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> Protein (NX_P61968)
Protein (NX_P61968)
Protein
Gene SymbolLMO4 to neXtProt (NX_P61968)
DescriptionLIM domain transcription factor LMO4
Chromosome1
Location1p22.3 (87794151 ~ 87814606) to Ensembl
Sequene Features : Isoforms 1, Variants 17, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cell activation
.thymus development
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.zinc ion binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.enhancer sequence-specific DNA binding
.transcription factor complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 17 0
2014-09-19protein level
1 14 0
2014-05-27protein level
1 14 0
2014-02-25protein level
1 14 0
2013-12-09protein level
1 12 0
2013-11-01protein level
1 11 0
2013-09-12protein level
1 11 0
2013-08-17protein level
1 11 0
2013-07-15protein level
1 6 0
2013-06-11protein level
1 6 0
2013-02-12protein level
1 2 0
2012-12-20protein level
1 2 0
2012-10-30protein level
1 2 0
2012-10-07protein level
1 2 0
2012-08-24protein level
1 2 0
2012-07-28protein level
1 2 0
2012-06-08protein level
1 2 0
2012-05-07protein level
1 1 0
2012-04-10protein level
1 1 0
2012-01-13protein level
1 2 0
2011-12-20protein level
1 2 0
2011-11-11protein level
1 2 0
2011-08-23protein level
1 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P61968-1
7 0 0 17981.4609
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2798728,EBI-740718 ZBTB43  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
2 EBI-2798728,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
3 EBI-2798728,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
4 EBI-2798728,EBI-618165 GABPB1  
  .positive regulation of transcription from RNA polymerase II promoter
.mitochondrion organization
.organelle organization
  + 2 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.nucleoplasm
.nucleus
5 EBI-2798728,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
6 EBI-2798728,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
7 EBI-2798728,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
8 EBI-2798728,EBI-347263 SMAD4  
  .nephrogenic mesenchyme morphogenesis
.metanephric mesenchyme morphogenesis
.response to transforming growth factor beta
  + 49 more...
.R-SMAD binding
.I-SMAD binding
.metal ion binding
  + 9 more...
.SMAD protein complex
.activin responsive factor complex
.cytosol
  + 6 more...
9 EBI-2798728,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
10 EBI-2798728,EBI-10203843 NONO  
  .negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.negative regulation of transcription, DNA-templated
.regulation of circadian rhythm
  + 6 more...
.poly(A) RNA binding
.identical protein binding
.core promoter binding
.nucleotide binding
.paraspeckles
.nuclear speck
.nuclear matrix
  + 4 more...
11 EBI-2798728,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
12 EBI-2798728,EBI-1042535 ERCC6L  
  .cell division
.small GTPase mediated signal transduction
.mitotic nuclear division
.mitotic cell cycle
.ATP binding
.helicase activity
.DNA binding
.membrane
.plasma membrane
.cytosol
  + 4 more...
13 EBI-2798728,EBI-3891843 AMOT  
  .positive regulation of stress fiber assembly
.positive regulation of cell size
.positive regulation of blood vessel endothelial cell migration
  + 16 more...
.angiostatin binding
.receptor activity
.endocytic vesicle
.lamellipodium
.integral component of membrane
  + 8 more...
14 EBI-2798728,EBI-1105124 PDE4DIP  
  .cellular protein complex assembly .enzyme binding .myofibril
.centrosome
.Golgi apparatus
  + 2 more...
15 EBI-2798728,EBI-2556193 KANK2  
  .negative regulation of G1/S transition of mitotic cell cycle
.negative regulation of vitamin D receptor signaling pathway
.negative regulation of programmed cell death
  + 5 more...
.N/A .mitochondrion
.cytoplasm
16 EBI-2798728,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
17 EBI-2798728,EBI-10219092 GRHL2  
  .epithelium migration
.tight junction assembly
.lung epithelial cell differentiation
  + 22 more...
.sequence-specific DNA binding
.chromatin DNA binding
.sequence-specific DNA binding transcription factor activity
.intronic transcription regulatory region sequence-specific DNA binding
.membrane
.cell-cell junction
.nucleus
18 EBI-2798728,EBI-677177 LDB1  
  .positive regulation of hemoglobin biosynthetic process
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription, DNA-templated
  + 18 more...
.protein homodimerization activity
.LIM domain binding
.enzyme binding
  + 4 more...
.protein complex
.transcription factor complex
.nucleus
.nuclear chromatin
19 EBI-2798728,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
20 EBI-2798728,EBI-10181113 KIAA1958  
  .N/A .N/A .N/A
21 EBI-2798728,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
22 EBI-2798728,EBI-10213894 ZNF397  
  .transcription, DNA-templated .metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleus
23 EBI-2798728,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
24 EBI-2798728,EBI-743488 CEP170P1  
  .N/A .identical protein binding .N/A
25 EBI-2798728,EBI-10203615 RBBP8  
  .meiotic cell cycle
.cell division
.G2 DNA damage checkpoint
  + 10 more...
.damaged DNA binding
.RNA polymerase II transcription corepressor activity
.RNA polymerase II repressing transcription factor binding
.single-stranded DNA endodeoxyribonuclease activity
.transcriptional repressor complex
.nucleolus
.nucleoplasm
.nucleus
26 EBI-2798728,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
27 EBI-2798728,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
bladder133
bone111
brain128
cervix20
connective tissue53
ear372
embryonic tissue37
eye105
heart11
intestine43
kidney37
larynx340
liver19
lung80
lymph90
lymph node33
mammary gland19
mouth15
nerve64
ovary68
pancreas18
pituitary gland60
placenta84
prostate26
skin28
spleen37
stomach62
testis25
thyroid21
uterus51
vascular19
Health State
TissuesTPM*
normal65
bladder carcinoma227
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma96
colorectal tumor35
gastrointestinal tumor42
germ cell tumor49
glioma74
head and neck tumor74
kidney tumor87
liver tumor31
lung tumor48
lymphoma69
non-neoplasia82
ovarian tumor26
pancreatic tumor9
retinoblastoma172
skin tumor15
soft tissue/muscle tissue tumor39
uterine tumor66
Developmental Stage
TissuesTPM*
adult54
embryoid body28
blastocyst16
fetus140
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue39.6
adrenal gland15.7
appendix29.4
bone marrow17.2
cerebral cortex110.4
colon32.3
duodenum26
esophagus58.6
gallbladder57.7
heart muscle33.8
kidney27.1
liver21
lung39.5
lymph node30.1
ovary37.4
pancreas12.5
placenta60.2
prostate54.5
salivary gland78.9
skin39.6
small intestine42
spleen36.8
stomach89.3
testis33.2
thyroid gland25.2
urinary bladder44.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603129, gene) Lim domain only 4; LMO4OMIM


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