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> Protein (NX_P62310)
Protein (NX_P62310)
Protein
Gene SymbolLSM3 to neXtProt (NX_P62310)
DescriptionU6 snRNA-associated Sm-like protein LSm3
Chromosome3
Location3p25.1 (14219858 ~ 14242619) to Ensembl
Sequene Features : Isoforms 1, Variants 8, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.mRNA processing
  + 2 more...
.poly(A) RNA binding .catalytic step 2 spliceosome
.cytosol
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 8 1
2014-09-19protein level
1 6 1
2014-05-27protein level
1 6 1
2014-02-25protein level
1 5 1
2013-12-09protein level
1 5 1
2013-11-01protein level
1 4 1
2013-09-12protein level
1 4 1
2013-08-17protein level
1 4 1
2013-07-15protein level
1 1 0
2013-06-11protein level
1 1 0
2013-02-12protein level
1 0 1
2012-12-20protein level
1 0 1
2012-10-30protein level
1 0 1
2012-10-07protein level
1 0 1
2012-08-24protein level
1 0 1
2012-07-28protein level
1 0 1
2012-06-08protein level
1 1 1
2012-05-07protein level
1 2 1
2012-04-10protein level
1 2 1
2012-01-13protein level
1 0 1
2011-12-20protein level
1 0 1
2011-11-11protein level
1 0 1
2011-08-23protein level
1 0 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P62310-1
4 0 0 11837.9895
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-348239,EBI-347619 LSM1  
  .histone mRNA catabolic process
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
  + 5 more...
.poly(A) RNA binding
.RNA cap binding
.cytosol
.cytoplasm
.nucleus
.cytoplasmic mRNA processing body
2 EBI-348239,EBI-347779 LSM8  
  .mRNA splicing, via spliceosome .poly(A) RNA binding
.U6 snRNA 3'-end binding
.U6 snRNA binding
.U4/U6 x U5 tri-snRNP complex
.spliceosomal complex
3 EBI-348239,EBI-724693 CLNS1A  
  .ncRNA metabolic process
.gene expression
.cell volume homeostasis
  + 2 more...
.protein heterodimerization activity
.poly(A) RNA binding
.pICln-Sm protein complex
.methylosome
.plasma membrane
  + 5 more...
4 EBI-348239,EBI-749995 TCL1A  
  .stem cell maintenance
.multicellular organismal development
.N/A .pronucleus
.cell cortex
.endoplasmic reticulum
5 EBI-348239,EBI-373310 LSM6  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.maturation of SSU-rRNA
.gene expression
  + 4 more...
.poly(A) RNA binding .extracellular exosome
.U4/U6 x U5 tri-snRNP complex
.small nuclear ribonucleoprotein complex
  + 6 more...
6 EBI-348239,EBI-354065 YBX1  
  .CRD-mediated mRNA stabilization
.positive regulation of cell division
.negative regulation of striated muscle cell differentiation
  + 8 more...
.GTPase binding
.poly(A) RNA binding
.RNA binding
  + 6 more...
.histone pre-mRNA 3'end processing complex
.CRD-mediated mRNA stability complex
.extracellular exosome
  + 8 more...
7 EBI-348239,EBI-751001 KEAP1  
  .cellular response to interleukin-4
.regulation of epidermal cell differentiation
.negative regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.transcription factor binding .Cul3-RING ubiquitin ligase complex
.midbody
.cytosol
  + 4 more...
8 EBI-348239,EBI-373268 LSM10  
  .positive regulation of G1/S transition of mitotic cell cycle
.mRNA 3'-end processing
.gene expression
  + 4 more...
.histone pre-mRNA DCP binding .Cajal body
.U7 snRNP
.nucleoplasm
.nucleus
9 EBI-348239,EBI-348372 LSM7  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.mRNA splicing, via spliceosome
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.U6 snRNA binding .cytosol
.small nucleolar ribonucleoprotein complex
.spliceosomal complex
10 EBI-348239,EBI-347416 LSM2  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.RNA splicing
  + 2 more...
.poly(A) RNA binding
.Ral GTPase binding
.U6 snRNA binding
.catalytic step 2 spliceosome
.cytosol
.nucleoplasm
11 EBI-348239,EBI-373007 LSM5  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.RNA splicing
  + 2 more...
.RNA binding .cytosol
.spliceosomal complex
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites50
bladder100
blood65
bone27
bone marrow123
brain25
cervix20
connective tissue87
ear310
embryonic tissue32
esophagus49
eye62
heart134
intestine73
kidney61
liver68
lung32
lymph22
lymph node33
mammary gland59
mouth105
muscle28
nerve64
ovary68
pancreas74
parathyroid242
pharynx49
pituitary gland121
placenta21
prostate84
salivary gland98
skin33
stomach94
testis62
thyroid21
umbilical cord217
uterus51
vascular19
Health State
TissuesTPM*
normal49
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor53
cervical tumor28
chondrosarcoma60
colorectal tumor44
esophageal tumor57
gastrointestinal tumor67
germ cell tumor34
glioma65
head and neck tumor44
kidney tumor58
leukemia31
liver tumor114
lung tumor19
lymphoma41
non-neoplasia41
ovarian tumor78
pancreatic tumor95
primitive neuroectodermal tumor of the CNS23
prostate cancer96
retinoblastoma64
skin tumor15
soft tissue/muscle tissue tumor103
uterine tumor77
Developmental Stage
TissuesTPM*
adult59
embryoid body42
neonate96
fetus44
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.4
adrenal gland9
appendix9.1
bone marrow9.1
cerebral cortex8
colon11
duodenum8.5
esophagus8
gallbladder6.2
heart muscle11.3
kidney17.3
liver8.7
lung7
lymph node10.1
ovary7.6
pancreas3.7
placenta8.8
prostate9.5
salivary gland5.8
skin7.2
small intestine9.5
spleen7.3
stomach8.9
testis10.1
thyroid gland9.3
urinary bladder9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607283, gene) Lsm3 protein; LSM3OMIM


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