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> Protein (NX_P62191)
Protein (NX_P62191)
Protein
Gene SymbolPSMC1 to neXtProt (NX_P62191)
Description26S protease regulatory subunit 4
Chromosome14
Location14q32.11 (90722839 ~ 90738968) to Ensembl
Sequene Features : Isoforms 2, Variants 28, PTMs 18 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of proteasomal protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.poly(A) RNA binding
.proteasome-activating ATPase activity
.TBP-class protein binding
  + 2 more...
.cytosolic proteasome complex
.nuclear proteasome complex
.cell junction
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 28 18
2014-09-19protein level
2 19 18
2014-05-27protein level
1 19 18
2014-02-25protein level
1 19 18
2013-12-09protein level
1 18 18
2013-11-01protein level
1 17 17
2013-09-12protein level
1 17 17
2013-08-17protein level
1 17 17
2013-07-15protein level
1 6 8
2013-06-11protein level
1 6 8
2013-02-12protein level
1 1 5
2012-12-20protein level
1 2 5
2012-10-30protein level
1 3 5
2012-10-07protein level
1 3 5
2012-08-24protein level
1 3 5
2012-07-28protein level
1 3 5
2012-06-08protein level
1 5 5
2012-05-07protein level
1 4 5
2012-04-10protein level
1 4 5
2012-01-13protein level
1 7 5
2011-12-20protein level
1 7 5
2011-11-11protein level
1 7 5
2011-08-23protein level
1 7 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P62191-1
4 19 0 49153.5516
NX_P62191-2
0 19 0 41141.0831
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-357598,EBI-349968 SUV39H1  
  .cellular response to hypoxia
.rhythmic process
.negative regulation of transcription, DNA-templated
  + 15 more...
.protein N-terminus binding
.histone methyltransferase activity (H3-K9 specific)
.histone methyltransferase activity
  + 5 more...
.rDNA heterochromatin
.chromatin silencing complex
.nucleoplasm
  + 5 more...
2 EBI-357598,EBI-710124 KDM1A  
  .positive regulation of stem cell proliferation
.positive regulation of neural precursor cell proliferation
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  + 27 more...
.androgen receptor binding
.flavin adenine dinucleotide binding
.transcription regulatory region DNA binding
  + 13 more...
.transcription factor complex
.nucleoplasm
.nucleus
.nuclear chromatin
3 EBI-357598,EBI-359710 PSMC2  
  .positive regulation of proteasomal protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 26 more...
.proteasome-activating ATPase activity
.TBP-class protein binding
.ATPase activity
.ATP binding
.cytosolic proteasome complex
.nuclear proteasome complex
.proteasome accessory complex
  + 8 more...
4 EBI-357598,EBI-357669 PSMC6  
  .positive regulation of proteasomal protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.proteasome-activating ATPase activity
.protein binding, bridging
.TBP-class protein binding
  + 2 more...
.extracellular exosome
.cytosolic proteasome complex
.nuclear proteasome complex
  + 7 more...
5 EBI-357598,EBI-357648 PSMD2  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 21 more...
.enzyme regulator activity .extracellular exosome
.proteasome accessory complex
.membrane
  + 4 more...
6 EBI-357598,EBI-752143 PSMD5  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.proteasome regulatory particle assembly
  + 22 more...
.N/A .proteasome accessory complex
.cytosol
.nucleoplasm
.proteasome complex
7 EBI-357598,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites200
bladder167
blood89
bone69
bone marrow82
brain70
cervix41
connective tissue13
ear186
embryonic tissue98
esophagus99
eye71
heart78
intestine68
kidney56
liver82
lung146
lymph112
lymph node77
mammary gland152
mouth166
muscle141
ovary187
pancreas56
parathyroid145
pharynx171
pituitary gland121
placenta173
prostate110
salivary gland98
skin147
spleen56
stomach83
testis98
thymus62
thyroid85
tonsil58
umbilical cord145
uterus51
Health State
TissuesTPM*
normal64
adrenal tumor237
bladder carcinoma113
breast (mammary gland) tumor171
cervical tumor57
chondrosarcoma12
colorectal tumor79
esophageal tumor115
gastrointestinal tumor151
germ cell tumor102
glioma74
head and neck tumor112
kidney tumor116
leukemia63
liver tumor114
lung tumor379
lymphoma124
non-neoplasia10
ovarian tumor223
pancreatic tumor114
primitive neuroectodermal tumor of the CNS236
prostate cancer134
retinoblastoma172
skin tumor223
soft tissue/muscle tissue tumor47
uterine tumor77
Developmental Stage
TissuesTPM*
adult83
embryoid body42
blastocyst81
neonate64
fetus66
infant127
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.5
adrenal gland10.9
appendix13.9
bone marrow14.8
cerebral cortex9.8
colon11.8
duodenum8.2
esophagus8
gallbladder7.1
heart muscle11.6
kidney12.3
liver7.2
lung11.7
lymph node9.5
ovary8.6
pancreas4.8
placenta11.4
prostate12.1
salivary gland6.4
skin10.5
small intestine8.8
spleen9.5
stomach8.8
testis15.5
thyroid gland7.3
urinary bladder6.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602706, gene) Proteasome 26s subunit, atpase, 1; PSMC1OMIM


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