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> Protein (NX_P62140)
Protein (NX_P62140)
Protein
Gene SymbolPPP1CB to neXtProt (NX_P62140)
DescriptionSerine/threonine-protein phosphatase PP1-beta catalytic subunit
Chromosome2
Location2p23.2 (28974506 ~ 29025806) to Ensembl
Sequene Features : Isoforms 1, Variants 38, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell division
.small molecule metabolic process
.entrainment of circadian clock by photoperiod
  + 13 more...
.myosin-light-chain-phosphatase activity
.metal ion binding
.protein kinase binding
  + 2 more...
.PTW/PP1 phosphatase complex
.MLL5-L complex
.extracellular exosome
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 38 5
2014-09-19protein level
1 23 5
2014-05-27protein level
1 23 13
2014-02-25protein level
1 23 13
2013-12-09protein level
1 21 13
2013-11-01protein level
1 21 10
2013-09-12protein level
1 21 10
2013-08-17protein level
1 21 10
2013-07-15protein level
1 10 2
2013-06-11protein level
1 10 2
2013-02-12protein level
1 3 5
2012-12-20protein level
1 3 5
2012-10-30protein level
1 3 5
2012-10-07protein level
1 3 5
2012-08-24protein level
1 3 5
2012-07-28protein level
1 3 5
2012-06-08protein level
1 4 5
2012-05-07protein level
1 2 5
2012-04-10protein level
1 2 5
2012-01-13protein level
1 5 5
2011-12-20protein level
1 5 5
2011-11-11protein level
1 5 5
2011-08-23protein level
1 5 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P62140-1
8 0 10 37162.5217
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-352350,EBI-349905 BRCA1  
  .positive regulation of histone H4-K16 acetylation
.positive regulation of histone H3-K9 acetylation
.negative regulation of reactive oxygen species metabolic process
  + 51 more...
.androgen receptor binding
.transcription regulatory region DNA binding
.ubiquitin protein ligase binding
  + 9 more...
.BRCA1-A complex
.protein complex
.BRCA1-BARD1 complex
  + 9 more...
2 EBI-352350,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
3 EBI-352350,EBI-10251630 PPP1R2P3  
  .regulation of phosphoprotein phosphatase activity
.regulation of signal transduction
.glycogen metabolic process
.protein phosphatase inhibitor activity .N/A
4 EBI-352350,EBI-710402 PPP1R16A  
  .N/A .protein phosphatase type 1 regulator activity .plasma membrane
5 EBI-352350,EBI-5235958 CSRNP2  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of phosphatase activity
.apoptotic process
.sequence-specific DNA binding
.phosphatase binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.nucleus
6 EBI-352350,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
7 EBI-352350,EBI-2506727 PPP1R3C  
  .small molecule metabolic process
.dephosphorylation
.glucose metabolic process
  + 2 more...
.protein phosphatase regulator activity
.protein serine/threonine phosphatase activity
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites75
bladder368
blood171
bone97
bone marrow143
brain168
cervix185
connective tissue127
embryonic tissue112
esophagus446
eye134
heart223
intestine198
kidney170
larynx213
liver160
lung140
lymph22
lymph node401
mammary gland191
mouth302
muscle263
nerve64
ovary98
pancreas42
parathyroid339
pharynx49
pituitary gland242
placenta219
prostate216
salivary gland49
skin94
spleen56
stomach146
testis126
thymus338
thyroid171
trachea637
uterus465
vascular561
Health State
TissuesTPM*
normal171
adrenal tumor79
bladder carcinoma341
breast (mammary gland) tumor139
cervical tumor86
chondrosarcoma108
colorectal tumor151
esophageal tumor463
gastrointestinal tumor84
germ cell tumor125
glioma102
head and neck tumor224
kidney tumor203
leukemia137
liver tumor249
lung tumor9
lymphoma55
non-neoplasia144
ovarian tumor118
pancreatic tumor57
primitive neuroectodermal tumor of the CNS133
prostate cancer231
retinoblastoma193
skin tumor95
soft tissue/muscle tissue tumor175
uterine tumor355
Developmental Stage
TissuesTPM*
adult198
embryoid body157
blastocyst97
neonate96
fetus134
infant170
juvenile269
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue74
adrenal gland76.2
appendix75.4
bone marrow63.5
cerebral cortex79.4
colon104.9
duodenum75.6
esophagus220.6
gallbladder104.3
heart muscle136.3
kidney64.3
liver38.7
lung62.9
lymph node57.1
ovary81
pancreas32.8
placenta73.3
prostate131.1
salivary gland82.4
skin57.4
small intestine68.4
spleen59.7
stomach75.7
testis52.4
thyroid gland78.1
urinary bladder113.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowLow
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleHigh
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
spleenMedium
stomach 1High
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600590, gene) Protein phosphatase 1, catalytic subunit, beta isoform; PPP1CBOMIM


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