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> Protein (NX_P62807)
Protein (NX_P62807)
Protein
Gene SymbolHIST1H2BC to neXtProt (NX_P62807)
DescriptionHistone H2B type 1-C/E/F/G/I
Chromosome6
Location6p22.2 (26115101 ~ 26124154) to Ensembl
Sequene Features : Isoforms 1, Variants 27, PTMs 31 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.defense response to Gram-positive bacterium
.antibacterial humoral response
.nucleosome assembly
  + 2 more...
.DNA binding .extracellular exosome
.nucleoplasm
.nucleus
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 27 31
2014-09-19protein level
1 86 31
2014-05-27protein level
1 86 42
2014-02-25protein level
1 84 42
2013-12-09protein level
1 68 42
2013-11-01protein level
1 66 40
2013-09-12protein level
1 66 36
2013-08-17protein level
1 66 37
2013-07-15protein level
1 45 41
2013-06-11protein level
1 45 41
2013-02-12protein level
1 19 31
2012-12-20protein level
1 19 31
2012-10-30protein level
1 22 23
2012-10-07protein level
1 22 23
2012-08-24protein level
1 17 23
2012-07-28protein level
1 16 23
2012-06-08protein level
1 18 23
2012-05-07protein level
1 15 23
2012-04-10protein level
1 10 23
2012-01-13protein level
1 8 22
2011-12-20protein level
1 8 22
2011-11-11protein level
1 8 20
2011-08-23protein level
1 6 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P62807-1
0 0 5 13897.5159
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-354552,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
blood16
bone13
bone marrow41
brain2
connective tissue13
ear124
embryonic tissue4
esophagus99
eye33
heart11
intestine8
kidney14
liver4
lung2
lymph node11
mammary gland13
mouth15
nerve64
ovary137
pancreas4
placenta10
prostate10
salivary gland49
skin9
spleen18
testis2
Health State
TissuesTPM*
normal2
bladder carcinoma56
breast (mammary gland) tumor21
chondrosarcoma24
esophageal tumor115
germ cell tumor7
head and neck tumor14
leukemia21
liver tumor10
ovarian tumor183
pancreatic tumor9
prostate cancer9
uterine tumor22
Developmental Stage
TissuesTPM*
adult2
blastocyst16
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1.1
appendix1.4
bone marrow11.9
colon2.5
duodenum1.9
esophagus4.4
gallbladder3.3
heart muscle1.2
kidney1.1
lymph node2.9
placenta2.4
prostate1.2
salivary gland1.3
skin1.6
small intestine2.3
spleen2.3
stomach3.2
urinary bladder4.4
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602798, gene) Histone gene cluster 1, h2b histone family, member g; HIST1H2BGOMIM
2(*602804, gene) Histone gene cluster 1, h2b histone family, member f; HIST1H2BFOMIM
3(*602805, gene) Histone gene cluster 1, h2b histone family, member e; HIST1H2BEOMIM
4(*602807, gene) Histone gene cluster 1, h2b histone family, member i; HIST1H2BIOMIM
5(*602847, gene) Histone gene cluster 1, h2b histone family, member c; HIST1H2BCOMIM


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