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> Protein (NX_P61978)
Protein (NX_P61978)
Protein
Gene SymbolHNRNPK to neXtProt (NX_P61978)
DescriptionHeterogeneous nuclear ribonucleoprotein K
Chromosome9
Location9q21.32 (86582998 ~ 86595569) to Ensembl
Sequene Features : Isoforms 3, Variants 53, PTMs 34 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
.positive regulation of receptor-mediated endocytosis
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.poly(A) RNA binding
.RNA binding
.single-stranded DNA binding
  + 2 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cell projection
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 53 34
2014-09-19protein level
3 31 34
2014-05-27protein level
3 31 34
2014-02-25protein level
3 30 31
2013-12-09protein level
3 30 31
2013-11-01protein level
3 26 25
2013-09-12protein level
3 26 25
2013-08-17protein level
3 26 25
2013-07-15protein level
3 18 20
2013-06-11protein level
3 18 20
2013-02-12protein level
3 3 43
2012-12-20protein level
3 3 43
2012-10-30protein level
3 3 43
2012-10-07protein level
3 3 15
2012-08-24protein level
3 0 15
2012-07-28protein level
3 0 15
2012-06-08protein level
3 1 15
2012-05-07protein level
3 4 15
2012-04-10protein level
3 4 15
2012-01-13protein level
3 2 15
2011-12-20protein level
3 2 15
2011-11-11protein level
3 2 15
2011-08-23protein level
3 2 13
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P61978-1
0 26 0 50944.2579
NX_P61978-2
0 27 0 50996.2375
NX_P61978-3
1 26 0 48532.0288
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-304185,EBI-448680 AURKA  
  .neuron projection extension
.positive regulation of oocyte maturation
.negative regulation of spindle checkpoint
  + 21 more...
.histone serine kinase activity
.protein kinase binding
.ATP binding
  + 3 more...
.meiotic spindle
.mitotic spindle
.spindle midzone
  + 14 more...
2 EBI-7060731,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-304185,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
4 EBI-304185,EBI-743526 RBMX  
  .cellular response to interleukin-1
.protein homooligomerization
.positive regulation of mRNA splicing, via spliceosome
  + 10 more...
.poly(A) RNA binding
.mRNA binding
.single-stranded RNA binding
  + 4 more...
.catalytic step 2 spliceosome
.extracellular exosome
.supraspliceosomal complex
  + 6 more...
5 EBI-304185,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
6 EBI-304185,EBI-2803328 PRR3  
  .N/A .metal ion binding
.poly(A) RNA binding
.N/A
7 EBI-304185,EBI-2949699 RBM3  
  .positive regulation of translation
.production of miRNAs involved in gene silencing by miRNA
.response to cold
  + 3 more...
.poly(A) RNA binding
.ribosomal large subunit binding
.RNA binding
.nucleotide binding
.dendrite
.cytoplasm
.nucleus
8 EBI-304185,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
9 EBI-304185,EBI-538850 CIRBP  
  .mRNA stabilization
.positive regulation of translation
.stress granule assembly
  + 3 more...
.small ribosomal subunit rRNA binding
.poly(A) RNA binding
.translation repressor activity
  + 2 more...
.cytoplasmic stress granule
.cytoplasm
.nucleoplasm
.nucleus
10 EBI-304185,EBI-10240849 ZNF792  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
11 EBI-304185,EBI-2871865 DALRD3  
  .arginyl-tRNA aminoacylation .ATP binding
.arginine-tRNA ligase activity
.N/A
12 EBI-304185,EBI-10244057 C6orf226  
  .N/A .N/A .N/A
13 EBI-304185,EBI-10219231 ZNF385C  
  .N/A .zinc ion binding
.nucleic acid binding
.nucleus
14 EBI-304185,EBI-535849 HNRNPLL  
  .positive regulation of RNA splicing
.mRNA processing
.poly(A) RNA binding
.mRNA binding
.nucleotide binding
.ribonucleoprotein complex
.membrane
.nucleus
15 EBI-304185,EBI-448771 DOCK2  
  .positive regulation of phagocytosis
.regulation of defense response to virus by virus
.alpha-beta T cell proliferation
  + 12 more...
.T cell receptor binding
.Rac guanyl-nucleotide exchange factor activity
.extracellular exosome
.membrane
.endomembrane system
  + 2 more...
16 EBI-304185,EBI-945792 QKI  
  .3'-UTR-mediated mRNA destabilization
.mRNA transport
.long-chain fatty acid biosynthetic process
  + 8 more...
.poly(A) RNA binding
.mRNA binding
.cytoplasm
.nucleus
17 EBI-304185,EBI-78738 PRMT1  
  .negative regulation of megakaryocyte differentiation
.histone H4-R3 methylation
.neuron projection development
  + 7 more...
.poly(A) RNA binding
.histone methyltransferase activity (H4-R3 specific)
.identical protein binding
  + 5 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
18 EBI-304185,EBI-2337775 TP63  
  .positive regulation of apoptotic signaling pathway
.negative regulation of cellular senescence
.negative regulation of mesoderm development
  + 54 more...
.WW domain binding
.metal ion binding
.transcription regulatory region DNA binding
  + 10 more...
.dendrite
.cytosol
.rough endoplasmic reticulum
  + 6 more...
19 EBI-304185,EBI-717201 SPG7  
  .anterograde axon cargo transport
.nervous system development
.mitochondrion organization
.proteolysis
.unfolded protein binding
.zinc ion binding
.peptidase activity
  + 2 more...
.mitochondrial membrane
.integral component of membrane
.mitochondrion
20 EBI-304185,EBI-740818 RASD1  
  .negative regulation of transcription, DNA-templated
.metabolic process
.small GTPase mediated signal transduction
  + 3 more...
.GTP binding
.GTPase activity
.perinuclear region of cytoplasm
.plasma membrane
.nucleus
21 EBI-304185,EBI-10329013 PCDHB14  
  .calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
.synapse assembly
.synaptic transmission
.homophilic cell adhesion via plasma membrane adhesion molecules
.calcium ion binding .integral component of membrane
.plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland637
ascites351
bladder904
blood728
bone237
bone marrow533
brain611
cervix329
connective tissue308
ear186
embryonic tissue624
esophagus1141
eye387
heart435
intestine336
kidney502
larynx1235
liver331
lung271
lymph248
lymph node211
mammary gland793
mouth665
muscle282
nerve579
ovary305
pancreas149
parathyroid339
pharynx1276
pituitary gland181
placenta289
prostate300
salivary gland197
skin498
spleen618
stomach376
testis539
thymus1505
thyroid364
tonsil58
trachea444
umbilical cord290
uterus547
vascular464
Health State
TissuesTPM*
normal433
adrenal tumor632
bladder carcinoma796
breast (mammary gland) tumor945
cervical tumor434
chondrosarcoma338
colorectal tumor328
esophageal tumor1101
gastrointestinal tumor430
germ cell tumor923
glioma335
head and neck tumor627
kidney tumor551
leukemia518
liver tumor479
lung tumor243
lymphoma484
non-neoplasia351
ovarian tumor367
pancreatic tumor152
primitive neuroectodermal tumor of the CNS795
prostate cancer346
retinoblastoma775
skin tumor494
soft tissue/muscle tissue tumor359
uterine tumor565
Developmental Stage
TissuesTPM*
adult392
embryoid body514
blastocyst602
neonate1190
fetus479
infant1275
juvenile1223
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue136.1
adrenal gland186.1
appendix195.6
bone marrow273.8
cerebral cortex122.6
colon143.6
duodenum149.4
esophagus138.8
gallbladder139.3
heart muscle113.1
kidney140.2
liver100.4
lung140.2
lymph node217.2
ovary160.7
pancreas67.4
placenta160.6
prostate152.8
salivary gland102.9
skin134.1
small intestine152.9
spleen173.2
stomach144.4
testis120.1
thyroid gland159.8
urinary bladder163.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600712, gene) Heterogeneous nuclear ribonucleoprotein k; HNRNPKOMIM


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