tissue/muscle tissue tumor79
uterine tumor88
Developmental Stage
TissuesTPM*
adult38
embryoid body42
blastocyst65
neonate32
fetus35
infant127
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.6
adrenal gland9.7
appendix12.4
bone marrow11.8
cerebral cortex10.6
colon13.4
duodenum13.7
esophagus11.9
gallbladder8.7
heart muscle9.4
kidney10.6
liver6.1
lung10.6
lymph node14.1
ovary15.1
pancreas8.9
placenta13.1
prostate11.9
salivary gland11.6
skin16.3
small intestine13.9
spleen12.9
stomach11.1
testis34.3
thyroid gland11.3
urinary bladder10.7
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*609012, gene) Wd repeat-containing protein 5; WDR5OMIM


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