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> Protein (NX_P62312)
Protein (NX_P62312)
Protein
Gene SymbolLSM6 to neXtProt (NX_P62312)
DescriptionU6 snRNA-associated Sm-like protein LSm6
Chromosome4
Location4q31.22 (147096837 ~ 147121152) to Ensembl
Sequene Features : Isoforms 1, Variants 7, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.maturation of SSU-rRNA
.gene expression
  + 4 more...
.poly(A) RNA binding .extracellular exosome
.U4/U6 x U5 tri-snRNP complex
.small nuclear ribonucleoprotein complex
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 7 3
2014-09-19protein level
1 6 3
2014-05-27protein level
1 6 3
2014-02-25protein level
1 6 3
2013-12-09protein level
1 3 3
2013-11-01protein level
1 3 1
2013-09-12protein level
1 3 1
2013-08-17protein level
1 3 1
2013-07-15protein level
1 1 1
2013-06-11protein level
1 1 1
2013-02-12protein level
1 0 1
2012-12-20protein level
1 0 1
2012-10-30protein level
1 0 1
2012-10-07protein level
1 0 1
2012-08-24protein level
1 0 1
2012-07-28protein level
1 0 1
2012-06-08protein level
1 0 1
2012-05-07protein level
1 1 1
2012-04-10protein level
1 1 1
2012-01-13protein level
1 0 1
2011-12-20protein level
1 0 1
2011-11-11protein level
1 0 1
2011-08-23protein level
1 0 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P62312-1
5 0 0 9121.7406
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-373310,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-373310,EBI-724693 CLNS1A  
  .ncRNA metabolic process
.gene expression
.cell volume homeostasis
  + 2 more...
.protein heterodimerization activity
.poly(A) RNA binding
.pICln-Sm protein complex
.methylosome
.plasma membrane
  + 5 more...
3 EBI-373310,EBI-348239 LSM3  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.mRNA processing
  + 2 more...
.poly(A) RNA binding .catalytic step 2 spliceosome
.cytosol
.nucleus
4 EBI-373310,EBI-348372 LSM7  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.mRNA splicing, via spliceosome
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.U6 snRNA binding .cytosol
.small nucleolar ribonucleoprotein complex
.spliceosomal complex
5 EBI-373310,EBI-373007 LSM5  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.RNA splicing
  + 2 more...
.RNA binding .cytosol
.spliceosomal complex
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone27
brain9
connective tissue67
embryonic tissue32
eye14
heart67
intestine8
kidney23
lung29
lymph node89
mammary gland6
ovary19
pancreas23
pharynx73
placenta3
prostate31
skin4
spleen18
stomach10
testis13
tonsil352
uterus21
vascular38
Health State
TissuesTPM*
normal24
colorectal tumor8
germ cell tumor11
glioma46
head and neck tumor7
kidney tumor29
leukemia10
ovarian tumor13
pancreatic tumor9
prostate cancer9
soft tissue/muscle tissue tumor103
Developmental Stage
TissuesTPM*
adult18
embryoid body42
blastocyst16
fetus17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue36.3
adrenal gland24.8
appendix40.9
bone marrow23.6
cerebral cortex16.5
colon30.8
duodenum24.9
esophagus16.8
gallbladder18.8
heart muscle10.7
kidney25.9
liver22.3
lung26.4
lymph node50.3
ovary22.8
pancreas6.5
placenta25.9
prostate26.4
salivary gland15.6
skin13.6
small intestine27.3
spleen35.6
stomach28.1
testis24.1
thyroid gland11.3
urinary bladder22.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607286, gene) Lsm6 protein; LSM6OMIM


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