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> Protein (NX_P62258)
Protein (NX_P62258)
Protein
Gene SymbolYWHAE to neXtProt (NX_P62258)
Description14-3-3 protein epsilon
Chromosome17
Location17p13.3 (1247566 ~ 1303672) to Ensembl
Sequene Features : Isoforms 2, Variants 25, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of peptidyl-serine dephosphorylation
.regulation of potassium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 27 more...
.phosphoprotein binding
.phosphoserine binding
.protein heterodimerization activity
  + 7 more...
.extracellular exosome
.melanosome
.cytoplasmic vesicle membrane
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 25 16
2014-09-19protein level
2 16 16
2014-05-27protein level
2 16 20
2014-02-25protein level
2 16 20
2013-12-09protein level
2 14 21
2013-11-01protein level
2 13 18
2013-09-12protein level
2 13 18
2013-08-17protein level
2 13 18
2013-07-15protein level
2 10 14
2013-06-11protein level
2 10 14
2013-02-12protein level
2 2 22
2012-12-20protein level
2 2 22
2012-10-30protein level
2 2 22
2012-10-07protein level
2 2 12
2012-08-24protein level
2 0 12
2012-07-28protein level
2 0 12
2012-06-08protein level
2 3 12
2012-05-07protein level
2 7 12
2012-04-10protein level
2 7 12
2012-01-13protein level
2 6 12
2011-12-20protein level
2 6 12
2011-11-11protein level
2 6 11
2011-08-23protein level
2 6 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P62258-1
2 12 2 29155.3343
NX_P62258-2
0 12 2 26487.134
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-356498,EBI-4392727 CBX4  
  .negative regulation of transcription, DNA-templated
.cellular protein metabolic process
.post-translational protein modification
  + 5 more...
.transcription regulatory region DNA binding
.SUMO binding
.enzyme binding
  + 5 more...
.PRC1 complex
.PcG protein complex
.nuclear speck
  + 2 more...
2 EBI-356498,EBI-446492 APAF1  
  .positive regulation of apoptotic signaling pathway
.regulation of apoptotic DNA fragmentation
.intrinsic apoptotic signaling pathway
  + 11 more...
.ADP binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
.ATP binding
.nucleotide binding
.extracellular exosome
.apoptosome
.cytosol
.nucleus
3 EBI-356498,EBI-398437 MDM4  
  .cellular response to hypoxia
.negative regulation of cell cycle arrest
.protein stabilization
  + 9 more...
.enzyme binding
.zinc ion binding
.nucleoplasm
.nucleus
4 EBI-356498,EBI-1043945 CDK14  
  .regulation of canonical Wnt signaling pathway
.regulation of cell cycle
.cell division
  + 2 more...
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.plasma membrane
.cytosol
.cytoplasm
  + 2 more...
5 EBI-356498,EBI-365996 RAF1  
  .regulation of cell motility
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.death-inducing signaling complex assembly
  + 36 more...
.metal ion binding
.identical protein binding
.ATP binding
  + 3 more...
.pseudopodium
.plasma membrane
.cytosol
  + 4 more...
6 EBI-356498,EBI-365961 ARAF  
  .negative regulation of apoptotic process
.positive regulation of peptidyl-serine phosphorylation
.regulation of proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.metal ion binding
.ATP binding
.receptor signaling protein activity
  + 2 more...
.N/A
7 EBI-356498,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
8 EBI-356498,EBI-308629 HDAC4  
  .histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.actomyosin
.A band
.neuromuscular junction
  + 7 more...
9 EBI-356498,EBI-721328 MLF1  
  .cell cycle arrest
.transcription, DNA-templated
.myeloid progenitor cell differentiation
.protein domain specific binding
.DNA binding
.cytoplasm
.nucleoplasm
.nucleus
10 EBI-356498,EBI-359832 YWHAG  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 14 more...
.poly(A) RNA binding
.protein kinase C inhibitor activity
.insulin-like growth factor receptor binding
.protein kinase C binding
.extracellular exosome
.cytoplasmic vesicle membrane
.membrane
  + 2 more...
11 EBI-356498,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
12 EBI-356498,EBI-6173812 KANK1  
  .negative regulation of lamellipodium morphogenesis
.regulation of establishment of cell polarity
.negative regulation of ruffle assembly
  + 11 more...
.beta-catenin binding .ruffle membrane
.cytoplasm
.nucleus
13 EBI-356498,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
14 EBI-356498,EBI-2652799 STAC  
  .intracellular signal transduction
.cellular response to heat
.signal transduction
.metal ion binding .cytosol
15 EBI-356498,EBI-307281 MAP3K3  
  .positive regulation of p38MAPK cascade
.protein autophosphorylation
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 5 more...
.metal ion binding
.ATP binding
.MAP kinase kinase kinase activity
  + 2 more...
.cytosol
.intracellular
16 EBI-356498,EBI-747743 WWTR1  
  .negative regulation of canonical Wnt signaling pathway
.regulation of metanephric nephron tubule epithelial cell differentiation
.kidney morphogenesis
  + 23 more...
.transcription corepressor activity
.transcription coactivator activity
.cytosol
.cytoplasm
.transcription factor complex
  + 2 more...
17 EBI-356498,EBI-960409 FBXO4  
  .positive regulation of protein ubiquitination
.SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
.protein ubiquitination
  + 3 more...
.protein homodimerization activity
.ubiquitin-protein transferase activity
.SCF ubiquitin ligase complex
.cytoplasm
.ubiquitin ligase complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland425
ascites803
bladder401
blood327
bone530
bone marrow328
brain607
cervix639
connective tissue214
ear186
embryonic tissue474
esophagus992
eye416
heart927
intestine396
kidney417
larynx85
liver555
lung400
lymph158
lymph node178
mammary gland423
mouth468
muscle376
nerve514
ovary433
pancreas224
parathyroid582
pharynx122
pituitary gland121
placenta289
prostate232
salivary gland246
skin317
spleen112
stomach512
testis542
thymus100
thyroid364
trachea96
umbilical cord363
uterus551
vascular1181
Health State
TissuesTPM*
normal400
adrenal tumor316
bladder carcinoma56
breast (mammary gland) tumor483
cervical tumor637
chondrosarcoma555
colorectal tumor355
esophageal tumor1043
gastrointestinal tumor666
germ cell tumor444
glioma307
head and neck tumor343
kidney tumor333
leukemia328
liver tumor666
lung tumor350
lymphoma360
non-neoplasia745
ovarian tumor459
pancreatic tumor323
primitive neuroectodermal tumor of the CNS795
prostate cancer298
retinoblastoma925
skin tumor239
soft tissue/muscle tissue tumor486
uterine tumor366
Developmental Stage
TissuesTPM*
adult342
embryoid body485
blastocyst537
neonate257
fetus382
infant2211
juvenile899
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue285.4
adrenal gland287.1
appendix204
bone marrow127.2
cerebral cortex535.8
colon284.4
duodenum195.3
esophagus204
gallbladder146.3
heart muscle261.1
kidney341
liver210.9
lung212.4
lymph node148.3
ovary214.6
pancreas127.3
placenta282.9
prostate245.7
salivary gland200.3
skin154.5
small intestine215.1
spleen162.1
stomach243.7
testis257.3
thyroid gland267.1
urinary bladder193.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605066, gene) Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,OMIM
2edometrial stromal sarcoma;Miller-Dieker lissencephaly syndromeCGP


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