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> Protein (NX_P62158)
Protein (NX_P62158)
Protein
Gene SymbolCALM2 to neXtProt (NX_P62158)
DescriptionCalmodulin
Chromosome2
Location2p21 (47387221 ~ 47403740) to Ensembl
Sequene Features : Isoforms 1, Variants 8, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cell communication by electrical coupling involved in cardiac conduction
.regulation of high voltage-gated calcium channel activity
.positive regulation of protein serine/threonine kinase activity
  + 48 more...
.protein phosphatase activator activity
.ion channel binding
.protein serine/threonine kinase activator activity
  + 8 more...
.extracellular exosome
.vesicle
.growth cone
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 8 14
2015-01-01protein level
1 8 14
2015-01-01protein level
1 8 14
2014-09-19protein level
1 31 14
2014-09-19protein level
1 31 14
2014-09-19protein level
1 31 14
2014-05-27protein level
1 31 14
2014-05-27protein level
1 31 14
2014-05-27protein level
1 31 14
2014-02-25protein level
1 30 13
2014-02-25protein level
1 30 13
2014-02-25protein level
1 30 13
2013-12-09protein level
1 27 13
2013-12-09protein level
1 27 13
2013-12-09protein level
1 27 13
2013-11-01protein level
1 25 13
2013-11-01protein level
1 25 13
2013-11-01protein level
1 25 13
2013-09-12protein level
1 25 13
2013-09-12protein level
1 25 13
2013-09-12protein level
1 25 13
2013-08-17protein level
1 25 13
2013-08-17protein level
1 25 13
2013-08-17protein level
1 25 13
2013-07-15protein level
1 17 10
2013-07-15protein level
1 17 10
2013-07-15protein level
1 17 10
2013-06-11protein level
1 17 10
2013-06-11protein level
1 17 10
2013-06-11protein level
1 17 10
2013-02-12protein level
1 5 10
2013-02-12protein level
1 5 10
2013-02-12protein level
1 5 10
2012-12-20protein level
1 5 10
2012-12-20protein level
1 5 10
2012-12-20protein level
1 5 10
2012-10-30protein level
1 5 10
2012-10-30protein level
1 5 10
2012-10-30protein level
1 5 10
2012-10-07protein level
1 5 10
2012-10-07protein level
1 5 10
2012-10-07protein level
1 5 10
2012-08-24protein level
1 4 10
2012-08-24protein level
1 4 10
2012-08-24protein level
1 4 10
2012-07-28protein level
1 4 10
2012-07-28protein level
1 4 10
2012-07-28protein level
1 4 10
2012-06-08protein level
1 5 10
2012-06-08protein level
1 5 10
2012-06-08protein level
1 5 10
2012-05-07protein level
1 3 10
2012-05-07protein level
1 3 10
2012-05-07protein level
1 3 10
2012-04-10protein level
1 13 10
2012-04-10protein level
1 13 10
2012-04-10protein level
1 13 10
2012-01-13protein level
1 3 10
2012-01-13protein level
1 3 10
2012-01-13protein level
1 3 10
2011-12-20protein level
1 3 10
2011-12-20protein level
1 3 10
2011-12-20protein level
1 3 10
2011-11-11protein level
1 3 10
2011-11-11protein level
1 3 10
2011-11-11protein level
1 3 10
2011-08-23protein level
1 13 10
2011-08-23protein level
1 13 10
2011-08-23protein level
1 13 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P62158-1
8 0 1 16826.7886
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-397435,EBI-1566217 CCP110  
  .centrosome duplication
.regulation of cytokinesis
.cell projection organization
  + 4 more...
.N/A .protein complex
.cytosol
.centriole
.centrosome
2 EBI-397435,EBI-2909270 KCNH1  
  .potassium ion transmembrane transport
.regulation of membrane potential
.regulation of cell proliferation
  + 3 more...
.delayed rectifier potassium channel activity
.phosphorelay sensor kinase activity
.early endosome membrane
.voltage-gated potassium channel complex
.integral component of plasma membrane
  + 4 more...
3 EBI-397435,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
4 EBI-397435,EBI-494743 FAS  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 39 more...
.identical protein binding
.kinase binding
.transmembrane signaling receptor activity
  + 2 more...
.extracellular exosome
.membrane raft
.CD95 death-inducing signaling complex
  + 8 more...
5 EBI-397435,EBI-2902702 ADORA2A  
  .positive regulation of apoptotic signaling pathway
.prepulse inhibition
.regulation of inhibitory postsynaptic membrane potential
  + 49 more...
.identical protein binding
.enzyme binding
.G-protein coupled adenosine receptor activity
.presynaptic active zone
.postsynaptic membrane
.neuronal cell body
  + 10 more...
6 EBI-397435,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
7 EBI-397435,EBI-743313 ARRB1  
  .positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
8 EBI-397435,EBI-358616 DAPK1  
  .regulation of N-methyl-D-aspartate selective glutamate receptor activity
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.extrinsic apoptotic signaling pathway in absence of ligand
  + 13 more...
.identical protein binding
.syntaxin-1 binding
.GTP binding
  + 5 more...
.actin cytoskeleton
.plasma membrane
.cytoplasm
9 EBI-397435,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
10 EBI-397435,EBI-1038838 CACNA1C  
  .cell communication by electrical coupling involved in cardiac conduction
.membrane depolarization during action potential
.calcium ion import
  + 19 more...
.alpha-actinin binding
.metal ion binding
.high voltage-gated calcium channel activity
  + 2 more...
.dendritic shaft
.neuronal cell body
.Z disc
  + 6 more...
11 EBI-397435,EBI-726858 SCN5A  
  .regulation of sodium ion transmembrane transport
.regulation of heart rate by cardiac conduction
.AV node cell to bundle of His cell communication
  + 33 more...
.scaffold protein binding
.voltage-gated sodium channel activity involved in SA node cell action potential
.voltage-gated sodium channel activity involved in Purkinje myocyte action potential
  + 12 more...
.sarcolemma
.T-tubule
.lateral plasma membrane
  + 7 more...
12 EBI-397435,EBI-744790 C11orf65  
  .N/A .N/A .N/A
13 EBI-397435,EBI-681210 TTN  
  .cardiac muscle contraction
.cardiac muscle tissue morphogenesis
.cardiac myofibril assembly
  + 18 more...
.structural molecule activity conferring elasticity
.muscle alpha-actinin binding
.actin filament binding
  + 13 more...
.extracellular exosome
.I band
.M band
  + 5 more...
14 EBI-397435,EBI-947779 RCHY1  
  .error-free translesion synthesis
.protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 5 more...
.protein homodimerization activity
.ligase activity
.zinc ion binding
  + 2 more...
.nuclear speck
.cytoplasm
.nucleoplasm
  + 2 more...
15 EBI-397435,EBI-745878 KIAA1683  
  .N/A .N/A .mitochondrion
.nucleus
16 EBI-397435,EBI-307061 MYO10  
  .regulation of filopodium assembly
.innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
  + 4 more...
.plus-end directed microfilament motor activity
.actin filament binding
.actin-dependent ATPase activity
  + 3 more...
.filopodium tip
.filopodium membrane
.lamellipodium
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue466
adrenal gland1214
ascites1280
bladder7200
blood638
bone628
bone marrow1723
brain1295
cervix412
connective tissue355
ear1490
embryonic tissue624
esophagus99
eye229
heart201
intestine314
kidney507
larynx340
liver267
lung265
lymph248
lymph node122
mammary gland264
mouth15
muscle103
nerve579
ovary423
pancreas140
parathyroid242
pharynx24
pituitary gland726
placenta130
prostate290
salivary gland444
skin185
spleen168
stomach407
testis218
thymus188
thyroid300
tonsil352
trachea231
umbilical cord363
uterus271
vascular677
Health State
TissuesTPM*
normal622
adrenal tumor1896
bladder carcinoma11942
breast (mammary gland) tumor418
cervical tumor550
chondrosarcoma688
colorectal tumor364
esophageal tumor115
gastrointestinal tumor911
germ cell tumor809
glioma1352
head and neck tumor269
kidney tumor740
leukemia825
liver tumor1395
lung tumor447
lymphoma457
non-neoplasia300
ovarian tumor511
pancreatic tumor771
primitive neuroectodermal tumor of the CNS204
prostate cancer337
retinoblastoma882
skin tumor813
soft tissue/muscle tissue tumor566
uterine tumor865
Developmental Stage
TissuesTPM*
adult493
embryoid body871
blastocyst260
neonate611
fetus398
infant340
juvenile341
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue108.9
adrenal gland157.6
appendix224.6
bone marrow117.4
cerebral cortex587.6
colon341.4
duodenum410.1
esophagus103.3
gallbladder143
heart muscle252.6
kidney117.9
liver77
lung248.4
lymph node317.2
ovary138.7
pancreas88.9
placenta299.6
prostate181.7
salivary gland52.5
skin180.6
small intestine383.6
spleen200.6
stomach176.4
testis261.9
thyroid gland114.1
urinary bladder341.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeMedium
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusMedium
kidneyHigh
lateral ventricleHigh
liverHigh
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryHigh
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateHigh
rectumMedium
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
breast cancer
breast cancer
carcinoid
carcinoid
carcinoid
cervical cancer
cervical cancer
cervical cancer
colorectal cancer
colorectal cancer
colorectal cancer
endometrial cancer
endometrial cancer
endometrial cancer
glioma
glioma
glioma
head and neck cancer
head and neck cancer
head and neck cancer
liver cancer
liver cancer
liver cancer
lung cancer
lung cancer
lung cancer
lymphoma
lymphoma
lymphoma
melanoma
melanoma
melanoma
ovarian cancer
ovarian cancer
ovarian cancer
pancreatic cancer
pancreatic cancer
pancreatic cancer
prostate cancer
prostate cancer
prostate cancer
renal cancer
renal cancer
renal cancer
skin cancer
skin cancer
skin cancer
stomach cancer
stomach cancer
stomach cancer
testis cancer
testis cancer
testis cancer
thyroid cancer
thyroid cancer
thyroid cancer
urothelial cancer
urothelial cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*114180, gene) Calmodulin 1; CALM1OMIM
2(*114182, gene) Calmodulin 2; CALM2OMIM
3(*114183, gene) Calmodulin 3; CALM3OMIM
4(#614916, phenotype) Ventricular tachycardia, catecholaminergic polymorphic, 4; CPVT4OMIM

Protein
Gene SymbolCALM1 to neXtProt (NX_P62158)
DescriptionCalmodulin
Chromosome14
Location14q32.11 (90862846 ~ 90874605) to Ensembl
Sequene Features : Isoforms 1, Variants 8, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cell communication by electrical coupling involved in cardiac conduction
.regulation of high voltage-gated calcium channel activity
.positive regulation of protein serine/threonine kinase activity
  + 48 more...
.protein phosphatase activator activity
.ion channel binding
.protein serine/threonine kinase activator activity
  + 8 more...
.extracellular exosome
.vesicle
.growth cone
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 8 14
2015-01-01protein level
1 8 14
2015-01-01protein level
1 8 14
2014-09-19protein level
1 31 14
2014-09-19protein level
1 31 14
2014-09-19protein level
1 31 14
2014-05-27protein level
1 31 14
2014-05-27protein level
1 31 14
2014-05-27protein level
1 31 14
2014-02-25protein level
1 30 13
2014-02-25protein level
1 30 13
2014-02-25protein level
1 30 13
2013-12-09protein level
1 27 13
2013-12-09protein level
1 27 13
2013-12-09protein level
1 27 13
2013-11-01protein level
1 25 13
2013-11-01protein level
1 25 13
2013-11-01protein level
1 25 13
2013-09-12protein level
1 25 13
2013-09-12protein level
1 25 13
2013-09-12protein level
1 25 13
2013-08-17protein level
1 25 13
2013-08-17protein level
1 25 13
2013-08-17protein level
1 25 13
2013-07-15protein level
1 17 10
2013-07-15protein level
1 17 10
2013-07-15protein level
1 17 10
2013-06-11protein level
1 17 10
2013-06-11protein level
1 17 10
2013-06-11protein level
1 17 10
2013-02-12protein level
1 5 10
2013-02-12protein level
1 5 10
2013-02-12protein level
1 5 10
2012-12-20protein level
1 5 10
2012-12-20protein level
1 5 10
2012-12-20protein level
1 5 10
2012-10-30protein level
1 5 10
2012-10-30protein level
1 5 10
2012-10-30protein level
1 5 10
2012-10-07protein level
1 5 10
2012-10-07protein level
1 5 10
2012-10-07protein level
1 5 10
2012-08-24protein level
1 4 10
2012-08-24protein level
1 4 10
2012-08-24protein level
1 4 10
2012-07-28protein level
1 4 10
2012-07-28protein level
1 4 10
2012-07-28protein level
1 4 10
2012-06-08protein level
1 5 10
2012-06-08protein level
1 5 10
2012-06-08protein level
1 5 10
2012-05-07protein level
1 3 10
2012-05-07protein level
1 3 10
2012-05-07protein level
1 3 10
2012-04-10protein level
1 13 10
2012-04-10protein level
1 13 10
2012-04-10protein level
1 13 10
2012-01-13protein level
1 3 10
2012-01-13protein level
1 3 10
2012-01-13protein level
1 3 10
2011-12-20protein level
1 3 10
2011-12-20protein level
1 3 10
2011-12-20protein level
1 3 10
2011-11-11protein level
1 3 10
2011-11-11protein level
1 3 10
2011-11-11protein level
1 3 10
2011-08-23protein level
1 13 10
2011-08-23protein level
1 13 10
2011-08-23protein level
1 13 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P62158-1
8 0 1 16826.7886
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-397435,EBI-1566217 CCP110  
  .centrosome duplication
.regulation of cytokinesis
.cell projection organization
  + 4 more...
.N/A .protein complex
.cytosol
.centriole
.centrosome
2 EBI-397435,EBI-2909270 KCNH1  
  .potassium ion transmembrane transport
.regulation of membrane potential
.regulation of cell proliferation
  + 3 more...
.delayed rectifier potassium channel activity
.phosphorelay sensor kinase activity
.early endosome membrane
.voltage-gated potassium channel complex
.integral component of plasma membrane
  + 4 more...
3 EBI-397435,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
4 EBI-397435,EBI-494743 FAS  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 39 more...
.identical protein binding
.kinase binding
.transmembrane signaling receptor activity
  + 2 more...
.extracellular exosome
.membrane raft
.CD95 death-inducing signaling complex
  + 8 more...
5 EBI-397435,EBI-2902702 ADORA2A  
  .positive regulation of apoptotic signaling pathway
.prepulse inhibition
.regulation of inhibitory postsynaptic membrane potential
  + 49 more...
.identical protein binding
.enzyme binding
.G-protein coupled adenosine receptor activity
.presynaptic active zone
.postsynaptic membrane
.neuronal cell body
  + 10 more...
6 EBI-397435,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
7 EBI-397435,EBI-743313 ARRB1  
  .positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
8 EBI-397435,EBI-358616 DAPK1  
  .regulation of N-methyl-D-aspartate selective glutamate receptor activity
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.extrinsic apoptotic signaling pathway in absence of ligand
  + 13 more...
.identical protein binding
.syntaxin-1 binding
.GTP binding
  + 5 more...
.actin cytoskeleton
.plasma membrane
.cytoplasm
9 EBI-397435,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
10 EBI-397435,EBI-1038838 CACNA1C  
  .cell communication by electrical coupling involved in cardiac conduction
.membrane depolarization during action potential
.calcium ion import
  + 19 more...
.alpha-actinin binding
.metal ion binding
.high voltage-gated calcium channel activity
  + 2 more...
.dendritic shaft
.neuronal cell body
.Z disc
  + 6 more...
11 EBI-397435,EBI-726858 SCN5A  
  .regulation of sodium ion transmembrane transport
.regulation of heart rate by cardiac conduction
.AV node cell to bundle of His cell communication
  + 33 more...
.scaffold protein binding
.voltage-gated sodium channel activity involved in SA node cell action potential
.voltage-gated sodium channel activity involved in Purkinje myocyte action potential
  + 12 more...
.sarcolemma
.T-tubule
.lateral plasma membrane
  + 7 more...
12 EBI-397435,EBI-744790 C11orf65  
  .N/A .N/A .N/A
13 EBI-397435,EBI-681210 TTN  
  .cardiac muscle contraction
.cardiac muscle tissue morphogenesis
.cardiac myofibril assembly
  + 18 more...
.structural molecule activity conferring elasticity
.muscle alpha-actinin binding
.actin filament binding
  + 13 more...
.extracellular exosome
.I band
.M band
  + 5 more...
14 EBI-397435,EBI-947779 RCHY1  
  .error-free translesion synthesis
.protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 5 more...
.protein homodimerization activity
.ligase activity
.zinc ion binding
  + 2 more...
.nuclear speck
.cytoplasm
.nucleoplasm
  + 2 more...
15 EBI-397435,EBI-745878 KIAA1683  
  .N/A .N/A .mitochondrion
.nucleus
16 EBI-397435,EBI-307061 MYO10  
  .regulation of filopodium assembly
.innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
  + 4 more...
.plus-end directed microfilament motor activity
.actin filament binding
.actin-dependent ATPase activity
  + 3 more...
.filopodium tip
.filopodium membrane
.lamellipodium
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue466
adrenal gland1214
ascites1280
bladder7200
blood638
bone628
bone marrow1723
brain1295
cervix412
connective tissue355
ear1490
embryonic tissue624
esophagus99
eye229
heart201
intestine314
kidney507
larynx340
liver267
lung265
lymph248
lymph node122
mammary gland264
mouth15
muscle103
nerve579
ovary423
pancreas140
parathyroid242
pharynx24
pituitary gland726
placenta130
prostate290
salivary gland444
skin185
spleen168
stomach407
testis218
thymus188
thyroid300
tonsil352
trachea231
umbilical cord363
uterus271
vascular677
Health State
TissuesTPM*
normal622
adrenal tumor1896
bladder carcinoma11942
breast (mammary gland) tumor418
cervical tumor550
chondrosarcoma688
colorectal tumor364
esophageal tumor115
gastrointestinal tumor911
germ cell tumor809
glioma1352
head and neck tumor269
kidney tumor740
leukemia825
liver tumor1395
lung tumor447
lymphoma457
non-neoplasia300
ovarian tumor511
pancreatic tumor771
primitive neuroectodermal tumor of the CNS204
prostate cancer337
retinoblastoma882
skin tumor813
soft tissue/muscle tissue tumor566
uterine tumor865
Developmental Stage
TissuesTPM*
adult493
embryoid body871
blastocyst260
neonate611
fetus398
infant340
juvenile341
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue108.9
adrenal gland157.6
appendix224.6
bone marrow117.4
cerebral cortex587.6
colon341.4
duodenum410.1
esophagus103.3
gallbladder143
heart muscle252.6
kidney117.9
liver77
lung248.4
lymph node317.2
ovary138.7
pancreas88.9
placenta299.6
prostate181.7
salivary gland52.5
skin180.6
small intestine383.6
spleen200.6
stomach176.4
testis261.9
thyroid gland114.1
urinary bladder341.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeMedium
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusMedium
kidneyHigh
lateral ventricleHigh
liverHigh
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryHigh
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateHigh
rectumMedium
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
breast cancer
breast cancer
carcinoid
carcinoid
carcinoid
cervical cancer
cervical cancer
cervical cancer
colorectal cancer
colorectal cancer
colorectal cancer
endometrial cancer
endometrial cancer
endometrial cancer
glioma
glioma
glioma
head and neck cancer
head and neck cancer
head and neck cancer
liver cancer
liver cancer
liver cancer
lung cancer
lung cancer
lung cancer
lymphoma
lymphoma
lymphoma
melanoma
melanoma
melanoma
ovarian cancer
ovarian cancer
ovarian cancer
pancreatic cancer
pancreatic cancer
pancreatic cancer
prostate cancer
prostate cancer
prostate cancer
renal cancer
renal cancer
renal cancer
skin cancer
skin cancer
skin cancer
stomach cancer
stomach cancer
stomach cancer
testis cancer
testis cancer
testis cancer
thyroid cancer
thyroid cancer
thyroid cancer
urothelial cancer
urothelial cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*114180, gene) Calmodulin 1; CALM1OMIM
2(*114182, gene) Calmodulin 2; CALM2OMIM
3(*114183, gene) Calmodulin 3; CALM3OMIM
4(#614916, phenotype) Ventricular tachycardia, catecholaminergic polymorphic, 4; CPVT4OMIM

Protein
Gene SymbolCALM3 to neXtProt (NX_P62158)
DescriptionCalmodulin
Chromosome19
Location19q13.32 (47104331 ~ 47114050) to Ensembl
Sequene Features : Isoforms 1, Variants 8, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cell communication by electrical coupling involved in cardiac conduction
.regulation of high voltage-gated calcium channel activity
.positive regulation of protein serine/threonine kinase activity
  + 48 more...
.protein phosphatase activator activity
.ion channel binding
.protein serine/threonine kinase activator activity
  + 8 more...
.extracellular exosome
.vesicle
.growth cone
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 8 14
2015-01-01protein level
1 8 14
2015-01-01protein level
1 8 14
2014-09-19protein level
1 31 14
2014-09-19protein level
1 31 14
2014-09-19protein level
1 31 14
2014-05-27protein level
1 31 14
2014-05-27protein level
1 31 14
2014-05-27protein level
1 31 14
2014-02-25protein level
1 30 13
2014-02-25protein level
1 30 13
2014-02-25protein level
1 30 13
2013-12-09protein level
1 27 13
2013-12-09protein level
1 27 13
2013-12-09protein level
1 27 13
2013-11-01protein level
1 25 13
2013-11-01protein level
1 25 13
2013-11-01protein level
1 25 13
2013-09-12protein level
1 25 13
2013-09-12protein level
1 25 13
2013-09-12protein level
1 25 13
2013-08-17protein level
1 25 13
2013-08-17protein level
1 25 13
2013-08-17protein level
1 25 13
2013-07-15protein level
1 17 10
2013-07-15protein level
1 17 10
2013-07-15protein level
1 17 10
2013-06-11protein level
1 17 10
2013-06-11protein level
1 17 10
2013-06-11protein level
1 17 10
2013-02-12protein level
1 5 10
2013-02-12protein level
1 5 10
2013-02-12protein level
1 5 10
2012-12-20protein level
1 5 10
2012-12-20protein level
1 5 10
2012-12-20protein level
1 5 10
2012-10-30protein level
1 5 10
2012-10-30protein level
1 5 10
2012-10-30protein level
1 5 10
2012-10-07protein level
1 5 10
2012-10-07protein level
1 5 10
2012-10-07protein level
1 5 10
2012-08-24protein level
1 4 10
2012-08-24protein level
1 4 10
2012-08-24protein level
1 4 10
2012-07-28protein level
1 4 10
2012-07-28protein level
1 4 10
2012-07-28protein level
1 4 10
2012-06-08protein level
1 5 10
2012-06-08protein level
1 5 10
2012-06-08protein level
1 5 10
2012-05-07protein level
1 3 10
2012-05-07protein level
1 3 10
2012-05-07protein level
1 3 10
2012-04-10protein level
1 13 10
2012-04-10protein level
1 13 10
2012-04-10protein level
1 13 10
2012-01-13protein level
1 3 10
2012-01-13protein level
1 3 10
2012-01-13protein level
1 3 10
2011-12-20protein level
1 3 10
2011-12-20protein level
1 3 10
2011-12-20protein level
1 3 10
2011-11-11protein level
1 3 10
2011-11-11protein level
1 3 10
2011-11-11protein level
1 3 10
2011-08-23protein level
1 13 10
2011-08-23protein level
1 13 10
2011-08-23protein level
1 13 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P62158-1
8 0 1 16826.7886
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-397435,EBI-1566217 CCP110  
  .centrosome duplication
.regulation of cytokinesis
.cell projection organization
  + 4 more...
.N/A .protein complex
.cytosol
.centriole
.centrosome
2 EBI-397435,EBI-2909270 KCNH1  
  .potassium ion transmembrane transport
.regulation of membrane potential
.regulation of cell proliferation
  + 3 more...
.delayed rectifier potassium channel activity
.phosphorelay sensor kinase activity
.early endosome membrane
.voltage-gated potassium channel complex
.integral component of plasma membrane
  + 4 more...
3 EBI-397435,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
4 EBI-397435,EBI-494743 FAS  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 39 more...
.identical protein binding
.kinase binding
.transmembrane signaling receptor activity
  + 2 more...
.extracellular exosome
.membrane raft
.CD95 death-inducing signaling complex
  + 8 more...
5 EBI-397435,EBI-2902702 ADORA2A  
  .positive regulation of apoptotic signaling pathway
.prepulse inhibition
.regulation of inhibitory postsynaptic membrane potential
  + 49 more...
.identical protein binding
.enzyme binding
.G-protein coupled adenosine receptor activity
.presynaptic active zone
.postsynaptic membrane
.neuronal cell body
  + 10 more...
6 EBI-397435,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
7 EBI-397435,EBI-743313 ARRB1  
  .positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
8 EBI-397435,EBI-358616 DAPK1  
  .regulation of N-methyl-D-aspartate selective glutamate receptor activity
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.extrinsic apoptotic signaling pathway in absence of ligand
  + 13 more...
.identical protein binding
.syntaxin-1 binding
.GTP binding
  + 5 more...
.actin cytoskeleton
.plasma membrane
.cytoplasm
9 EBI-397435,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
10 EBI-397435,EBI-1038838 CACNA1C  
  .cell communication by electrical coupling involved in cardiac conduction
.membrane depolarization during action potential
.calcium ion import
  + 19 more...
.alpha-actinin binding
.metal ion binding
.high voltage-gated calcium channel activity
  + 2 more...
.dendritic shaft
.neuronal cell body
.Z disc
  + 6 more...
11 EBI-397435,EBI-726858 SCN5A  
  .regulation of sodium ion transmembrane transport
.regulation of heart rate by cardiac conduction
.AV node cell to bundle of His cell communication
  + 33 more...
.scaffold protein binding
.voltage-gated sodium channel activity involved in SA node cell action potential
.voltage-gated sodium channel activity involved in Purkinje myocyte action potential
  + 12 more...
.sarcolemma
.T-tubule
.lateral plasma membrane
  + 7 more...
12 EBI-397435,EBI-744790 C11orf65  
  .N/A .N/A .N/A
13 EBI-397435,EBI-681210 TTN  
  .cardiac muscle contraction
.cardiac muscle tissue morphogenesis
.cardiac myofibril assembly
  + 18 more...
.structural molecule activity conferring elasticity
.muscle alpha-actinin binding
.actin filament binding
  + 13 more...
.extracellular exosome
.I band
.M band
  + 5 more...
14 EBI-397435,EBI-947779 RCHY1  
  .error-free translesion synthesis
.protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 5 more...
.protein homodimerization activity
.ligase activity
.zinc ion binding
  + 2 more...
.nuclear speck
.cytoplasm
.nucleoplasm
  + 2 more...
15 EBI-397435,EBI-745878 KIAA1683  
  .N/A .N/A .mitochondrion
.nucleus
16 EBI-397435,EBI-307061 MYO10  
  .regulation of filopodium assembly
.innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
  + 4 more...
.plus-end directed microfilament motor activity
.actin filament binding
.actin-dependent ATPase activity
  + 3 more...
.filopodium tip
.filopodium membrane
.lamellipodium
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue466
adrenal gland1214
ascites1280
bladder7200
blood638
bone628
bone marrow1723
brain1295
cervix412
connective tissue355
ear1490
embryonic tissue624
esophagus99
eye229
heart201
intestine314
kidney507
larynx340
liver267
lung265
lymph248
lymph node122
mammary gland264
mouth15
muscle103
nerve579
ovary423
pancreas140
parathyroid242
pharynx24
pituitary gland726
placenta130
prostate290
salivary gland444
skin185
spleen168
stomach407
testis218
thymus188
thyroid300
tonsil352
trachea231
umbilical cord363
uterus271
vascular677
Health State
TissuesTPM*
normal622
adrenal tumor1896
bladder carcinoma11942
breast (mammary gland) tumor418
cervical tumor550
chondrosarcoma688
colorectal tumor364
esophageal tumor115
gastrointestinal tumor911
germ cell tumor809
glioma1352
head and neck tumor269
kidney tumor740
leukemia825
liver tumor1395
lung tumor447
lymphoma457
non-neoplasia300
ovarian tumor511
pancreatic tumor771
primitive neuroectodermal tumor of the CNS204
prostate cancer337
retinoblastoma882
skin tumor813
soft tissue/muscle tissue tumor566
uterine tumor865
Developmental Stage
TissuesTPM*
adult493
embryoid body871
blastocyst260
neonate611
fetus398
infant340
juvenile341
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue108.9
adrenal gland157.6
appendix224.6
bone marrow117.4
cerebral cortex587.6
colon341.4
duodenum410.1
esophagus103.3
gallbladder143
heart muscle252.6
kidney117.9
liver77
lung248.4
lymph node317.2
ovary138.7
pancreas88.9
placenta299.6
prostate181.7
salivary gland52.5
skin180.6
small intestine383.6
spleen200.6
stomach176.4
testis261.9
thyroid gland114.1
urinary bladder341.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeMedium
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusMedium
kidneyHigh
lateral ventricleHigh
liverHigh
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryHigh
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateHigh
rectumMedium
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
breast cancer
breast cancer
carcinoid
carcinoid
carcinoid
cervical cancer
cervical cancer
cervical cancer
colorectal cancer
colorectal cancer
colorectal cancer
endometrial cancer
endometrial cancer
endometrial cancer
glioma
glioma
glioma
head and neck cancer
head and neck cancer
head and neck cancer
liver cancer
liver cancer
liver cancer
lung cancer
lung cancer
lung cancer
lymphoma
lymphoma
lymphoma
melanoma
melanoma
melanoma
ovarian cancer
ovarian cancer
ovarian cancer
pancreatic cancer
pancreatic cancer
pancreatic cancer
prostate cancer
prostate cancer
prostate cancer
renal cancer
renal cancer
renal cancer
skin cancer
skin cancer
skin cancer
stomach cancer
stomach cancer
stomach cancer
testis cancer
testis cancer
testis cancer
thyroid cancer
thyroid cancer
thyroid cancer
urothelial cancer
urothelial cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*114180, gene) Calmodulin 1; CALM1OMIM
2(*114182, gene) Calmodulin 2; CALM2OMIM
3(*114183, gene) Calmodulin 3; CALM3OMIM
4(#614916, phenotype) Ventricular tachycardia, catecholaminergic polymorphic, 4; CPVT4OMIM


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